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Multifunctional multilayered micro/nano core-shell structure

A core-shell structure and nano-core-shell technology, which is applied in the direction of microcapsules, nanocapsules, oil/fat/wax non-effective ingredients, etc., can solve the problems of limiting the types of materials used, difficult to control particle shape, and easy particle agglomeration. To achieve the effect of enriching application directions, facilitating adjustment, and easy control of the operation process

Inactive Publication Date: 2015-04-08
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing mainstream preparation methods including sol-gel method, template method, deposition method, microfluidic method, etc. for the preparation of three-layer core-shell particles basically meet the preparation requirements in terms of the manipulation of the two components. When it has a complex structure, it is limited by a series of problems, such as cumbersome process, low yield, need for additives or auxiliary tools, difficult to control particle shape, easy particle agglomeration, etc.
In comparison, the self-assembly method is flexible for the control of multi-component structures, but the formation mechanism based on electrostatic interactions also limits the types of materials used

Method used

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Examples

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preparation example Construction

[0042] The preparation method involved in the multilayer micro / nano core-shell structure of the present invention, such as flow process figure 2 As shown (three layers are shown), proceed as follows:

[0043] (1) Prepare a polymer solution, dissolve the polymer in an organic solvent, and stir to obtain a uniform transparent solution;

[0044] (2) Prepare electrospray liquid, add dye and other auxiliary materials in the above-mentioned polymer solution, stir to make electrospray liquid;

[0045] (3) The electrospray liquid is moved into the syringe, driven by the micro-injection pump, the electrospray liquid is electrosprayed through the three-way coaxial needle, and the electrospray method is carried out.

[0046] Devices used such as figure 1 As shown in , the basic composition includes: a liquid storage pool 1, a high-voltage electrostatic generator 6, a micro-injection pump 2, a three-way coaxial needle 3, an annular ground electrode 4, and a collection device 5. The si...

Embodiment 1

[0051] Experimental device according to figure 1 As shown in the construction, the experimental results are as follows Figure 3A shown. Experimental materials Polyε-caprolactone (average molecular weight 45,000) and dye rhodamine B were purchased from Aldrich Co. (USA). Prepare a solution with a mass fraction of PCL of 5%, use dichloromethane as a solvent, and stir on a magnetic stirrer at a speed of 200 r / min for 20 minutes to obtain a colorless and transparent solution, and add 0.05 mg of the dye Rhodamine B to it , after stirring evenly, it was used as the inner layer solution of electrospray; olive oil was not treated as the middle layer solution of electrospray; a solution with a mass fraction of polyε-caprolactone of 5% was prepared, and dichloromethane was used as a solvent in a magnetic stirrer Stir at a speed of 200 r / min for 20 minutes to obtain a colorless transparent solution, which is used as the outer layer solution of electrospray after being stirred evenly. ...

Embodiment 2

[0054] Prepare a solution with a mass fraction of polyε-caprolactone of 5%, using dichloromethane as a solvent, and stirring at a speed of 200 r / min on a magnetic stirrer for 20 minutes to obtain a colorless and transparent solution, and polyε-caprolactone according to the mass ratio - Caprolactone solution: Fe 3 o 4 : Tween 80 = 96:3:1 Stir several materials evenly, this solution is used as the outermost layer solution of EFI; mineral oil is not treated as the middle layer solution of EFI; the mass fraction of polyε-caprolactone is prepared to be 5 % solution of 10 ml, using dichloromethane as a solvent, and adding 0.05 g of paclitaxel drug in it, after stirring evenly, this solution was used as the innermost solution of electrospray.

[0055] Transfer the prepared electrospray solution into a syringe (5 ml), connect it to the outer, middle and inner channels of the ternary coaxial needle through silicone tubes, adjust the speed of the syringe pump, and adjust the flow rates...

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Abstract

The invention discloses a multifunctional multilayered micro / nano core-shell structure. The core-shell structure is a micro / nanoscale spherical structure, and the ''multilayer'' includes three or more layers. At least one layer of material is a liquid phase. The liquid phase can selectively be removed. Thickness of each shell is controllable, and each shell can effectively and independently coat multiple materials or anti-cancer drugs with different properties at the same time. By adding functional auxiliary materials into each phase, combination of multifunctional characteristics can be realized. By integrating advantages of the multilayered core-shell structure and excellent optical, electrical, magnetic, sound and biological characteristics, drug controlled release and medical imaging application can be realized. The multifunctional multilayered micro / nano core-shell structure has an application prospect especially in aspects of disease treatment and medical imaging and is used as a bimodal ultrasonic / magnetic imaging diagnosis contrast agent and drug release control carrier.

Description

technical field [0001] The invention belongs to the field of preparation of micro / nano materials, and in particular relates to a multifunctional multilayer core-shell structure micro / nano particle as a multifunctional medical imaging and drug carrier. Background technique [0002] Micro / nanoparticles have high specific surface area, quantum size effect and surface effect which are different from macroscopic materials. With the development of technology, materials with single functions can no longer meet the demand, so the research focus has gradually shifted from simple particle preparation to multifunctional micro-nano particles with special structures and composite types. Micro-nano particles with core-shell structure have multiple superior properties due to the double particularity of size and structure, and have broad application prospects in the fields of sensing, catalysis, photonic crystals, coatings, cosmetics, food, and biomedicine. Especially in the field of biome...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/44A61K49/00A61K41/00A61P35/00
Inventor 张明暐高园李劲松
Owner ZHEJIANG UNIV
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