Method for industrially producing bromo-pyrazolidinic acid through micro-channel

Abstract

The invention relates to a method for industrially producing bromo-pyrazolidinic acid through a micro-channel. The method comprises the following steps: taking a 2-halogenated heterocyclic compound asa raw material; carrying out hydrazinolysis, cyclization, bromination and hydrolysis reactions in a micro-channel reactor; and carrying out acidification and filtration to obtain bromo-pyrazolidinicacid with high yield and high purity. The reaction time is greatly shortened, the safety is high, the pollution is small, pollutant emission is little, the cost is low, the post-treatment is simple, the yield of an intermediate product in each step is 80% or above, the purity of the intermediate product in each step is 90% or above, the purity of a final product is 95% or above, and the method isparticularly suitable for industrial large-scale production.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a method for the industrial production of bromopyrazolinic acid through a microchannel. Background technique [0002] Bromopyrazolidinic acid compounds are important intermediates of pesticides. Pyrazole pesticides, especially chlorantraniliprole and its derivatives, have a very significant effect on mammalian and pest ryanodine receptors. The difference in selectivity greatly improves the safety of mammals and other vertebrates. It has the characteristics of high efficiency, broad spectrum, good persistence, low toxicity, and environmental friendliness. Its production process has become a hot research topic at home and abroad. At present, the production methods of bromopyrazolidine acid compounds reported in domestic and foreign literature are generally only suitable for laboratory preparation due to long reaction time, safety, low yield, high cost and comp...

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a kind of microchannel industrial production method of bromopyrazolidinic acid on the basis of prior art, take 2-halogenated heterocyclic compound as raw material, carry out hydrazinolysis in microchannel reactor , ring cl

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