Embedding system based on eutectic solvent and using eutectic solvent as solvent

A low eutectic solvent and system technology, which is applied in the field of embedding systems based on a deep eutectic solvent as a solvent, can solve problems such as side effects, and achieve the effects of reduced toxicity, easy preparation and efficient dissolution

Active Publication Date: 2018-06-22
ANHUI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to improve the druggability of paclitaxel, the solvent system of castor oil and ethanol is used as the above drug solvent system, but it inevitably brings a series of side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Preparation of DES: Firstly, by vacuum evaporation, benzyltriethylammonium chloride and urea components are dissolved in water at a molar ratio of 4:1, evaporated with a rotary evaporator at 50°C, and the obtained liquid is dried on silica gel In the container until the constant weight; then using the heating method, the above product is stirred under heating conditions (about 80°C) until a clear and uniform mixed solution is formed, and the mixed solution is heated at 45°C with P 2 o 5 Drying for at least two weeks yields DES.

[0022] Preparation of drug carrier: soybean phosphatidylcholine (SPC), cholesterol and cultured phosphatidylethanolamine (mPEG 2000 -DEPE) was dispersed in water according to the molar ratio of 60:30:7, and then freeze-dried to obtain liposomes.

[0023] Embedding: dissolving the drug doxorubicin (DOX), which is an effective drug for treating tumors, in DES, and loading the drug dissolved in DES on the liposome.

[0024] After co-incubating ...

Embodiment 2

[0026] Preparation of DES: Firstly, using vacuum evaporation method, choline chloride and urea components were dissolved in water at a molar ratio of 1:1, evaporated with a rotary evaporator at 50 ° C, and the obtained liquid was placed in a silica gel desiccator until Constant weight; then using the heating method, the above product is stirred under heating conditions (about 80°C) until a clear and uniform mixed solution is formed, and the mixed solution is heated at 45°C with P 2 o 5 Drying for at least two weeks yields DES.

[0027] Preparation of drug carrier: soybean phosphatidylcholine (SPC), cholesterol and cultured phosphatidylethanolamine (mPEG 2000 -DEPE) was dispersed in water according to the molar ratio of 60:30:7, and then freeze-dried to obtain liposomes.

[0028] Embedding: dissolving the drug doxorubicin (DOX), which is an effective drug for treating tumors, in DES, and loading the drug dissolved in DES on the liposome.

[0029] After co-incubating the drug...

Embodiment 3

[0031] Preparation of DES: Firstly, ethylene glycol, propylene glycol, butylene glycol, sorbitol, and benzyltriethylammonium chloride were dissolved in water at a molar ratio of 1:1:1:1:20 by vacuum evaporation method, at 50 Evaporate with a rotary evaporator at ℃, place the obtained liquid in a silica gel desiccator until constant weight; then use heating method, stir the above product under heating conditions (about 80 ℃) until a clear and uniform mixed solution is formed, The mixture was heated at 45°C with P 2 o 5 Drying for at least two weeks yields DES.

[0032] Preparation of drug carrier: soybean phosphatidylcholine (SPC), cholesterol and cultured phosphatidylethanolamine (mPEG 2000 -DEPE) was dispersed in water according to the molar ratio of 60:30:7, and then freeze-dried to obtain liposomes.

[0033] Embedding: dissolving oxaliplatin, an effective drug for treating tumors, in DES, and loading the drug dissolved in DES on liposomes.

[0034] After co-incubating t...

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Abstract

The invention provides an embedding system based on a eutectic solvent and using the eutectic solvent as a solvent. The embedding system comprises an embedding material, a carrier and the eutectic solvent, and the eutectic solvent is formed by a hydrogen bond donor and a hydrogen bond acceptor through hydrogen bond association; the hydrogen bond acceptor includes quaternary ammonium salt, and thehydrogen bond donor includes one or more of urea, polyol, monosaccharide and carboxylic acid. The embedding system uses the eutectic solvent to serve as the solvent, and the eutectic solvent can increase the embedding rate of medicine, is low in toxicity and degradable, can reduce the side effects of the medicine in a controlled release and medicine delivery process and can improve the permeability and controllable release performance of cell membranes.

Description

technical field [0001] The invention relates to the technical field of biochemical industry, in particular to an embedding system based on a deep eutectic solvent as a solvent. Background technique [0002] Tumor is one of the diseases that seriously threaten human health. According to the latest statistics, there are as many as 14 million cancer cases worldwide each year, with a death rate of 8.2 million, and more than 25 million cancer cases worldwide. In the past 20 years, the incidence and mortality of cancer in my country have been on the rise. According to statistics, in 2011, there were about 3.372 million new cancer cases in my country, and about 2.213 million people died of cancer. There are 6.4 people diagnosed with cancer every minute in the whole country, about 9216 people become cancer patients every day, and on average, one person dies of cancer in every 7-8 people. The current severe situation has prompted medical experts to break through the traditional mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K47/18A61K47/10A61K47/26A61K47/12A61K31/704A61K31/555
CPCA61K9/1271A61K31/555A61K31/704A61K47/10A61K47/12A61K47/18A61K47/186A61K47/26
Inventor 徐霞张二伟颜庭轩张楷徐建
Owner ANHUI UNIVERSITY OF TECHNOLOGY
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