207 results about "Oxygenators" patented technology

Apparatus and methods for performing retrograde perfusion, especially during cardiopulmonary bypass operations, including dedicated pediatric scaled apparatus for retrograde perfusion of an adult human organ, organ system, or limb, especially the brain, employing small scale oxygenators and heat exchangers such as are designed for pediatric surgery; also including methods and apparatus for retrograde cerebral perfusion, using nonselective infravalvular cannulation of the superior vena cava, estimating the efficacy of cerebral perfusion by monitoring fluid flow across a valve of an internal jugular vein, modification of inflow pressure and administration of pharmacologic agents, and increasing fluid flow into a brain by occlusion of an inferior vena cava distal to its junction with an azygos vein.

The present invention claims and discloses a novel apparatus and method for efficiently cultivating cells with minimal mortality in order to harvest a maximum amount of cellular products generated by the cultivated cells. More particularly, the present invention teaches a method and a device for plating cells and causing maximum adherence of cells of interest. Furthermore, the present invention also teaches a growth substrate means that is capable of providing the largest surface area for cell adhesion and functions as an oxygenator, a depth filter and a static mixer to maximize the production of cellular products by intermittently and periodically provide sufficient oxygen and nutrients to the cells without causing cell death. The device of the present invention is economical and can be disposable thus eliminating complications caused by sterlization and is capable of periodically and intermittently provide oxygen and nutrients to cells, through controlling the amount of culture medium that comes into contact with the growth substrate means.

An extracorporeal blood circuit for use with a venous return line and an arterial line coupled to a patient. The extracorporeal blood circuit can include a venous air removal device coupled to the venous return line. The venous air removal device can perform an active air removal function. The extracorporeal blood circuit can include a sensor that determines a blood level in the venous air removal device, a purge line coupled to the venous air removal device, and a controller connected to the sensor. The controller can cause the venous air removal device to perform the active air removal function through the purge line when the blood level is less than a threshold. The extracorporeal blood circuit can further include a pump coupled to the venous air removal device, an oxygenator coupled to the pump, and a blood filter coupled to the oxygenator and the arterial line.

Disclosed is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit. The apparatus has an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus. The apparatus comprises: a core that is substantially centrally located in the apparatus and to which blood from a patient can be supplied through the inlet; a heat exchanger comprising a plurality of heat transfer elements that are arranged around the core and between which blood from the core can move radially outward; and an oxygenator comprising a plurality of gas exchange elements that are arranged around the heat exchanger and between which blood from the heat exchanger can move radially outward before exiting the apparatus through the outlet.

The invention relates to a portable liver extracorporal charging preservation apparatus for liver transplantation comprising a constant temperature water bath tank for liver storage, an oxygenator, a hepatic artery charging circulation loop and a portal vein charging circulation loop, and an intelligent control device for controlling bath tank temperature and flow capacity of charging circulation loop. The liver dual perfusion model created by the invention can carry out oxygen cycle charging to the exsomatized liver at normothermia.

An integrated centrifugal blood pump-oxygenator (1) which has a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further has an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to a gas outlet (13) and blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) with the rotational body (8) from the blood inlet (4) to the blood outlet (5). The rotational body (8) is magnetically journalled in a contact-free manner with respect to the rotor-housing (9). There is an extracorporeal life support system (1000), and a method of de-bubbling and priming a extracorporeal life support system (1000).

Described is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit, the apparatus having an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus, the apparatus comprising: a core in communication with the inlet such that blood from a patient can be supplied to the core, the core comprising a first element and a second element that interfit to define openings, wherein the elements and the openings together enhance flow of blood from the patient radially outward from the core; a heat exchanger that is arranged about the core and through which blood from the core can move radially outward; and an oxygenator that is arranged about the heat exchanger and through which blood from the heat exchanger can move radially outward before exiting the apparatus through the outlet.

A medical device for providing retrograde venous perfusion to the cerebral vasculature for treatment of global or focal cerebral ischemia is disclosed. The device includes a catheter having an infusion port at its distal end, venous drainage port(s), and an expandable occluder disposed between the infusion port and drainage port(s). The catheter can be inserted into the superior vena cava or the internal jugular vein. The catheter is attached proximally to a pump and an oxygenator with or without a cooling system. Alternatively, the device includes two catheters, each having a lumen communicating with a distal infusion port and an occluder mounted proximal to the port. The catheters can be inserted into the internal jugular veins distal to jugular venous valves. Methods of using the devices to provide retrograde venous perfusion and isolated cerebral hypothermia are disclosed.

