3 results about "IMMUNE STIMULANTS" patented technology

A hetero-structured RNA with two 3′-overhangs and use thereof as an immune stimulant are provided.

The application relates to the technical field of medicines, and particularly discloses a novel immune stimulant, a preparation method and application thereof. The immune stimulant comprises an alpha-mannose modified imidazoquinoline derivative, an N-acetyl cysteine modified cytosine-guanine dinucleotide, a glycyrrhetinic acid-polyethylene glycol derivative, a phytic acid-glycine oligomer, a medicinal excipient and water for injection, three modified active ingredients are bridged by the phytic acid-glycine oligomer as a bridging unit, and a ternary coordination complex is formed through dynamic non-covalent coordination. The preparation method comprises the following steps: after raw materials are pretreated, the active ingredients are premixed, dissolved and solvent is recovered, then dynamic coordination reaction, ultrafiltration purification and concentration are carried out, and finally, a finished product is obtained through double-cavity preparation forming. The immune stimulant can be used for preparing a tumor immunotherapy, an anti-infection treatment, an immune deficiency disease auxiliary treatment drug or a vaccine adjuvant, and has the advantages of high active ingredient stability, good in-vivo delivery efficiency and outstanding synergistic effect.

The application discloses a kind of mannose modified graphene oxide-based nano drug delivery systems and its preparation method and application, belong to the technical field of biomedical materials and pharmaceutical preparations.The application solves the current free drug in vivo exposure shortage, lack of myeloid cell directional regulation, drug release uncontrollable and drug system biological compatibility problem.The application synthesizes mannose grafted ethylenediamine EDM, then with GO, EDM, EDC and NHS reaction, promote GO surface carboxyl and EDM amino form amide bond, obtain carrier, with DTX and Vadimezan loaded on carrier to obtain drug delivery system.The application uses GO as matrix, realizes receptor-mediated targeting nano-carrier system by surface functionalization of mannose, and it is used to deliver hydrophobic chemotherapeutic drugs and immune stimulants, which can be used for tumor treatment, including inhibiting primary tumor growth and metastasis-related lesions, and the effect is more obvious in combination with near-infrared light thermal response.