47 results about "IMMUNE STIMULANTS" patented technology

A composition having phytoestrogenic and anti-cancer activity is described. The composition comprises wogonin, isoliquiritigenin, coumestrol, their pharmaceutically acceptable salts or esters, their selectively substituted analogs, or combinations thereof. The compositions may also include an anti-cancer agent and / or an immune stimulant. A method for treating or preventing cancer or an estrogen-related disorder includes administering a therapeutically effective amount of the compositions is described. The compositions are particularly useful in the treatment of hormone-related cancers.

Methods of inducing a cancer-specific immune response are disclosed through administration of an immune stimulant in the context of tumor cell death induction. Currently used clinical methods of inducing localized tumor cell death are modified to optimize immune response induction. One embodiment of the invention discloses pharmaceutical compositions and kits for modifying the palliative procedure of transarterial chemoembolization so as to promote uptake and presentation of tumor antigens in an immunostimulatory microenvironment, thereby allowing for induction of T cell, B cell and NK responses, which control not only local, but also systemic tumor growth and metastasis.

Methods of inducing T cell proliferation and expansion in vivo for treating conditions wherein antigen-specific T cell immune response are therapeutically desirable such as cancer, infection, inflammation, allergy and autoimmunity and for enhancing the efficacy of vaccines are provided. These methods comprise the administration of at least one CD27 agonist, preferably an agonistic CD27 antibody, alone or in association with another moiety such as immune stimulant or immune modulator such as an anti-CD40, OX-40, 4-1BB, or CTLA-4 antibody or an agent that depletes regulatory cells, or a cytokine. These mono and combination therapies may also optionally include the administration of a desired antigen such as a tumor antigen, an allergen, an autoantigen, or an antigen specific to an infectious agent or pathogen against which a T cell response (often CD8+) is desirably elicited.

The present disclosure provides compositions and methods for the delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse. The compositions comprise (i) a structure comprising an injectable polymer or scaffold comprising pores; (ii) lymphocytes disposed within the structure, (iii) at least one lymphocyte-adhesion moiety associated with the structure; and (iv) at least one lymphocyte-activating moiety associated with the structure, and optionally an immune stimulant.

A composition having phytoestrogenic and anti-cancer activity is described. The composition comprises wogonin, isoliquiritigenin, coumestrol, their pharmaceutically acceptable salts or esters, their selectively substituted analogs, or combinations thereof. The compositions may also include an anti-cancer agent and / or an immune stimulant. A method for treating or preventing cancer or an estrogen related disorder includes administering a therapeutically effective amount of the compositions is described. The compositions are particularly useful in the treatment of hormone-related cancers.

The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to HIV fusion protein. The present invention contemplates three categories of embodiments: protein or protein fragments, messenger RNA, or DNA / RNA. DNA / RNA compositions may be either naked or recombinant. The present invention further contemplates use with a variety of immune stimulants.

The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to HIV fusion protein. The present invention contemplates three categories of embodiments: protein or protein fragments, messenger RNA, or DNA / RNA. DNA / RNA compositions may be either naked or recombinant. The present invention further contemplates use with a variety of immune stimulants.

The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to at least one covalent binding site of myristate on the HIV matrix protein. The present invention contemplates three categories of embodiments: protein or protein fragments, messenger RNA, or DNA / RNA. DNA / RNA compositions may be either naked or recombinant. The present invention further contemplates use with a variety of immune stimulants.

The present invention provides a method of treating cancer with an integrin-binding-Fc fusion protein alone or in combination with IL-2 and / or an immune stimulant (i.e., an immune checkpoint stimulator), and / or an immune checkpoint inhibitor. The invention also provides composition for use in such methods.

Detoxified cobra venom and its constituent neurotoxins have been reported to have potent antiviral activity. Others have reported that snake venoms were generally immune stimulants. Recent research has revealed more specific details on the effects of detoxified venoms and isolated alpha-neurotoxins on cells of the immune system. Exposure of the immune cells to these detoxified proteins yields a strong response in the innate immune reaction that represents the immune systems initial response to infectious agents. Of particular relevance is the marked increase in the expression of genes associated with the production of gamma interferon, a potent antiviral agent and regulator of the immune response. The ability to induce this strong innate response has significant application to those with weakened immune systems where their ability to fight infection has been compromised. It also has the potential application to act as a method to protect individuals from contagious infectious agents as a substitute for anti-viral vaccines.

