Preparation method of graphene oxide/poly(N-isopropylacrylamide) composite hydrogel

A technology of isopropylacrylamide and composite hydrogel, which is applied in the field of materials and achieves the effects of wide application prospects, good temperature responsiveness and mechanical properties

Inactive Publication Date: 2012-07-18
QINGDAO UNIV
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  • Abstract
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However, so far, there are few reports on gr

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  • Preparation method of graphene oxide/poly(N-isopropylacrylamide) composite hydrogel

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Embodiment 1

[0020] Add the mixture of 360mL sulfuric acid and 40mL phosphoric acid into the mixture of 3.0g flake graphite and 18.0g potassium permanganate, raise the temperature to 50°C, stir for 12h, then cool the reactant to room temperature, pour into the mixture containing 3mL30% H 2 o 2 400mL of ice water, centrifugal separation, centrifugal speed 4000rpm, remove supernatant, solid matter was washed with 200mL water respectively, centrifugal separation, 200mL 30% NCl washing, centrifugal separation, 200mL ethanol washing, centrifugal separation, finally the solid matter obtained Graphite oxide can be obtained by freeze-drying.

[0021] Add 0.0067g of graphite oxide and 12mL of water into a 15mL reaction tube respectively, put them into an ultrasonic oscillator for ultrasonic dispersion for 30 minutes; then add 0.6750g of N-isopropylacrylamide and 0.0270g of N,N'-methylene base bisacrylamide, 0.0067g sodium sulfite, stirring and dissolving; fill the reaction tube with nitrogen to re...

Embodiment 2

[0023] Repeat embodiment 1, difference is: the add-on of graphite oxide is 0.0335g.

Embodiment 3

[0025] Repeat Example 1, the difference is: the addition of graphite oxide is 0.0670g, ultrasonic dispersion 45min.

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Abstract

The invention discloses a preparation method of graphene oxide/poly(N-isopropylacrylamide) composite hydrogel. The preparation method comprises the steps of: firstly, placing the graphene oxide in water and ultrasonically dispersing the graphene oxide for 30-60 min to obtain a graphene oxide colloidal solution; then adding N-isopropylacrylamide, a cross-linking agent and an initiator 1 in the graphene oxide colloidal solution; stirring for dissolving so as to obtain a mixed solution; then inflating nitrogen in the mixed solution to deoxidize fully, then adding an initiator 2 in the deoxidized mixed solution, mixing uniformly and placing the mixture in a thermostatic water bath at 25+/-1 DEG C so as to obtain the graphene oxide/poly(N-isopropylacrylamide) composite hydrogel. The graphene oxide/poly(N-isopropylacrylamide) composite hydrogel prepared by the method disclosed by the invention has the advantages of good temperature responsiveness and mechanical property and wide application prospect in the biomedical field (such as tissue engineering and drug controlled release).

Description

technical field [0001] The invention relates to a preparation method of graphene oxide / poly(N-isopropylacrylamide) composite hydrogel, which belongs to the field of material technology. Background technique [0002] Smart hydrogels are a class of hydrogels that can respond sensitively to external stimuli (such as temperature, pH value, solvent, salt concentration, light, electricity, etc.). Due to its unique stimuli responsiveness, it has an important position and unique use in many fields, especially in biomedical fields (such as biosensing, molecular separation, immobilization of active enzymes, tissue engineering, artificial muscles, drug carriers, etc.), and is widely accepted. s concern. Among them, the temperature-sensitive poly(N-isopropylacrylamide) (PNIPAM) hydrogel has attracted the most attention because its volume phase transition temperature is near the normal physiological temperature of the human body. However, the traditional large-size PNIPAM hydrogels (ma...

Claims

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Application Information

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IPC IPC(8): B01J13/00
Inventor 马晓梅李艳红王文超纪全夏延致
Owner QINGDAO UNIV
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