37 results about "3-methylbutyric acid" patented technology

The flavor and aroma characteristics of the smoke of a tobacco blend incorporating Oriental tobacco are improved by subjecting that blend to heat treatment. Oriental tobacco having a relatively high sucrose ester content is combined with a second dissimilar Oriental tobacco material and/or a non-Oriental tobacco material to form a tobacco mixture, and that mixture is heated for a time and under conditions sufficient to reduce the concentration of sucrose esters in the Oriental tobacco. Tobacco blends having reduced levels of sucrose esters yield smoke that does not possess undesirable off-notes provided by pyrolysis products of those sucrose esters; namely, 2-methylpropionic acid, 3-methylbutyric acid and 3-methylpentanoic acid.

A method for manufacturing 3-hydroxy-3-methylbutanoic acid (HMB) in commercially viable amounts is disclosed. The reaction mixture cycles through an external heat exchanger while the primary reactant is added in a warmer so as to control and maintain a low temperature for the reaction mixture. The manufacturing process herein disclosed increases yield while decreasing reaction time from the synthetic processes currently practiced.

The invention relates to an antisludging agent for preventing the deposition of Sr/Ba scale and the antisludging agent is used to prevent the deposition of Sr/Ba scale of an oil well during oil field production process. The antisludging agent comprises the following components by weight percent: 8.5-12% of dodecylaminoethyl phosphate, 7.5-9.0% of myristylaminoethyl phosphate, 5-6.5% of EDTA disodium salt, 2.5-3.0% of EDTP tetrasodium salt, 3.5-4.5% of ethylenediamine tetra methylenephosphonic acid, 0.05-0.08% of vitamin A, 0.05-0.12% of vitamin C, 0.005-0.01% of potassium iodide, 0.0005-0.001% of alpha-amino-3-methylbutyric acid, 0.0005-0.0010% of aspartic acid and the balance water, wherein the sum of the weight percentages of the components is 100%. The beneficial effect of the antisludging agent is as follows: when 25-30mg/l of the antisludging agent of the invention is used in the daily maintenance of the oil well, the scale preventing rate is more than 90% and the pump detection period of the oil well can be increased by more than once.

The invention discloses a solvent-free waterborne polyurethane resin and a preparation method thereof. The solvent-free waterborne polyurethane resin comprises the following raw materials in parts byweight: 80-150 parts of polyester or polyether glycol, 1-25 parts of 2,2-dihydroxymethyl isovaleric acid (2,2-dihydroxymethyl-3-methyl butyrate), 0-10 parts of hydrophilic carboxyl dihydric alcohol, 0-15 parts of micromolecule dihydric alcohol, 0-10 parts of nonionic dihydric alcohol, 40-150 parts of diisocyanate, 1-20 parts of a salting agent, 0-30 parts of a diamine chain extender and 500-700 parts of deionized water. The resin is free of organic solvent in the preparation process, low in prepolymer viscosity and high in dispersion stability.

The invention discloses amidase, a coding gene and applications thereof. The amino acid sequence of the amidase is represented by the SEQ ID No.2. The amidase gene is cloned from acid-producing Klebsiella oxytoca KCTC 1686 genome. After the expression of the amidase gene, amidase can be successfully obtained, and the amidase has the advantages of high catalytic activity, good stereo-selectivity, high expression amount, and wind substrate spectrum. The obtained amidase can be used to prepare optically-pure chiral compounds especially an important medicine intermediate 2-(4-chlorophenyl)-3-methylbutyric acid. The recombinant amidase can be used to catalyze a racemic substrate 2-(4-chlorophenyl)-3-methylbutyramide, and when the substrate conversion rate is near 50%, the optical purity of the (S)-2-(4-chlorophenyl)-3-methylbutyric acid is 98.5%.

The invention discloses an acylation reaction method for preparing 2-4-(chlorophenyl)-3-methylbutyryl chloride. The acylation reaction method comprises the following steps: adding 900-950 parts by weight of 2-4-(chlorophenyl)-3-methylbutyric acid, 10-12 parts by weight of acetic acid and 20-25 parts by weight of activated carbon into a reaction kettle, dripping 510-520 parts by weight of thionyl chloride into the reaction kettle at normal temperature, performing heat release reaction, increasing the temperature to 80 DEG C, then opening the reaction kettle, stirring, performing heat preservation for 6hours after the end of dripping of the thionyl chloride, and press-filtering out the activated carbon and other impurities to obtain a crude product 2-4-(chlorophenyl)-3-methylbutyryl chloride. According to the acylation reaction method, the activated carbon is adopted for heat absorption, so that the smooth reaction conditions can be ensured, the yield is greatly improved, the acetic acid is increased and the stable reaction conditions are ensured so as to be conductive to performing the reaction.

