50 results about "3-Methylbutanoic acid" patented technology

The flavor and aroma characteristics of the smoke of a tobacco blend incorporating Oriental tobacco are improved by subjecting that blend to heat treatment. Oriental tobacco having a relatively high sucrose ester content is combined with a second dissimilar Oriental tobacco material and/or a non-Oriental tobacco material to form a tobacco mixture, and that mixture is heated for a time and under conditions sufficient to reduce the concentration of sucrose esters in the Oriental tobacco. Tobacco blends having reduced levels of sucrose esters yield smoke that does not possess undesirable off-notes provided by pyrolysis products of those sucrose esters; namely, 2-methylpropionic acid, 3-methylbutyric acid and 3-methylpentanoic acid.

A method for manufacturing 3-hydroxy-3-methylbutanoic acid (HMB) in commercially viable amounts is disclosed. The reaction mixture cycles through an external heat exchanger while the primary reactant is added in a warmer so as to control and maintain a low temperature for the reaction mixture. The manufacturing process herein disclosed increases yield while decreasing reaction time from the synthetic processes currently practiced.

Provided herein are processes for the preparation of (S)-(2R,3R,11bR-3-isobuty-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), or a solvate, hydrate, or polymorph thereof.

The invention provides a heat-resistant and salt-tolerant polymer oil-displacing agent and a preparation method thereof. The heat-resistant and salt-tolerant polymer oil-displacing agent has the structure shown in the formula (I) (in the description); both a structural unit, namely a structural unit of sulfonic acid containing a phenyl group and hydroxyl groups, shown in the formula (I-1) (in the description) and a structural unit of sodium-3-acrylamido-3-methylbutanoate are introduced onto a polyacrylamide molecular main chain, so that the heat-resistant and salt-tolerant polymer oil-displacing agent has good high temperature resistance and salt tolerance when being applied to polymer flooding in an oil field; when acting on a high-temperature or high-salinity oil reservoir of which the temperature is higher than 80 DEG C and the formation water salinity is greater than 30000 mg.L<-1> (Ca<2+> and Mg<2+> are greater than 1665 mg.L<-1>), the polymer oil-displacing agent has the advantage that the oil recovery ratio is greatly increased in comparison with other polymer oil-displacing agents under the same conditions, so that an effective solution is provided for further improvement of the polymer flooding effect.

The invention provides a preparation method of a micro emulsion polymer for displacement control of an oil deposit deep part with high temperature and mineralization. The preparation method comprises the following steps of: on the basis of preparing the micro emulsion polymer by adopting a photopolymerication, adding 3-acrylamide group-3-methyl sodium butyrate, 2-acrylamide group-2-methyl propanesulfonic acid and other temperature-resistant salt-resisting materials and water-soluble anion monomers into a water solution containing acrylamide monomers; adding a dispersion agent; forming a water-oil mixed emulsion in a mixed medium of a surfactant and a solvent; and decomposing an initiator to initiate the emulsion for polymerizing to form the micro emulsion polymer by using a photopolymerication mode under the action of controllable temperature. By utilizing the capability of the micro emulsion polymer dispersed into injected water at any concentration, entering a stratum deep part and forming jelly under the action of the cross linking to block a pore throat to effectively block a high-permeation stripe of the stratum, the invention enlarges the swept volume of water, remarkably improves the crude oil recovery ratio for developing the oil deposit driven by water, and is applied to deep part profile control of the oil deposit with high temperature and mineralization.

The invention discloses a chemical synthesis method of valnemulin hydrochloride, which comprises the following steps of: taking refined pleuromutilin as raw material, carrying out sulfonation by paratoluensulfonyl chloride, and reacting with dimethyl cysteamine hcl, to obtain the pleuromutilin dimethyl cysteamine substitute; reacting D-valine, methyl acetoacetate and potassium hydroxide to obtain (R)-2-(1-methoxycarbonyl group-2-allyl) amino-3-methyl potassium butyrate, activating by ethyl chloroformate and reacting with the pleuromutilin dimethyl cysteamine substitute, adjusting PH value, carrying out reverse phase extraction, and carrying out freeze-drying to obtain the valnemulin hydrochloride. The method has the advantages that due to the refining of the raw material pleuromutilin, the impurities in the product can be effectively removed, and the purifying process can be simplified from the source; the carboxyl of D-valine can be activated by the ethyl chloroformate, so that the reaction is easier to carry out; and due to the pH adjustment, the reverse phase extraction, and the freeze-drying, the product can be obtained, so that the product is stable in quality, and high in purity.