A blood pump-oxygenator system including a housing, an impeller, a fiber bed, and a bypass channel that provides a path for blood to be recirculated through the fiber bed; a system comprising a housing, a means for drawing blood into the housing, a means for removing carbon dioxide from the blood, a means for adding oxygen to the blood, and a means for recirculating the blood back through the removing means and the adding means; and a method for oxygenating blood comprising drawing blood into a housing comprising a fiber bed, propelling blood principally in a radial direction through the fiber bed, adding oxygen to the blood as it moves through the fiber bed, and repeating the forcing and adding steps for at least a portion of the blood.

A donor organ treatment apparatus has a container for holding an organ and a perfusion liquid circuit. The perfusion circuit includes a supply conduit downstream of an oxygenator and a heat exchanger for supplying perfusion liquid from the oxygenator and the heat exchanger to an organ in the container and a return conduit upstream of the oxygenator and the heat exchanger for guiding perfusion liquid from the organ inside the container to the oxygenator and the heat exchanger. The supply conduit is provided with an outlet port coupling for connection to a perfusion catheter and the return conduit is provided with an inlet port coupling for connection to a return catheter. A method for successively perfusing an organ in-situ and ex-vivo with liquid circulating through the same perfusion circuit is also described.

Described is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit comprising: an inlet mandrel that is configured such that the blood moves radially outward from the inlet mandrel through the openings in a radial direction; a heat exchanger arranged around the inlet mandrel, wherein blood can move radially outward with the transfer of heat to or from the blood; an oxygenator arranged around the heat exchanger, wherein blood can move from the heat exchanger radially outward with the transfer of oxygen into the blood; and a housing that houses the inlet mandrel, the heat exchanger and the oxygenator, and that comprises a blood inlet in communication with the inlet mandrel in order to allow blood to enter the apparatus from the patient, and a blood outlet in communication with the oxygenator in order for blood to exit the apparatus, wherein the blood outlet is located in the housing radially outward from the inlet.

The invention relates to a fish tank control system with the sterilization, cleaning and oxygenation functions, and belongs to the technical field of fish tank waste water utilization. The fish tank control system comprises a fish tank, a sterilization filter, a control chip, a cleaner, an oxygenator and a standing chamber. A coarse filtration layer, a fine filtration layer, an adsorption layer and a sterilization chamber are arranged on the sterilization filter. A mixer is arranged on the inner side of the bottom of the sterilization chamber. An ultraviolet generator, an alum containing box and an ozone generator are respectively arranged on the outer side of the sterilization chamber. The control chip is connected with a blow-off pipe electromagnetic valve, the mixer, an ultraviolet electromagnetic switch, an ozone electromagnetic switch, an alum containing electromagnetic switch, an air pump, a one-way electromagnetic valve, a cyclotron motor, a first water pump and a second water pump. By the adoption of the fish tank control system, waste water can be filtered, sterilized and disinfected, water circulation can be automatically controlled, the fish tank can be automatically cleaned and oxygenated, the goals of recycling water and increasing the oxygen content in water are achieved, and the fish tank control system is high in sterilization speed, good in sterilization effect and convenient to use.

The present invention provides a intravascular nano-bubbling oxygenator comprises a catheter, capable of being inserted into a blood vessel to transport normal pressure to hyperbaric gas, comprising: a tube wall with one or two lumens, and an opening end wherein said tube wall partially comprises a plurality of pores; a connector; a gas transporting apparatus, and a control panel with on-line data sensors connections.

A fluid oxygenating apparatus is provided which includes a housing defining a chamber, a core positioned within the chamber including a fluid channel formed therein, and a bubble release port communicating with the outlet end of the channel. Fluid is flowed through an inlet of the channel and bubbles are released through the bubble release port. A method and system for debubbling a fluid in such an apparatus is also provided.

An apparatus for de-aering, oxygenating and controlling a temperature of blood in an extracorporeal blood circuit. The apparatus includes a housing, a manifold body, a heat exchanger, and an oxygenator. A blood inlet tangentially directs blood into a first chamber of the housing. The manifold body is disposed in a second chamber, and includes a core and a plurality of vanes that define channels. The heat exchanger is arranged around the manifold body, and the oxygenator around the heat exchanger. The channels are open to the heat exchanger. An established blood flow path includes rotational flow within the first chamber to separate air from the blood, generally longitudinal flow from the first chamber and along the channels, and generally radial flow through the heat exchanger and the oxygenator. With this construction, gross air removal occurs prior to the blood passing through the heat exchanger and oxygenator.

