Organo-iodine complex

An organic iodine and complex technology, applied in the field of organic iodine complexes and novel organic iodine complexes, can solve the problems of poor stability, limited application and continuous application, carcinogenicity, etc., and achieve the effect of strong sterilization and disinfection ability.

Inactive Publication Date: 2006-09-20
曾雄飞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Iodine tincture and iodized oil are relatively poor in stability; povidone in polyvinylpyrrolidone iodine has carcinogenic effects on rats and mice, so its application, especially its continuous application, is greatly limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1. Preparation of iodine 4-methylthio-2-hydroxybutyrate.

[0059] In a 250ml round bottom flask with heating and magnetic stirring (the same below), add 100ml of ethanol, heat up to 45°C under stirring, add 15.2g of 4-methylthio-2-hydroxybutyric acid, add 2g of concentrated hydrochloric acid, and gradually Add 13.2g of iodine, stir for 160min, and remove the solvent under reduced pressure. The obtained product is detected to be iodine 4-methylthio-2-hydroxybutyrate, containing 13.0g of iodine and 15.1g of 4-methylthio-2-hydroxybutyrate .

Embodiment 2

[0060] Embodiment 2. Preparation of iodine lactate.

[0061] Equipment is with embodiment 1. Add 105ml of water to the round bottom flask, heat up to 65°C under stirring, add 18g of lactic acid, after the dissolution is complete, gradually add 25g of iodine, stir for 205min, concentrate and dry, the obtained product is identified as iodine lactic acid, containing 23.5g of iodine , containing 17.5g of lactic acid.

Embodiment 3

[0062] Example 3. Preparation of iodine 4-hydroxysalicylate.

[0063] Equipment is with embodiment 1. Add 135ml of water to the round-bottomed flask, heat up to 74°C while stirring, add 31.0g of 4-hydroxysalicylic acid, after the dissolution is complete, add 1.0g of phosphoric acid, gradually add 27.4g of iodine, stir for 110min, cool, and stand After 180 minutes, it was filtered and separated, and the obtained product was detected to contain 26.0 g of iodine and 30.0 g of 4-hydroxysalicylic acid.

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PUM

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Abstract

This invention relates to an organic iodine complex, in which iodine serves as coordination center and functional group-containing organics serve as chelating reagent. The functional groups can be amino and/or hydroxyl and/or carboxyl, and the representatives of hydroxyl- and carboxyl-containing organics are 2-hydroxy-4-methylthiobutanoic acid and 2-hydroxypropanoic acid, respectively. This invention also relates to a combination of organic iodine complex and its application in pharmacy. The combination comprises 0.3~40% organic iodine complex as active ingredient and one or more ingredients chosen from the following ones: natural aminoacyl iodine, solvent, surfactant, food additives, food and synthesized drugs. This combination can be used in preparation of drug against AIDS, white spot syndrome virus in penaeid shrimp, Taura syndrome virus; grass carp hemorrhage virus, stomatitis, pharyngitis, colpitis, tumor, digestive tract diseases in poultry, histomoniasis, coccidiosis, human digestive tract diseases and iodine deficiency diseases.

Description

technical field [0001] The present invention relates to the field of pharmacy. More specifically, the present invention relates to a novel organic iodine complex, especially the organic iodine complex, and the present invention also relates to its composition and its application in the field of pharmacy. Background technique [0002] Iodine is one of the essential nutrients for animals including humans. Iodine tincture has been used as a disinfectant for more than 160 years. Iodized oil has been included in the Pharmacopoeia of the People's Republic of China (2000 edition two, page 961) as a diagnostic drug and iodine supplement. Polyvinylpyrrolidone-iodine (PVP-I for short), also has been loaded into the Pharmacopoeia of the People's Republic of China (2000 edition two, the 996th page) as disinfectant antiseptic. Iodine tincture and iodized oil are relatively poor in stability; povidone in polyvinylpyrrolidone iodine has carcinogenic effects on rats and mice, so its appli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C323/52C07C59/115C07C59/48C07C65/10C07C229/24A61K31/195A61P3/02A61P31/00A61P1/02A61P11/02A61P11/00A61P15/02A61P35/00G01N33/50
Inventor 曾雄飞李树伟曾江曾燕
Owner 曾雄飞
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