Provided herein are dual epitope polypeptides and electrophilic analogs thereof having a superantigenic epitope and at least one other epitope effective to induce the production of antibodies with binary specificity for the epitopes on a polypeptide antigen. Also, provided are electrophilic analogs of polyclonal B cell stimulants or lipids, polysaccharides and lipopolysaccharides or nucleotides. In addition, provided herein are methods for increasing production of binary epitope specific antibodies recognizing B cell polypeptide antigens, for stimulating production of antibodies using one or more of the polypeptides or electrophilic analogs and for isolating binary epitope specific antibodies or fragments thereof. Further provided are the antibodies so produced and methods of treating HIV using the same.

The invention provides a traditional Chinese medicine immune stimulant for preventing Eimeria tenella. The active ingredient of the traditional Chinese medicine immune stimulant comprises caulis spatholobi, sweet wormwood, rubia cordifolia, humifuse euphorbia herb, honeysuckle, belvedere fruit, garlic, java brucea fruit, the root of Chinese pulsatilla, Chinese dates, lalang grass rhizome, lantana camara, herba taxilli, sargentg loryvine, urena lobata, peach juvenile branchlet, hypericum ascyron, gentiana macrophylla, radix stemonae, semen pharbitidis, cortex ailanthi, hempleaf negundo chastetree leaf, scutellaria baicalensis and sophora flavescens. The traditional Chinese medicine immune stimulant is low in drug resistance and few in drug residue, does not have a toxic and side effect, and has a good prevention effect in the aspect of preventing an Eimeria tenella disease.

The invention relates to a preparation method of APP (Actinobacillus Pleuropneumoniae) OMVs (Outer Membrane Vesicles) and a vaccine of the APP OMVs, and belongs to the technical field of biology. The preparation method comprises the steps of culturing APP shope strains in vitro by using a culture medium which is in iron ion limit, obtaining acellular cultural supernatant after carrying out centrifugation and 0.22-[mu]m filtration treatment, and preparing the OMVs released by germs through ultracentrifugation, wherein the observation through a transmission electron microscope shows that the diameter of most OMVs is 50 to 100 nm, the OMVs are used as subunit vaccines to carry out secondary intranasal immunization on a mouse, the weight of the OMV immune mouse is increased for a long time, and the visual forms of lungs have no obvious difference from a PBS (Phosphate Buffer Saline) immune group. Meanwhile, an experiment shows that the OMVs are efficient immune stimulants, not only can high-level IgG (Immunoglobulin G) be stimulated to be generated by mouse sera, but also high-level IgA (Immunoglobulin A) can be generated in mouse lungs, mucosal immunity of the mouse lungs is effectively stimulated, and a better application prospect of using the OMVs as the subunit vaccines is expressed.

The invention discloses an immune adjuvant of a foot-and-mouth disease vaccine and application of the immune adjuvant, and belongs to the field of biological vaccines. The immune adjuvant is a 3D protein fragment of foot-and-mouth disease viruses. Experiments prove that after the expressed 3D protein fragment is compatible with antigens, animals are immunized, the immunogenicity of multi-epitope antigens can be enhanced, and high-level protective neutralizing antibodies are produced. In vitro stimulation shows that after the 3D protein fragment of the foot-and-mouth disease viruses is separately adopted or compatible with the multi-epitope antigens, lymphocyte proliferation response can be produced, namely the immune adjuvant can be used for enhancing immune response, distinguishing infection and immunizing the animals and is a good immune stimulant and a vaccine molecular marker.

A medical food composition, containing at least source of milk protein derived from milk producing animals, exposed to immune stimulants during pregnancy and lactation period, source of Curcuminoids, source of proteolytic enzymes, and source of Piperin effective to manage inflammatory response and associated pain symptoms in mammals.

