481 results about "Immune checkpoint inhibitors" patented technology

Disclosed are synthetic nanocarrier compositions and immune checkpoint inhibitor compositions and related methods for administration to a subject.

The invention is directed to a method of predicting clinical response of a patient to treatment of a cancer by an immune checkpoint pathway inhibitor, such as an anti-CTLA-4 or anti-PD-1 antibody binding compound. In one aspect the method comprises generating pre- and post-treatment clonotype profiles, determining a number of clonotypes that decrease in frequency between the first and second clonotype profiles, and predicting a lack of responsiveness in the patient to the treatment whenever the number of clonotypes that decrease in frequency is greater than a predetermined value.

The present invention is based on the identification of novel biomarkers predictive of responsiveness to anti-immune checkpoint inhibitor therapies.

The invention discloses a method for predicting sensitivity of patients with a cancer (non-small cell lung cancer) to immunotherapies, such as immunotherapy using an immune checkpoint inhibitor, by using KMT2C and TP53 genes as biomarkers, and also discloses application of a reagent, which detects the biomarkers specifically, in the preparation of kits to predict the sensitivity of patients with acancer (non-small cell lung cancer) to immunotherapies, such as immunotherapy using an immune checkpoint inhibitor. Through the combinatory consideration of TP53 and KMT2C gene mutation states herein, groups sensitive to ICIs (immune checkpoint inhibitors) can be predicted accurately from patients with NSCLC (non-small cell lung cancer), blind medication is avoided, and economy of ICI therapy isimproved.

The invention relates to compositions, kits, and methods for cancer therapy using recombinant poxviruses encoding a tumor-associated antigen in combination with antagonists or agonists of immune checkpoint inhibitors.

The present invention provides therapeutic, diagnostic, and prognostic methods for cancer. The invention provides methods of treating a cancer, methods of determining whether an individual having a cancer is likely to respond to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of predicting responsiveness of an individual having a cancer to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of selecting a therapy for an individual having a cancer, methods of providing a prognosis for an individual having a cancer, and methods of monitoring a response of an individual having a cancer, based on a blood tumor mutational burden (bTMB) score or a maximum somatic allele frequency (MSAF) from a sample (e.g., a whole blood sample, a plasma sample, a serum sample, or a combination thereof) from the individual.

Provided is a method of treating a cancer in an individual using activated T cells or PBMCs induced by antigen presenting cells (such as dendritic cells) loaded with a plurality of tumor antigen peptides. The method may further comprise administration of the antigen presenting cells loaded with the plurality of tumor antigen peptides to the individual. The methods may be used singly or in combination with an immune checkpoint inhibitor. Also provided are precision therapy methods customized for the individual using neoantigen peptides or based on the mutation load in the tumor of the individual, methods of preparing the activated T cells, methods of monitoring the treatment, methods of cloning tumor-specific T cell receptors, an isolated population of cells comprising the activated T cells, and compositions and kits useful for cancer immunotherapy.

Complexes comprising a platinum compound and an immune checkpoint inhibitor, and related methods, are generally provided. In some embodiments, the immune checkpoint inhibitor is an inhibitor for indoleamine-2,3-dioxygenase.

The invention relates to methods of treating melanoma using a herpes simplex virus in combination with an immune checkpoint inhibitor.

The present invention relates to methods of treating patients with advanced forms of cancer, such as metastatic melanoma and non-small cell lung cancer, in which X4P-001 is administered as monotherapy or in combination with immune checkpoint inhibitors, such as pembrolizumab. The methods demonstrate surprising results, including regression of disease, with comparatively little toxicity.

A tumor neoantigen load detecting device and a storage medium are provided. The detecting device includes a data acquisition unit used for acquiring sequencing data of target capturing zones of tumortissue DNA of a detection subject, control sample DNA, and tumor tissue RNA; a somatic cell mutation detecting unit used for mutation detection and annotation on the sequencing data of the tumor tissue DNA and the control sample DNA to obtain a mutant peptide segment; a fusion gene detecting unit used for subjecting the sequencing data of the tumor tissue RNA to fusion gene detection and annotation to obtain a mutant peptide segment; an HLA typing detection unit used for performing HLA typing on the sequencing data of the target capturing zones of the control sample DNA; an MHC affinity predicting unit used for predicting neoantigen for the mutant peptide segments according to an HLA typing detection result; a TNB calculating unit used for calculating TNB; and a result outputting unit usedfor outputting a TNB detection result. The device and the storage medium can be used for detecting and monitoring the tumor neoantigen load, and predicting curative effects of immune checkpoint inhibitors.

The invention belongs to the technical field of immunotherapy prognosis, and in particular relates to a method for immunotherapy prognosis of non-small cell lung cancer (NSCLC) patients. The method uses a gene NFE2L2 and/or KEAP1 as a biomarker, whether the biomarker is mutated or not is detected, and thereby the prognosis of the sensitivity of NSCLC patients to immunotherapy, especially immunotherapy with immune checkpoint inhibitors (ICIs) is performed. In addition, the invention also provides a kit including biomarker detection reagents and an application of the kit. The method or the kit of the invention can be used to accurately predict the population sensitive to ICIs immunotherapy among NSCLC patients with NFE2L2 and/or KEAP1 mutations, and thereby the effectiveness and clinical benefit of immunotherapy for such patients are improved.

The present application relates generally to genetically modified arenaviruses that are suitable vaccines against neoplastic diseases, such as cancer. The arenaviruses described herein may be suitable for vaccines and/or treatment of neoplastic diseases and/or for the use in immunotherapies. In particular, provided herein are methods and compositions for treating a neoplastic disease by administering a genetically modified arenavirus in combination with an immune checkpoint inhibitor, wherein the arenavirus has been engineered to include a nucleotide sequence encoding a tumor antigen, tumor associated antigen or antigenic fragment thereof.

The invention provides a gene combination and application thereof in preparation of a reagent for predicting prognosis of a patient treated with an immune checkpoint inhibitor. Based on the combination of 55 genes, the invention develops a tumor mutation score TMS32055 method through the gene combination, and TMS is defined as the number of genes containing non-synonymous mutations in a specific gene combination. TMS 55 is divided into 3 groups: TMS 55 is equal to 0, TMS 55 is greater than or equal to 1 and is less than or equal to 5, and TMS 55 is greater than 5. Compared with a group that TMS 55 is equal to 0, the patients of groups that TMS 55 is greater than or equal to 1 and is less than or equal to 5 and TMS 55 is greater than 5 have better prognosis and longer overall survival time.The TMS55 based on the 55-gene combination has higher prediction efficiency than TMB in predicting the overall survival after immunotherapy, and has uniform cutoff value. Therefore, the TMS55 can beused for predicting the prognosis of patients receiving immune checkpoint inhibition treatment, and is easier to popularize and apply in clinical practice.

The present invention provides a method of treating cancer with an integrin-binding-Fc fusion protein alone or in combination with IL-2 and/or an immune stimulant (i.e., an immune checkpoint stimulator), and/or an immune checkpoint inhibitor. The invention also provides composition for use in such methods.