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Preparation method of chitosan microcapsule with uniform size and controllable size

A chitosan microcapsule and uniform technology, applied in the field of microfluidics, can solve the problems of troublesome post-processing and complicated preparation process, and achieve the effect of simple device, good monodispersity and regular shape

Inactive Publication Date: 2014-04-16
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above method is still slightly complicated in the preparation process, and the post-processing is troublesome.

Method used

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  • Preparation method of chitosan microcapsule with uniform size and controllable size
  • Preparation method of chitosan microcapsule with uniform size and controllable size

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Self-made microfluidic device

[0036]First, insert a circular capillary 3 with a length of 4 cm (inner diameter 600 μm, outer diameter 1000 μm, one end drawn into a tapered end 5 with an outlet diameter of 200-300 μm) into a square capillary 4 (inner diameter 1000 μm) of about 3 cm, circular The tapered end 5 of the capillary 3 extends about 1mm from one end of the square capillary 4, the undrawn tapered end of the circular capillary 3 extends out of the square capillary 4 and is connected to a PTFE tube (not shown), and the other end of the square capillary 4 is connected to Put the PVC pipe (not shown in the figure); finally, all the connections are glued and sealed by epoxy resin, and after curing for 24 hours, the microfluidic device (such as figure 1 )can use.

[0037] (2) Preparation of chitosan microcapsules

[0038] Add 2g of chitosan to 10mL of 0.2mol / L acetic acid solution, stir for 2 hours at room temperature with a magnet to fully dissolve the chitosa...

Embodiment 2

[0040] Use the self-made microfluidic device in step (1) of Example 1. The chitosan solution in step (2) of Example 1 is controlled by a micro-injection pump, injected into the vertically fixed microfluidic device at 3mL / h, and the gas is also controlled by a rotameter to pass into the microfluidic device at 45L / h. Fluidic device, under the action of gas shear, the internal phase solution forms micro-droplets at the outlet of the microfluidic device, and drops into the 4wt% sodium dodecyl sulfate receiver solution placed directly below the microfluidic device ; Through the neutralization of positive and negative charges, microcapsules are gradually formed, and then after about half an hour of aging, the microcapsules are taken out, washed and stored in water, and finally monodisperse chitosan microcapsules are obtained. The average particle size is 541 μm, and the CV value is 5.83%.

Embodiment 3

[0042] The self-made microfluidic device in step (1) of Example 1 was used. The chitosan solution in step (2) of Example 1 is controlled by a micro-injection pump, and injected into the vertically fixed microfluidic device at 3mL / h; at the same time, the gas is also controlled by a rotameter and passed into the microfluidic device at 60L / h. Fluidic device, under the action of gas shear, the internal phase solution forms micro-droplets at the outlet of the microfluidic device, and drops into the 4wt% sodium dodecyl sulfate receiver solution placed directly below the microfluidic device ; Through the neutralization of positive and negative charges, microcapsules are gradually formed, and then after about half an hour of aging, the microcapsules are taken out, washed and stored in water, and finally monodisperse chitosan microcapsules are obtained. The average particle size is 311 μm, and the CV value is 5.03%.

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Abstract

The invention relates to a preparation method of chitosan microcapsule with uniform size and controllable size using a microfluidic device based on gas-liquid shearing principle. The preparation method specifically comprises the steps: firstly assembling the microfluidic device, then introducing a chitosan or chitosan quaternary ammonium salt solution as an internal phase, and a gas as an external phase into the microfluidic device, under the strong shearing action of the gas, forming micro-droplets by the internal phase solution at an outlet of the microfluidic device, dripping the micro-droplets into receptor fluid of an anionic surfactant or polyanion electrolyte, and precipitating and condensing chitosan or chitosan quaternary ammonium salt to form a layer of polymer film shell on outer layers of the micro-droplets, thus finally obtaining the chitosan microcapsule. The chitosan microcapsule prepared by the preparation method is regular in shape and uniform in size distribution, the size of the microcapsule can be effectively controlled by changing flow velocity conditions, and the preparation process is convenient and easy, and strong in operability. The obtained microcapsule can be used in the fields of active material microencapsulation and drug controlled release.

Description

technical field [0001] The invention relates to the field of microfluidic technology, in particular to a method for preparing chitosan microcapsules with uniform size and controllable size. Background technique [0002] Chitosan can be obtained from chitin through deacetylation reaction. It is the only polycationic basic polysaccharide existing in nature. It has good non-toxicity, biological activity, biocompatibility, in vivo degradability and film-forming properties. The chitosan microcapsules formed by it have been widely used in the controlled release of drugs, cosmetics industry, food industry and so on. The traditional preparation methods of chitosan microcapsules include emulsification-crosslinking method, emulsification-solvent evaporation method, single coacervation method, complex coacervation method, spray drying method, etc. Most of these methods have microcapsule size inhomogeneity, uncontrollability, and preparation The disadvantages of low efficiency and poor...

Claims

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Application Information

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IPC IPC(8): B01J13/10
Inventor 陈艳军姚荣沂王艺峰陈明周佑亮丁妮
Owner WUHAN UNIV OF TECH
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