The invention discloses a method for synthesizing D-valine, which comprises the following steps of: cyaniding isobutylaldehyde serving as an initiative raw material to prepare 2-amino-3-methyl-butanenitrile; performing catalytic hydrolysis by adopting inorganic base and a ketone catalyst to obtain mix spin freebase(+/-)-2-amino-3-methylbutyrylamide; resolving by using a resolving agent of dibenzoyl-L-tartaric acid (L-DBTA) in a mixed solvent of acetone and water to obtain D-2-amino-3-methylbutyrylamideL-DBTA salt solid with optical activity; and acidifying and separating the resolving agent, and performing reflux hydrolysis and refining to obtain D-2-amino-3-methyl-butanoic acid, namely D-valine. The method has the advantages that: raw materials are low in cost and easily obtained, the method is easy and convenient to operate, the cost is low, the environmental pollution is light, and the method is suitable for industrial production.

The invention relates to the technical field of oil recovery and particularly relates to an active functional polymer surfactant for oil displacement and a preparation method thereof. The polymer surfactant comprises the following raw materials: acrylamide, sodium hydroxide, sodium 2-acrylic amino-2-methyl propanesulfonate, hexadecyl dimethyl allyl ammonium chloride, sodium dodecyl benzene sulfonate, urea, sodium 3-acrylamido-3-methyl butyrate, N-vinyl-2-pyrrolidone and an initiator, wherein the initiator comprises the following components in percentage by mass based on the acrylamide: 0.0141% of sodium formate, 0.0192% of disodium ethylenediamintetraacetate, 0.2308% of low-temperature initiator, 0.0103% of potassium persulfate and 0.0102% of sodium hydrogen sulfite. The active functional polymer surfactant provided by the invention realizes efficient tackifying and is quickly dissolved in an aqueous solution, the contradiction between the tackifying property and water solubility of a polymer is solved, and the oil recovery factor is remarkably increased.

The invention discloses a deodorizing toilet cleaning agent and a preparation method thereof and relates to the technical field of cleaning agents. The deodorizing toilet cleaning agent is mainly prepared from polyvinyl alcohol, stearic acid, sodium hexametaphosphate, polyoxyethylene lauryl ether phosphate, sodium sulfate, propylene glycol monomethyl ether, hydrogen peroxide, isoborneol, 2-hydroxy-3-methylbutyrate, betaine, lauryl sodium sulfate, nonylphenol polyoxyethylene ether, water-soluble plant essential oil, deionized water and a deodorizing auxiliary. According to the cleaning agent, polyvinyl alcohol, stearic acid and the like serve as main components, the dirt removing capacity is high, soap scum, urine scale and other dirt can be removed very easily and conveniently, antibacterial and sterilizing components are lasting, and besides, the deodorizing auxiliary can further effectively and fast eliminate smelly odors and peculiar smells in a toilet and purify air.

The invention discloses amidase, a coding gene and applications thereof. The amino acid sequence of the amidase is represented by the SEQ ID No.2. The amidase gene is cloned from acid-producing Klebsiella oxytoca KCTC 1686 genome. After the expression of the amidase gene, amidase can be successfully obtained, and the amidase has the advantages of high catalytic activity, good stereo-selectivity, high expression amount, and wind substrate spectrum. The obtained amidase can be used to prepare optically-pure chiral compounds especially an important medicine intermediate 2-(4-chlorophenyl)-3-methylbutyric acid. The recombinant amidase can be used to catalyze a racemic substrate 2-(4-chlorophenyl)-3-methylbutyramide, and when the substrate conversion rate is near 50%, the optical purity of the (S)-2-(4-chlorophenyl)-3-methylbutyric acid is 98.5%.