A closed loop vapor cycle generated by a special device formed by heat transfer and a vapor expander it is utilized to convert waste heat from conventional power systems into additional thermodynamic work, thereby improving the overall power system efficiency. Superheated vapor (i.e. steam) is instantaneously produced inside special energy transfer apparatus where waste heat is converted into fluid energy with desired thermodynamic properties. The superheated vapor is then converted into mechanical energy through special work-producing units (expanders), thereby returning a significant fraction of the energy contained in the waste heat to the power system. When the power system under consideration is an internal combustion engine the energy contained in the exhaust gases (waste heat) is transferred back to the engine through one or more expanders directly or indirectly coupled with the engine load. The energy extracted from the waste heat can also be added back to the engine by an apparatus able to enhance the availability of oxygen (oxygenators) during the combustion. In this case, the engine also improves its dynamic response and reduces its production of toxic emissions. If the engine utilizes heavy fuels (i.e. diesel engines), this device completely eliminates the formation of the highly toxic particulate (black smoke), while significantly improving engine performance. The cost of the energy required to operate the device proposed in this invention is zero since it only recuperates and utilizes energy in the form of heat that is normally discharged into the environment.

A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.

The invention relates to a photocatalytic oxidation flue gas desulfurization and denitration system of a coal-fired power plant, which belongs to the cross field of energy source engineering and environmental engineering, and is applied to simultaneous flue gas desulfurization and denitration of the coal-fired power plant. The process route of the system comprises the following steps of: preparing oxygen with more than 90% of purity by using an oxygenator, and introducing the prepared oxygen into a photo-catalyzing reaction tower for fully reacting to produce an oxidizing material as a main component; simultaneously introducing the oxidizing material and flue gas (after dust extraction) into an oxidizing reaction tower, oxidizing SO2 in the flue gas by the oxidizing material into a final product SO3, and oxidizing NO and NO2 by the oxidizing material into a final product NO3; absorbing SO3 and NO3 in the flue gas after oxidizing reaction when passing through an absorption tower; and completing the simultaneous flue gas desulfurization and denitration process. During desorbing, the obtained by-product, namely nitrate-sulfur acid is collected by a storage tank and is an industrial chemical with wide uses. The system simultaneously realizes desulfurization and denitration in one set of device (complete equipment) and has high removal efficiency and no secondary pollution.

The invention discloses a hollow fiber membrane oxygenator which is externally arranged on a heat exchange layer. The oxygenator comprises a housing and an upper end cover and a lower end cover detachably mounted on the housing. The housing includes an oxygenator housing, a hot water unit inner housing, an oxygenation unit housing and a core tube from the outside to the inside. The oxygenator shell and the hot water unit shell form a cavity of the hot water unit, the hot water unit shell and the oxygenation unit shell form a blood heat exchange cavity, and the oxygenation unit shell and the core pipe form a cavity of the oxygenation unit; The blood heat exchange chamber is communicated with the oxygenation unit through a circumferential opening. The hot water unit of the invention is arranged at the periphery of the oxygenation unit, so that not only the gas exchange efficiency can be improved, but also the temperature loss can be minimized to achieve the highest oxygenation efficiency. In addition, the temperature gradient of the oxygenator is very small, which can significantly reduce the probability of thrombosis in blood. At the same time, the blood temperature after oxygenation is close to the internal temperature of human body, which can bring better treatment experience.

The invention discloses an artificial wetland system with strengthened denitrification and dephosphorization, which consists of three parts: a regulation and hydrolysis tank, a water dripping oxygenator and an artificial wetland. The regulation and hydrolysis tank is arranged on the front part, an artificial wetland tank is arranged on the rear part, and the water dripping oxygenator is arranged on the joint of a water outlet of the regulation and hydrolysis tank and the artificial wetland tank. During the operation, sewage enters the regulation and hydrolysis tank for anoxic hydrolysis first, flows to the water dripping oxygenator for natural oxygenation after the treatment, and then enters the artificial wetland to remove organic matters through wetland fillers and plants and then is drained. The system uses lightweight concrete to process into an intermediate-layer filler of the artificial wetland, and upper-layer filler is gravel and lower-layer filler is pebble in the artificial wetland; compositions of the wetland plants orderly are canna, reed and herb of glomerate galingale; and the water dripping oxygenator uses three-dimensional elastic filler. Through the treatment of the system, the removal rate of COD, ammonia nitrogen and TP of the sewage can reach more than 85 percent; and the system has stable treatment effect and does not need power in winter.

The invention belongs to the field of medical apparatuses, and relates to an artificial heart assisting device for treating heart failure caused by acute cardiogenic shock, in particular to an in-vitro non-implantable maglev heart chamber assisting centrifugal blood pump. The in-vitro non-implantable maglev heart chamber assisting centrifugal blood pump adopts a non-bearing magnetic fluid levitation technology to substitute mechanical bearing driving of the conventional centrifugal blood pump, an impeller rotor is suspended in a magnetic field without any mechanical contact, and the position and the speed of the impeller rotor are precisely regulated by a digital signal processor system, so that damage to blood cells and visible components (platelets, blood coagulation factors and the like) of blood is reduced to the most extent; meanwhile, by a heparin coating technology applicable to the inner wall of the blood pump and the surface of the impeller rotor, coagulation and thrombosis as well as use of an anticoagulant medicine in the assisting process are further reduced, so that complications of hemorrhage of a patient during a surgery are reduced. The in-vitro non-implantable maglev heart chamber assisting centrifugal blood pump has the characteristics of being simple in structure, reliable in operation, convenient to maintain, stepless in speed regulation and the like, can be used for treating the heart failure caused by acute cardiogenic shock triggered by a variety of reasons, and in combination with an oxygenator, can also be used for assisting circulation and blood oxygenation during extracorporeal membrane oxygenation (ECMO) treatment.

