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23 results about "Arenavirus" patented technology
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An arenavirus is a negative-sense, single-stranded RNA virus that is a member of the family Arenaviridae. These viruses infect rodents and occasionally humans; arenaviruses have also been discovered which infect snakes. At least eight arenaviruses are known to cause human disease. The diseases derived from arenaviruses range in severity. Aseptic meningitis, a severe human disease that causes inflammation covering the brain and spinal cord, can arise from the lymphocytic choriomeningitis virus (LCMV) infection. Hemorrhagic fever syndromes, including Lassa fever, are derived from infections such as Guanarito virus (GTOV), Junin virus (JUNV), Lassa virus (LASV), Lujo virus (LUJV), Machupo virus (MACV), Sabia virus (SABV), or Whitewater Arroyo virus (WWAV). Arenaviruses are divided into two groups: the Old World and the New World viruses. The differences between these groups are distinguished geographically and genetically. Because of the epidemiological association with rodents, some arenaviruses and bunyaviruses are designated as roboviruses.
Method for producing an antitumoral arenavirus as well as arenavirus mutants
The invention relates to a mutant of an arenavirus having improved antitumoral properties. The invention also relates to a method of generating such an arenavirus mutant, related pharmaceutical compositions, medical uses, methods of treatment, and isolated proteins and nucleic acids.
Owner:ABALOS THERAPEUTICS GMBH
ARENA REPLICA DEFECTIVE VARIANT
The invention relates to an infectious arenavirus particle that is genetically engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but incapable of producing further infectious progeny particles in normal, non-genetically engineered cells.One or more of the four arenavirus open reading frames glycoprotein (GP), nucleoprotein (NP), matrix protein Z, and RNA-dependent RNA polymerase L are removed or mutated to prevent replication in normal cells, but still allow gene expression in arenavirus vector-infected cells, and foreign genes encoding an antigen or other protein of interest or nucleic acids that regulate host gene expression are expressed under the control of arenavirus promoters, internal ribosome entry sites, or under the control of regulatory elements that can be read by the viral RNA-dependent RNA polymerase, cellular RNA polymerase I, RNA polymerase II, or RNA polymerase III. The modified arenaviruses are useful as vaccines and therapeutic agents for a variety of diseases.
Owner:UNIVERSITY OF ZURICH
LAMP primer group for detecting mandarin fish arenavirus, kit and application
PendingCN120485433AMicrobiological testing/measurementMicroorganism based processesAquatic productMicrobiology
The invention relates to an LAMP (loop-mediated isothermal amplification) primer group for detecting a mandarin fish arenavirus, a kit and application, and relates to the technical field of biological detection. The LAMP primer comprises an outer primer F3, an outer primer B3, an inner primer FIP and an inner primer BIP, high-sensitivity and high-specificity detection on the siniperca chuatsi arenavirus can be achieved on the basis of the LAMP primer group, the detection result is high in specificity, the detection result does not react with other aquatic product related viruses, and the LAMP primer group is suitable for popularization and application of primary laboratories and field detection.
Owner:INST OF ZOOLOGY GUANGDONG ACAD OF SCI
Administering a lymphocytic choriomeningtitis virus (LCMV) with improved tumor regression properties
Owner:ABALOS THERAPEUTICS GMBH
Rat kidney cell line and application thereof
PendingCN121674327AViral antigen ingredientsMicrobiological testing/measurementLymphocytic cellTGE VACCINE
The invention belongs to the technical field of virus infection cell lines, and particularly relates to a rats kidney cell line and application thereof. Wherein the preservation number of the kidney cell line of the rats with the yellow chest is CCTCC (China Center For Type Culture Collection) NO: C2025271. The rats kidney cell line (RtK-15W) provided by the invention has multiple advantages of high sensitivity, high replication efficiency, quantitative detection, passage stability and the like on arenavirus; a reliable cell tool and an efficient, reliable and generalizable experimental platform are provided for separation and identification, in-vitro amplification, titer determination, pathogenesis research, drug screening, antibody neutralization experiment, vaccine effect evaluation and the like of arenaviruses (including lymphocytic choriomeningitis virus (LCMV) and Wenzhou virus (WENV)).
