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Non-small cell adenocarcinoma tends to form in the cells along the outer part of the lungs. In the pre-cancerous stage, cells undergo genetic changes that cause the abnormal cells to grow faster.
Use of Hsap_1847317_1SS12GA_R+1 in preparation of product for detecting tumor immunotherapy resistance
PendingCN122256508AHigh precisionExcellent statistical significanceMicrobiological testing/measurementDNA/RNA fragmentationNucleotideOncology
The application discloses application of Hsap_1847317_1SS12GA_R+1 in preparation of a product for detecting tumor immunotherapy drug resistance, the immunotherapy is an immune checkpoint inhibitor treatment, and a nucleotide sequence of the Hsap_1847317_1SS12GA_R+1 is shown as SEQ ID NO. 1. In the technical scheme provided by the application, through a three-stage research process of screening-training-verification, it is found for the first time that Hsap_1847317_1SS12GA_R+1 is closely related to non-small cell lung cancer immunotherapy drug resistance, and it is confirmed that the Hsap_1847317_1SS12GA_R+1 can be used as an efficient detection marker. Research results show that in blood of patients after immunotherapy drug resistance, the expression amount of the Hsap_1847317_1SS12GA_R+1 is significantly up-regulated by about 10 times (P<0.0001), and excellent statistical significance is shown.
Owner:遵义医科大学第二附属医院