The invention discloses a Nile tilapia transforming growth factor TGF-beta 1 gene, a related protein and application, and belongs to the technical field of biological genetic engineering. The nucleotide sequence of the Nile tilapia transforming growth factor TGF-beta 1 gene is expressed by SEQIDNO:1; and the amino acid sequence of the related protein TGF-beta 1 is expressed by SEQIDNO: 2. Prokaryotic expression of the mature peptide gene of the Nile tilapia transforming growth factor TGF-beta 1 is performed so that recombinant mature peptide of the Nile tilapia transforming growth factor beta 1; and after the mice are immunized by the mature peptide, corresponding polyclone antibodies can be obtained. The recombinant mature peptide of the Nile tilapia transforming growth factor beta 1 and the prepared polyclone antibodies can be further used as immune stimulants and used for scientific research.

The invention provides an immune stimulant used for improving the immunity function of piglets. The immune stimulant comprises the following raw materials: astragalus membranaceus, rhizoma atractylodis macrocephalae, angelica sinensis, fructus lycii, liriope spicata, dendrobe, fructus ziziphi jujubae, cortex mori, caulis spatholobi, turmeric, cacumen biotae, fructus gardeniae, cordate houttuynia, sweet wormwood, cyperus rotundus, resurrection lily rhizome, assorted Chinese herbal tea, fennel, myristica fragrans, walnut kernel, semen raphani and sapanwood. The immune stimulant has the advantages of rich resources, low toxicity, economy, environmental protection and the like, can improve feed conversion ratio, improves immunity and prevents diseases.

The invention discloses an epinephelus coioides antimicrobial peptide. The antimicrobial peptide is epinephelus coioides CD59 protein, and has an amino acid sequence as shown in SEQ ID NO.1, or protein having an amino acid sequence as shown in SEQ ID NO.1, which is substituted, lost and / or added with one or more amino acids and / or is terminal modified and has the same or higher activity. Experiments prove that the epinephelus coioides antimicrobial peptide can be used for inhibiting the growth activity of vibrio alginolyticus, can be applied to preparation of immune stimulant or feed additivesfor fish, especially groupers, and has a wide application prospect. The CD59 gene sequence of the epinephelus coioides is obtained for the first time, can be used for enriching the gene pool of groupers, can be applied to preparation of recombinant protein, antibacterial and bacteriostatic additive and fish immune simulants, and provides new practice foundation for physiological immune researchesof epinephelus coioides.

The present invention relates to a vaccine composed of at least one immune stimulant and radiofrequency waves using capacitive coupling and to a method, especially an in-situ and in vivo vaccination method for treatment of primary cancer and its metastases even in disseminated cell-states, which cannot be detected by presently available imaging methods or for prevention of relapse of the cancer disease, and especially for enabling and supporting the patient's own immune system to recognize and kill the cancer cells and to build up a memory to prevent relapse of a cancer disease.

The present disclosure provides compositions and methods for the delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse. The compositions comprise (i) a structure comprising an injectable polymer or scaffold comprising pores; (ii) lymphocytes disposed within the structure, (iii) at least one lymphocyte-adhesion moiety associated with the structure; and (iv) at least one lymphocyte-activating moiety associated with the structure, and optionally an immune stimulant.

Cancer is treated via a coordinated treatment regimen that use various compounds and compositions that employ a combination vaccination together with immune modulatory treatment and biasing of an immune response towards a Th1 profile.

A substance having innate immune stimulating activity is a polysaccharide, which contains 25 to 50 parts by mole of galacturonic acid, 15 to 50 parts by mole of galactose, 0 to 7 parts by mole of glucose, 0 to 30 parts by mole of arabinose, 0 to 6 parts by mole of xylose, and 3 to 15 parts by mole of rhamnose as constituent sugars. The polysaccharide has a polygalacturonic acid chain having α-1,4-linked galacturonic acid as a main chain. An innate immune stimulant can include the polysaccharide as an active component, which can be included in a food or drink.