Owner:WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
Arenavirus t cell epitopes, megapools and uses thereof
PCT designated stage expiredWO2025117490A1SsRNA viruses negative-senseViral antigen ingredientsProteinoidPolynucleotide
Presented herein are compositions and methods, for detecting the presence of: an Arenavirus or an immune response relevant to an Arenavirus infection including T cells responsive to Arenavirus peptides or proteins comprising, consisting of, or consisting essentially of: one or more amino acid sequences, or a subsequence, portion, homologue, variant or derivative thereof or megapools; one or more fusion proteins; a pool of 2 or more peptides; or a polynucleotide that encodes one or more peptides or proteins, each from any amino acid sequence selected from any sequence set forth in Table 1 (SEQ ID NOS: 1 to 164), or a subsequence, portion, homologue, variant or derivative thereof. The invention further provides vaccines, diagnostics, therapies, and kits, comprising such proteins or peptides.
Owner:LA JOLLA INST FOR IMMUNOLOGY
Arenavirus formulations, methods and uses thereof
The present disclosure relates to improved liquid and lyophilized arenavirus formulations, as well as pharmaceutical compositions derived therefrom. The disclosure also relates to methods of making such arenavirus formulations, and methods of treating or preventing diseases or conditions (e.g., cancer and infectious diseases) using such arenavirus formulations and pharmaceutical compositions derived therefrom.
Owner:GILEAD SCIENCES INC
Aarenavirus formulations, methods and uses thereof
The present disclosure relates to improved liquid and lyophilized arenavirus formulations, as well as pharmaceutical compositions derived therefrom. The disclosure also relates to methods of making such arenavirus formulations, and methods of treating or preventing diseases or conditions (e.g., cancer and infectious diseases) using such arenavirus formulations and pharmaceutical compositions derived therefrom.
Owner:GILEAD SCIENCES INC
Arena virus monoclonal antibodies and uses
ActiveUS12358971B2SsRNA viruses negative-senseViral antigen ingredientsAntigenAntigen Binding Fragment
Disclosed herein are compositions comprising recombinant arenavirus monoclonal antibodies and antigen-binding fragments thereof, as well as therapeutic methods using the antibodies. In some embodiments, the antibodies provide pan-arenavirus protection against a number of arenavirus types and strains.
Owner:THE SCRIPPS RES INST +3
Fluorescent quantitative PCR (Polymerase Chain Reaction) primer group for detecting mandarin fish arenavirus and application
InactiveCN120210431AMicrobiological testing/measurementMicroorganism based processesBiochemistryBiological organism
The invention relates to a fluorescent quantitative PCR primer group for detecting mandarin fish arenavirus and application, and relates to the technical field of biological detection. The fluorescent quantitative PCR primer group comprises an amplification primer pair as shown in SEQ ID NO. 1 and SEQ ID NO. 2, and a probe as shown in SEQ ID NO. 3. On the basis of the fluorescent quantitative PCR primer group, the mandarin fish arenavirus MFAV can be well amplified and detected, the detection result has good specificity and sensitivity, cross reaction with other viruses capable of infecting mandarin fish except the mandarin fish arenavirus is avoided, and the lowest detection concentration is 2.20 * 10 < 2 > copies / mu L.