A cardiopulmonary bypass device may include a first tube configured for connection to a vein and a second tube configured for connection to an artery. The device may further include a pump connected between the first and second tubes. In a first mode, the pump may pump fluid in one direction and in a second mode, the pump may pump fluid in the opposite direction. A control unit may be coupled to the pump to control its operation. Lungs may functions as the oxygenator of the cardiopulmonary bypass device.

A blood oxygenator includes an integral pneumatic pump disposed substantially within a housing thereof, an inlet blood flow redirector, and an outflow blood collector. An atrium provided at an inlet of the oxygenator promotes even delivery of blood to the oxygenator. In use, the oxygenator provides an even dispersion of blood therethrough, establishing even perfusion and reducing areas of stagnant blood flow.

The invention discloses a liver normal temperature perfusion restoration system. The system comprises a liver container. The liver container comprises a main body and an upper cover. The main body and the upper cover are fastened tightly. A silica gel flexible net is fixed to the main body of the liver container. The lower end of the main body of the liver container is provided with a blood return channel. The blood return channel is connected to a centrifugal pump by a blood storage tank. The front end of the blood storage tank is provided with a filter film. An outlet end of the centrifugal pump is connected to an oxygenator. The oxygenator is connected to an oxygen control device. A blood pipe of the oxygenator is divided into two paths by a heat exchanger, one path is used for hepatic artery perfusion by a roller pump and the other path is used for direct portal vein perfusion. Liver artery forms a pulsatile blood flow under the action of the roller pump so that physiological liver artery perfusion is simulated and bile duct cell protection is realized in perfusion. The system can keep hepatocyte aerobic metabolism at a normal temperature, realizes short-time restoration treatment on the liver and widens a liver source.

The invention provides systems and methods for exchanging gas in an oxygenator device, and methods for preparing and using such oxygenator devices. The systems and methods can be used to transfer oxygen to blood to assist lung function in a patient.

Disclosed is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit. The apparatus has an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus. The apparatus comprises at least one integrated pump that is provided in a core of the apparatus and to which blood from a patient can be supplied through the inlet; a heat exchanger comprising a plurality of heat transfer elements that are arranged around the at least one integrated pump and between which blood from the at least one integrated pump can move radially outward; an oxygenator comprising a plurality of gas exchange elements that are arranged around the heat exchanger and through which blood from the heat exchanger can move radially outward; and an optional filter arranged around the oxygenator and through which blood from the oxygenator can move radially outward before exiting the apparatus through the outlet.

Compositions, methods, kits, and apparatus are provided for delivering a macromolecular assembly such as a plasmid, virus vector, or other gene vector, to an extravascular tissue such as muscle tissue. The composition comprises the macromolecular assembly and a vascular permeability-enhancing agent. In another embodiment, the composition further comprises a vasodilating agent. The method of the invention comprises proving a vascular permeability-enhancing agent to a blood vessel and providing a macromolecular assembly to the vessel. An oxygenator useful for providing oxygen to a fluid extracorporeally prior to providing the fluid to a blood vessel of a mammal is included in the invention. Kits, apparatus, and methods for using the catheters described herein for isolating cardiac circulation, diverting caval blood flow from the right atrium, and for other purposes, are also described.

The invention discloses a closed-loop system oxygenator. The closed-loop system oxygenator comprises an oxygen production module assembly, wherein the oxygen production module assembly comprises an initial gas source delivery device, a main gas pipe and a high-concentration oxygen preparation device; the output end of the high-concentration oxygen preparation device is connected with an oxygen flow / concentration control device; the oxygen flow / concentration control device is electrically connected with a control module; the output end of the oxygen flow / concentration device is connected with an oxygen outlet through a total flow output pipe; an oxygen flow / concentration sensor is mounted on the total flow output pipe between the output end of the oxygen flow / concentration control device and the oxygen outlet; the sensor is electrically connected with a control module. The invention further provides a flow / concentration regulating closed-loop control system of the closed-loop system oxygenator. The oxygenator disclosed by the invention is controlled by the closed loop system, and has the advantages of being high in intelligent extent, capable of automatically and accurately regulating parameters of oxygen output, low in cost, long in service life, and good in user experience.