1,2-oxinane pyrazolidone compounds and preparation method and applications thereof

Abstract

The invention discloses 1,2-oxinane pyrazolidone compounds and a preparation method and applications thereof. The 1,2-oxinane pyrazolidone compounds are shown in a formula III or a formula IV. The preparation method comprises the following steps: uniformly mixing a compound shown in a formula I and a compound shown in a formula II in a solvent and reacting in the presence of a phosphine catalyst to obtain the compounds shown in the formula III or the formula IV. The invention provides a new, simple and feasible method for synthesizing the 1,2-oxinane pyrazolidone compounds; the synthesized compounds are new compounds which are not reported in literatures; in the method disclosed by the invention, the cycloaddition reaction is adopted and the method belongs to the atom economic reaction; and the method uses organic phosphine as the catalyst rather than a transition metal catalyst, thus the product does not have heavy metal residual pollutants and has weeding effect on crabgrass and barnyard grass.

Description

technical field [0001] The invention belongs to the fields of organic synthesis and pesticide science, and relates to a 1,2-azacyclooctanopyrazolidinone compound, a preparation method and application thereof. Background technique [0002] 1,2-Azacyclooctanopyrazolidinone compounds and analogues (Formula 1) have diverse biological activities, have great research value in the fields of medicine, pesticides, etc., and have been used as herbicides, pesticides, etc. Insecticides, acetyl-CoA carboxylase inhibitors, etc. have been studied, and these compounds have received more attention from the pesticide industry because of their significant herbicidal activity. Although these 1,2-azacyclooctanopyrazolidinone compounds and their analogs play an important role in the research of biologically active molecules, relatively successful synthetic methods are still relatively rare. Therefore, the development of simple and practical efficient synthetic Methods to synthesize these compou...

AI Technical Summary

Problems solved by technology

Although these 1,2-azacyclooctanopyrazolidinone compounds and their analogs play an important role in the research of biologically active molecules, relatively successful synthetic methods are still relatively rare. Therefore, the development of simple and practical efficient synthetic Methods to synthesize these compounds and study their biological activities have been paid much attention

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