Owner:INST OF ZOOLOGY GUANGDONG ACAD OF SCI
Method for producing an antitumoral arenavirus as well as arenavirus mutants
Owner:ABALOS THERAPEUTICS GMBH
Modified arenavirus particles expressing cancer testis antigens as cancer immunotherapies
PCT designated stageWO2025191169A1SsRNA viruses negative-senseTumor rejection antigen precursorsDiseaseStage melanoma
The present disclosure relates to genetically modified arenaviruses suitable for the treatment of neoplastic diseases, such as cancer. The arenaviruses described herein may be suitable for treatment of neoplastic diseases and / or for the use in immunotherapies. In particular, provided herein are methods and compositions for treating a neoplastic disease by administering a genetically modified arenavirus, wherein the arenavirus has been engineered to include a nucleotide sequence encoding one or more antigenic fragment(s) of one or more cancer testis antigens (CTAs), including members of the melanoma-associated antigen (MAGE) family and preferentially expressed antigen in melanoma (PRAME). Specifically, provided herein is a genetically modified arenavirus, wherein the arenavirus has been engineered to include a nucleotide sequence encoding antigen fragments and / or epitopes of PRAME, MAGE-A3, MAGE-A4 and MAGE-A6.
Owner:HOOKIPA BIOTECH GMBH
A benzimidazole compound and its preparation method and application
The present invention provides a benzimidazole compound, a preparation method, and an application thereof. The structural formula of the benzimidazole compound is shown below, and the benzimidazole compound is a Z-isomer, wherein R1 is selected from C1-C10 alkyl, C1-C10 alkoxy, C1-C10 haloalkoxy, C1-C10 haloalkyl, C1-C10 hydroxyalkyl, and cyano. The benzimidazole compound has a strong inhibitory effect on arenaviruses, low cytotoxicity, and a high selectivity index, and can be used to prepare anti-arenavirus drugs. The preparation method is stable, simple to operate, reproducible, and has controllable quality.
Owner:ACADEMY OF MILITARY MEDICAL SCIENCES
HEPATITIS B VIRUS VACCINATION
The present application provides immunotherapies for hepatitis B virus infections. Provided herein are genetically modified arenavirus vectors suitable as vaccines for preventing and treating hepatitis B virus infections. Also provided herein are pharmaceutical compositions and methods for treating hepatitis B virus infections. Specifically, provided herein are pharmaceutical compositions, vaccines, and methods for treating hepatitis B virus infection.
Owner:HOOKIPA BIOTECH GMBH
Method for preparing anti-tumor arenavirus and arenavirus mutant
The invention relates to an arenavirus mutant with improved anti-tumor characteristics. The invention also relates to a method of producing such arenavirus mutants, related pharmaceutical compositions, medical uses, methods of treatment and isolated proteins and nucleic acids.
Owner:ABALOS THERAPEUTICS GMBH
Compounds for treating arenavirus infections
Compounds exemplified by Compound A are useful in the treatment of arenavirus infections and viral infections mediated by arenavirus glycoproteins.
Owner:ARISAN THERAPEUTICS INC
Monoclonal antibody and single-chain antibody for resisting arenavirus NP protein as well as construction method and application of monoclonal antibody and single-chain antibody
PendingCN121203009AImmunoglobulins against virusesMicroorganism based processesAntigenSingle-Chain Antibodies
The invention relates to the technical field of biological medicine, and discloses an anti-arenavirus NP protein monoclonal antibody, an anti-arenavirus NP protein single-chain antibody and a construction method and application of the anti-arenavirus NP protein single-chain antibody, the amino acid sequence of a heavy chain variable region of the monoclonal antibody is shown as SEQ ID NO: 1, and the amino acid sequence of a light chain variable region of the monoclonal antibody is shown as SEQ ID NO: 2. The invention provides a novel specific monoclonal antibody, the affinity of the monoclonal antibody to the arenavirus NP protein is strong, the monoclonal antibody can specifically recognize the NP protein and a new isolated strain, and the blank of an efficient antibody for the arenavirus NP protein with an unpublished sequence in the prior art is filled. Based on the sequence of the monoclonal antibody, the invention also designs a single-chain antibody, and the single-chain antibody has good stability and antigen (arenavirus) binding activity.