The invention discloses a synthesis process of compound D-2- aminoxy-3-methylbutyric acid, and belongs to the technical field of chemical synthesis. The synthesis process includes taking natural amino acid L-valine as a raw material, and then synthetizing the non-natural D-2- aminoxy-3-methylbutyric acid by steps of diazotization hydrolysis, acetyl protection, tert-butyl esterification, deacetylation, Mitsunobu reaction, dephthaloyl, tert-butyl ester hydrolysis and the like. The compound is synthetized by raw materials easy to obtain and is low-price; synthesis operations are convenient and simple, reaction conditions are mild and easy to control, reaction selectivity is good, yield is high, and accordingly the compound is suitable for industrial production.

Disclosed is a novel flavor-improving agent. Specifically disclosed is a flavor-improving agent which contains 3-methylbutanoic acid as an active ingredient.

A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with anti-fungal small molecules in an amount effective to reduce or inhibit conidial germination and mycelial growth. A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with anti-fungal small molecules in an amount effective to reduce or inhibit conidial germination and mycelial growth. The anti-fungal small molecules are 5-(p-Bromobenzylidine)-α-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid, 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, [5-(4-isopropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid or 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid. The species of the fungal cell is selected from a group that has an obligate symbiosis with the mountain pine beetle (Dendroctonus ponderosae) and the western pine beetle (Dendroctonus brevicomis).

The present invention is related to a pork-flavor enhancer for food and soups, and contains 3-methylbutyric acid as an active ingredient.

An oil modifier is prepared from 20-50% of 3-methylbutyric acid, 20-30% of streptomyces fradiae, 5-15% of fatty acid, 10-15% of amino acid and the balance inevitable impurities. The oil modifier has the advantage of being good in use effect.

The invention discloses one aspect, a high temperature resistant coating, comprising the following components in parts by weight: 20-30 parts of methyl 2-hydroxy-3-methyl butyrate, 12-16 parts of polyvinyl alcohol, polyamideimide 8-12 parts of amine, 6-8 parts of polyetherimide, 4-8 parts of polyimide, 7-15 parts of dibutyl ester, 6-12 parts of pentaerythritol, 12-24 parts of norfloxacin, dihydroacetate 6-12 parts of pine oil ester, 6-12 parts of dihydroterpineol, 4-12 parts of ethylene glycol monohexyl ether, 6-10 parts of dimethylethanolamine, 14-18 parts of cobalt calcium carbonate. The invention provides a kind of high temperature resistant coating, various components cooperate with each other, the coating has low toxicity, and the coating effect is good, and the service time is long. , can play the role of anti-corrosion and high temperature resistance.

The invention relates to a preparation method of MOC (methoxycarbonyl group)-L-tertiary leucine, in particular to a method for preparing the MOC-L-tertiary leucine by separating 2-methoxyamide-3, 3-methylbutanoic acid. The method comprises the following steps of forming two kinds of diastereoisomer amine salts by using the 2-methoxyamide-3, 3-methylbutanoic acid and a resolving agent which is an amine compound; separating the two kinds of diastereoisomer amine salts to obtain MOC-L- tertiary leucine amine salt; and performing acid dissociation on the MOC-L- tertiary leucine amine salt to obtain the MOC-L-tertiary leucine. The method is low in cost, a technology is simple and reasonable, the purity of products is high, and the method is suitable for industrial production of the MOC-L-tertiary leucine.

The invention discloses a preparation method of 3,3-dimethyl butanol. According to the preparation method, in ethanol, 3,3-methylbutanoic acid is subjected to esterification under acid catalysis; and one-pot reaction is adopted in the presence of a hydroboron so as to obtain end product 3,3-dimethyl butanol. Using of flammable and combustible reagents (such as lithium aluminium hydride) and solvents (such as ether) is avoided; the end product is obtained via one-pot reaction; yield is high; purity is high; the raw materials are cheap, and source is wide; end product cost is low; and the preparation method is suitable for industrialized production.

The invention discloses green and non-toxic paint. The green and non-toxic paint comprises, by weight, 20 parts of 2-hydroxyl-3-methylbutyric acid methyl ester, 12 parts of polyvinyl alcohol, 12 partsof difluoro tetrachloroethane, 5 parts of chloroprene adhesive, 4 parts of sodium hydroxide, 12 parts of methyl celluloses, 12 parts of antimony trioxide, 4 parts of vanadium trioxide, 10 parts of azodicarbonamide, 12 parts of benzoyl peroxide, 8 parts of isopropyl alcohol, 4 parts of isopropyl acrylate and 8 parts of butyl acetate. The green and non-toxic paint has the advantages that various components in the green and non-toxic paint are matched with one another, and the green and non-toxic paint is low in toxicity; good paint smearing effects can be realized, and the green and non-toxic paint is long in service time.

The invention discloses a synthetic process for a compound, i.e., D-2-aminoxy-3-methylbutyric acid. The synthetic process synthesizes non-natural D-2-aminoxy-3-methylbutyric acid with natural amino acid L-valine as a starting raw material through diazotization hydrolysis, acetyl protection, t-butyl esterification, deacetylation, Mitsunobu reaction, removal of a phthalyl group, hydrolysis of tert-butyl ester, etc. The synthetic process has the following advantages: raw materials are easily available and cheap; synthesis operation is simple; reaction conditions are mild and easy to control; reaction selectivity is good; yield is high; and the process is suitable for industrial production.