Process for manufacturing 3-hydroxy-3-methylbutanoic acid

a technology of 3-hydroxymethylbutanoic acid and manufacturing process, which is applied in the field of manufacturing process of 3-hydroxy-3-methylbutanoic acid, can solve the problems of significant and unexpected improvement in the addition rate of reactants, rise in the temperature of the reaction mixture, and reduce the yield and amount of the desired product hmb. , the effect of increasing the yield and quality of the produ
US20010014757A1Inactive Publication Date: 2001-08-16MET RX USA
0 Cites 6 Cited by

Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
MET RX USA
Publication Date
2001-08-16
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

A method for manufacturing 3-hydroxy-3-methylbutanoic acid (HMB) in commercially viable amounts is disclosed. The reaction mixture cycles through an external heat exchanger while the primary reactant is added in a warmer so as to control and maintain a low temperature for the reaction mixture. The manufacturing process herein disclosed increases yield while decreasing reaction time from the synthetic processes currently practiced.
Need to check novelty before this filing date? Find Prior Art

Description

[0001] This is a continuation of U.S. patent application Ser. No. 09 / 539,351, filed Mar. 31, 2000, which is a continuation of U.S. patent application Ser. No. 08 / 685,599, filed Jul. 19, 1996, now U.S. Pat. No. 6,090,978, all of which are incorporated herein by reference.

[0002] This invention relates to methods for manufacturing 3-hydroxy-3-methylbutanoic acid (HMB) in high yield, in large batch amounts, with high quality, and in a relatively short amount of time.BACKGROUND OF INVENTION

[0003] Several reports have recently appeared disclosing that HMB exhibits significant efficacy for nitrogen retention and muscle building in humans. See Nissen et al., U.S. Pat. No. 5,348,979; Phillips, Muscle Media 2000 (October 1995), "HMB New Drug-Free Mass Builder;" these and all other references cited herein are expressly incorporated by reference as if fully set forth in their entirety herein. Promoting nitrogen retention has therapeutic importance for trauma patients and for patients showing lo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More