Owner:HUBEI UNIV
Replication-defective arenavirus vectors
The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic information in infected cells but unable to produce further infectious progeny particles in normal, not genetically engineered cells. One or more of the four arenavirus open reading frames glycoprotein (GP), nucleoprotein (NP), matrix protein Z and RNA-dependent RNA polymerase L are removed or mutated to prevent replication in normal cells but still allowing gene expression in arenavirus vector-infected cells, and foreign genes coding for an antigen or other protein of interest or nucleic acids modulating host gene expression are expressed under control of the arenavirus promoters, internal ribosome entry sites or under control of regulatory elements that can be read by the viral RNA-dependent RNA polymerase, cellular RNA polymerase I, RNA polymerase II or RNA polymerase III. The modified arenaviruses are useful as vaccines and therapeutic agents for a variety of diseases.
Owner:UNIVERSITY OF ZURICH
Three-fragment arenavirus as vaccine vector
The present application relates to arenavirus having an open reading frame ("ORF") rearrangement in its genome. In particular, described herein are modified arenavirus genomic fragments, where the arenavirus genomic fragments are engineered to carry a viral ORF at a position other than the wild-type position of the ORF. Also described herein are three-fragment arenavirus particles comprising one L fragment and two S fragments, or two L fragments and one S fragment. The arenaviruses described herein may be suitable for vaccines and / or treatment of diseases and / or for immunotherapy.
Owner:UNIVERSITY OF GENEVA
Compounds for the treatment of arenavirus infection
Compounds as exemplified by compound A are useful in the treatment of arenavirus infections and viral infections mediated by arenavirus glycoproteins.
Owner:ARISAN THERAPEUTICS INC
Vaccine against hepatitis b virus
ActiveCN115948467BSsRNA viruses negative-senseAntibody mimetics/scaffoldsHepatitis B immunizationPharmaceutical drug
The present application provides immunotherapy for hepatitis B virus infection. Provided herein are genetically modified arenavirus vectors suitable as vaccines for the prevention and treatment of hepatitis B virus infection. Also provided herein are pharmaceutical compositions and methods for the treatment of hepatitis B virus infection. In particular, provided herein are pharmaceutical compositions, vaccines, and methods of treating hepatitis B virus infection.
Owner:GILEAD SCIENCES INC
Lassavirus vaccines
ActiveUS12558410B2SsRNA viruses negative-senseSsRNA viruses positive-senseViral glycoproteinNucleotide
The present invention relates to polynucleotides comprising a sequence of a live, infectious, attenuated Flavivirus wherein a nucleotide sequence encoding at least a part of a arenavirus glycoprotein protein is located at the intergenic region between the E and NS1 gene of said Flavivirus, such that a chimeric virus is expressed, characterised in that the encoded sequence C terminally of the E protein of said Flavivirus and N terminally of the signal peptide of the NS1 protein of said Flavivirus comprises in the following order: —a further signal peptide of a Flavivirus NS1 protein, —an arenavirus Glycoprotein protein lacking the N terminal signal sequence and the GP2 transmembrane domain, —a TM1 and TM2 domain of a flaviviral E protein.
Owner:KATHOLIEKE UNIV LEUVEN
Three-segmented arenavirus as vaccine vector
To provide an arenavirus having reconstitution of ORF in a genome.SOLUTION: Provided is a three-segmented arenavirus particle including one L segment and two S segments in which one of the two S segments is selected from the group consisting of: (i) an S segment in which ORF encoding NP is under the control of arenavirus 5'UTR; (ii) an S segment in which ORF encoding Z protein is under the control of arenavirus 5'UTR; (iii) an S segment in which ORF encoding L protein is under the control of arenavirus 5'UTR; (iv) an S segment in which ORF encoding GP is under the control of arenavirus 3'UTR; (v) an S segment in which ORF encoding L is under the control of arenavirus 3'UTR; and (vi) an S segment in which ORF encoding Z protein is under the control of arenavirus 3'UTR.SELECTED DRAWING: Figure 1
Owner:ウニヴァシテデジュネーブ