A method for the production of an arabinoxylan-enriched preparation from a pentosan fraction derived from a wheat flour comprising the following sequential steps: mixing the pentosan fraction with water to obtain a pentosan slurry; centrifuging the slurry to obtain liquid and solid phases; and drying the liquid phase to provide the arabinoxylan-enriched preparation. Also provided are methods for the production of: a starch- and protein-enriched intermediate from wheat flour; a glucose-enriched preparation from wheat flour; and a starch- and protein-enriched material from wheat flour. Furthermore, there is provided a use of an arabinoxylan-enriched preparation in one or more of: food, immune stimulants, prebiotics, nutraceuticals, pharmaceuticals and food supplements. There is also an apparatus for the production of an arabinoxylan-enriched preparation from a pentosan fraction of wheat flour.

A method of increasing the biological activity of a purified Hsp65 - E7 fusion protein (HspE7) is provided. The method comprises admixing the HspE7 along with an immune stimulant selected from the group consisting of CpG, a TLR3 agonist such as PoIyLC, PoIyICLC, mono-phosphoryl-lipid A (MPL), MPL- trehalose 6,6'-dimycolate (MPL-TDM), and anti-CD40. A composition comprising HspE7 and one or more than one of CpG, a TLR3 agonist such as PoIyLC, PoIyICLC, MPL, MPL-TDM, and anti-CD40, and method of reducing a tumor or virus development in a mammal or subject in need thereof by using the composition are also provided.

The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.

The present invention provides a method of treating cancer with an integrin-binding-Fc fusion protein alone or in combination with IL-2 and / or an immune stimulant (i.e., an immune checkpoint stimulator), and / or an immune checkpoint inhibitor. The invention also provides composition for use in such methods.

A method for the production of an arabinoxylan-enriched preparation from a pentosan fraction derived from a wheat flour comprising the following sequential steps: mixing the pentosan fraction with water to obtain a pentosan slurry; centrifuging the slurry to obtain liquid and solid phases; and drying the liquid phase to provide the arabinoxylan-enriched preparation. Also provided are methods for the production of: a starch- and protein-enriched intermediate from wheat flour; a glucose-enriched preparation from wheat flour; and a starch- and protein-enriched material from wheat flour. Furthermore, there is provided a use of an arabinoxylan-enriched preparation in one or more of: food, immune stimulants, prebiotics, nutraceuticals, pharmaceuticals and food supplements. There is also an apparatus for the production of an arabinoxylan-enriched preparation from a pentosan fraction of wheat flour.

A method of treating or preventing a condition related to an HPV infection is provided. The method comprises administering to a subject a composition comprising a purified Hsp65-E7 fusion protein (HspE7) admixed with an immune stimulant selected from the group consisting of CpG, a TLR3 agonist such as PolyI:C, PolyICLC, mono-phosphoryl-lipid A (MPL), MPL-trehalose 6,6′-dimycolate (MPL-TDM), and anti-CD40. A composition comprising HspE7 and one or more than one of CpG, a TLR3 agonist such as PolyI:C, PolyICLC, MPL, MPL-TDM, and anti-CD40, and method of reducing a tumor or virus development in a mammal or subject in need thereof by using the composition are also provided.

The present application discloses a cell-penetrating peptide derived from Cap protein of duck circovirus and its design method and application. The amino acid sequence of the cell-penetrating peptide is: LRRRRRRRRLRIARPRRRF; the cell-penetrating peptide of this application is derived from the Capsid structural protein of duck circovirus, which can significantly improve the transmembrane efficiency of transport targets such as nucleic acid immunopotentiators. It mediates Poly(I:C) and CpG ODN into macrophages to induce interferon IFN-β transcription levels to increase nearly 4 times that of TAT, and 8 times that of immunostimulators alone. The cell-penetrating peptide Du-Cap aa18-37 of the present application is safe and efficient, can significantly improve the transmembrane efficiency, further enrich the types of cell-penetrating peptides, and can be developed into a safe and efficient gene drug and nucleic acid immunity Ideal delivery vehicle for stimulants.