The invention discloses an acylation reaction method for preparing 2-4-(chlorophenyl)-3-methylbutyryl chloride. The acylation reaction method comprises the following steps: adding 900-950 parts by weight of 2-4-(chlorophenyl)-3-methylbutyric acid, 10-12 parts by weight of acetic acid and 20-25 parts by weight of activated carbon into a reaction kettle, dripping 510-520 parts by weight of thionyl chloride into the reaction kettle at normal temperature, performing heat release reaction, increasing the temperature to 80 DEG C, then opening the reaction kettle, stirring, performing heat preservation for 6hours after the end of dripping of the thionyl chloride, and press-filtering out the activated carbon and other impurities to obtain a crude product 2-4-(chlorophenyl)-3-methylbutyryl chloride. According to the acylation reaction method, the activated carbon is adopted for heat absorption, so that the smooth reaction conditions can be ensured, the yield is greatly improved, the acetic acid is increased and the stable reaction conditions are ensured so as to be conductive to performing the reaction.

The invention discloses a synthesis process of compound D-2- aminoxy-3-methylbutyric acid, and belongs to the technical field of chemical synthesis. The synthesis process includes taking natural amino acid L-valine as a raw material, and then synthetizing the non-natural D-2- aminoxy-3-methylbutyric acid by steps of diazotization hydrolysis, acetyl protection, tert-butyl esterification, deacetylation, Mitsunobu reaction, dephthaloyl, tert-butyl ester hydrolysis and the like. The compound is synthetized by raw materials easy to obtain and is low-price; synthesis operations are convenient and simple, reaction conditions are mild and easy to control, reaction selectivity is good, yield is high, and accordingly the compound is suitable for industrial production.

The present invention relates to a 3-substituted-phenyl-3-merthylbutyric acid and 3-substituted-phenyl-3-merthylaldehyde derivatives, which are useful in the production of N-[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester, which is a sweetener with high sweetening potency.

Disclosed is a novel flavor-improving agent. Specifically disclosed is a flavor-improving agent which contains 3-methylbutanoic acid as an active ingredient.

A method for controlling conidial germination and mycelial growth in fungi comprising contacting a fungal cell with anti-fungal small molecules in an amount effective to reduce or inhibit conidial germination and mycelial growth. A method for controlling bark beetle infestations of pine trees comprising contacting one or more fungal cells with anti-fungal small molecules in an amount effective to reduce or inhibit conidial germination and mycelial growth. The anti-fungal small molecules are 5-(p-Bromobenzylidine)-α-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid, 2-[5-(4-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid, 2-[5-(4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid, [5-(4-isopropylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid or 2-[5-(2-chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pentanoic acid. The species of the fungal cell is selected from a group that has an obligate symbiosis with the mountain pine beetle (Dendroctonus ponderosae) and the western pine beetle (Dendroctonus brevicomis).

The present invention is related to a pork-flavor enhancer for food and soups, and contains 3-methylbutyric acid as an active ingredient.

An oil modifier is prepared from 20-50% of 3-methylbutyric acid, 20-30% of streptomyces fradiae, 5-15% of fatty acid, 10-15% of amino acid and the balance inevitable impurities. The oil modifier has the advantage of being good in use effect.

Disclosed is a continuous process for the preparation of ingenol-3-mebutate by reaction, in solution, of ingenol or ingenol anion and angelic anhydride or an equivalent angelylating agent. The continuous flow process is preferably performed in the presence of a base such as lithium hexamethyl disilazane (LiHMDS) and/or an activating agent such as dicyclohexylcarbodiimide (DCC). Also disclosed is a process for recycling the other reaction products obtained in the continuous process for preparation of ingenol-3-mebutate for formation of ingenol, which can then be recycled to form ingenol-3-mebutate.

The invention relates to a preparation method of MOC (methoxycarbonyl group)-L-tertiary leucine, in particular to a method for preparing the MOC-L-tertiary leucine by separating 2-methoxyamide-3, 3-methylbutanoic acid. The method comprises the following steps of forming two kinds of diastereoisomer amine salts by using the 2-methoxyamide-3, 3-methylbutanoic acid and a resolving agent which is an amine compound; separating the two kinds of diastereoisomer amine salts to obtain MOC-L- tertiary leucine amine salt; and performing acid dissociation on the MOC-L- tertiary leucine amine salt to obtain the MOC-L-tertiary leucine. The method is low in cost, a technology is simple and reasonable, the purity of products is high, and the method is suitable for industrial production of the MOC-L-tertiary leucine.