Method for preparing W/O/W type compound emulsion embedding chlorogenic acid, product and application of W/O/W type compound emulsion

A technology of chlorogenic acid and colostrum, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, applications, etc., can solve the problems of chlorogenic acid inactivation and sensitization, and achieve effective release , to promote the effect of sustained release

Active Publication Date: 2010-01-06
HUABAO FLAVOURS & FRAGRANCES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chlorogenic acid is easily inactivated by proteins in the body and has sensitizing effects on humans
After the human body inhales the dust containing chlorogenic acid, it may cause asthma, but after ingestion, it can be transformed into a non-allergenic substance through the secretion of the small intestine

Method used

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  • Method for preparing W/O/W type compound emulsion embedding chlorogenic acid, product and application of W/O/W type compound emulsion
  • Method for preparing W/O/W type compound emulsion embedding chlorogenic acid, product and application of W/O/W type compound emulsion
  • Method for preparing W/O/W type compound emulsion embedding chlorogenic acid, product and application of W/O/W type compound emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take 9 grams of liquid paraffin as the oil phase, 1 gram of Span80 as the lipophilic emulsifier, and 9 grams of chlorogenic acid aqueous solution with a concentration of 75% as the inner water phase, mix the inner water phase, the lipophilic emulsifier and the oil phase, and mix them at high speed Stir at 8000 r / min for 6 min on a dispersing homogenizer to prepare colostrum. In this way, the mass concentration of the emulsifier in the oil phase is 10%, the mass ratio of the inner water phase to the oil phase is 1:1, and the content of the chlorogenic acid aqueous solution in the colostrum is 35.5%.

[0043]Dilute the colostrum 10 times in liquid paraffin, take the sample on Angel AQ-2010C high-power phase contrast microscope, observe its structure and particle size with an oil lens and take its micrograph, take a small amount of sample and place it on a clean glass slide , cover with a cover glass, put it under a microscope, adjust the microscope to observe the microstr...

Embodiment 2

[0045] Colostrum was prepared in the same ratio as in Example 1, except that the components were mixed and then stirred at 9500 r / min for 6 minutes on a high-speed dispersing homogenizer.

[0046] Dilute the colostrum 10 times in liquid paraffin, take the sample on Angel AQ-2010C high-power phase contrast microscope, observe its structure and particle size with an oil lens and take its micrograph, take a small amount of sample and place it on a clean glass slide , cover with a cover glass, put it under a microscope, adjust the microscope to observe the microstructure of the sample, and take micrographs of the sample with the camera that comes with the microscope.

[0047] Example 2

[0048] Colostrum was prepared in the same ratio as in Example 1, except that the components were mixed and then stirred at 9500 r / min for 6 minutes on a high-speed dispersing homogenizer.

[0049] Dilute the colostrum 10 times in liquid paraffin, take the sample on Angel AQ-2010C high-power phase...

Embodiment 3

[0051] Colostrum was prepared in the same ratio as in Example 1, except that the components were mixed and then stirred at 13500 r / min for 6 minutes on a high-speed dispersing homogenizer.

[0052] Dilute the colostrum 10 times in liquid paraffin, take the sample on Angel AQ-2010C high-power phase contrast microscope, observe its structure and particle size with an oil lens and take its micrograph, take a small amount of sample and place it on a clean glass slide , cover with a cover glass, put it under a microscope, adjust the microscope to observe the microstructure of the sample, and take micrographs of the sample with the camera that comes with the microscope.

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Abstract

The invention relates to a method for preparing W/O/W type compound emulsion embedding an chlorogenic acid, belonging to the field of compound emulsion preparation and comprising the following steps: mixing 1 part of aqueous chlorogenic acid solution by weight, 2 parts of oil phases by weight and 0.2-0.4 part of lipophilic emulsifier by weight to be stirred for 4-10 minutes under the speed of 6,000-15,000 turns/minute so as to obtain W/O type colostrums; and then mixing 2-3 parts of the W/O type colostrums and 2-3 parts of external water phrases to be stirred for 2-10 minutes under the speed of 1000-6000 turns/minute so as to obtain the W/O/W type compound emulsion. The method for preparing the W/O/W type compound emulsion can not only play roles of protection and storage on the chlorogenic acid, but also realize the uniform and effective release of the chlorogenic acid in human bodies, and also promotes the slow release, the controlled release and the target effect of absorption and sufficiently plays a role of the chlorogenic acid by embedding the hlorogenic acid with the W/O/W type compound emulsion.

Description

【Technical field】 [0001] The invention relates to spices and a preparation method thereof, in particular to a preparation method of W / O / W double emulsion embedding chlorogenic acid, a product obtained by the method, and its use as a spice additive in cigarettes. 【Background technique】 [0002] Chlorogenic acid is a depsipated acid composed of caffeic acid and quinic acid (1-hydroxyhexahydrogallic acid). A phenylpropanoid compound produced by the body through the shikimate pathway during aerobic respiration. Chlorogenic acid is widely found in higher dicotyledonous plants and ferns, mainly in Lonicera genus of Lonicera family and Artemisia genus of Asteraceae family, among which the plants with higher content are mainly Eucommia, honeysuckle, sunflower, eucommia, coffee, etc. . [0003] Chlorogenic acid has many functions such as scavenging free radicals, antibacterial and anti-inflammatory, antiviral, hypoglycemic, lipid-lowering, liver-protecting and gallbladder-protectin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/113A61K31/216A61K47/36A61P35/00A61P31/18A61P39/06A61P29/00A61P31/04A61P31/12A61P3/10A61P3/06A61P1/16C11B9/00A24B15/30
Inventor 谷向春罗昌荣
Owner HUABAO FLAVOURS & FRAGRANCES CO LTD
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