291 results about "Platinum Compound" patented technology

The invention is directed to biocompatible conjugated polymer nanoparticles including a copolymer backbone, a plurality of sidechains covalently linked to said backbone, and a plurality of platinum compounds dissociably linked to said backbone. The invention is also directed to dicarbonyl-lipid compounds wherein a platinum compound is dissociably linked to the dicarbonyl compound. The invention is also directed to methods of treating cancer or metastasis. The methods includes selecting a subject in need of treatment for cancer or metastasis and administering to the subject an effective amount of any of the nanoparticles, compounds, or compositions of the invention.

A composite medicine for treating solid tumor by locally putting it in the tumor is composed of the active anticancer components (Pt compound and its synergist choosen from taxol-type anticancer medicine, antineoplastic antibiotic and antimetabolitic medicine), and the medicinal auxiliary (biocompatible and biodegradable high-molecular polymer).

The preparation process of fireproof silicone rubber includes the following steps: mixing silicone rubber with high vinyl group content and silicone rubber with low vinyl group content in double-roller opened mixer for 3-5 min while adding hydrogenous silicone oil and hydroxyl silicone oil; adding vapor phase white carbon black and mixing for 20-40 min to prepare high tearing silicone rubber mixture; adding aluminum hydroxide and magnesium hydroxide and mixing homogeneously; heat treatment at 140-180 deg.c for 1-4 hr and cooling; mixing for the second time, adding sulfurizing agent and platinum compound or fluoride and sulfurizing in a plate sulfurizing machine at 160-180 deg.c for 15-40 min to form rubber sheet; and sulfurizing in a stove at 160-200 deg.c for 1-4 hr. The prepared silicone rubber has excellent tearing resisting performance and fireproof performance, and may be used widely in electronic, electric, automobile, mechanical and other fields.

Provided is a method for treating a patient having cancer. The method includes administering high potency lipid-platinum compound formulations to the patient's respiratory tract. Also provided is a method of reducing treatment times for administering platinum compound formulations to a patient in need thereof by administering high potency lipid-platinum compound formulations to the patient.

The invention relates to a flame-retardant silicone rubber composition and a preparation method thereof. In the method, hydroxides are added into a silicone rubber composition, and a platinum compound and a synergist are used as flame retardants, so that the flame-retardant silicone rubber compound composition which has high flame retardant property, mechanical property and processing property and low raw material cost is prepared.

The invention discloses ceramic flame-retardant and fireproof silicone rubber and a preparation method thereof. The silicone rubber contains the following components in parts by weight: 100 parts of raw silicone rubber, 10-50 parts of white carbon black, 10-100 parts of aluminum hydroxide, 10-50 parts of low-melting-point glass powder, 10-100 parts of sericite powder, 1-20 parts of hydroxyl silicone oil, 1-20 parts of hexamethyl disilazane, 0.1-3 parts of a platinum compound and 0.1-5 parts of a vulcanizing agent. The silicone rubber is good in flame retardance, excellent in mechanical property, safe and environmentally friendly, has good mechanical strength and insulating property after being ablated, is capable of preventing burnt objects from being damaged and keeping a circuit completefor a long time and can play a good fireproof role.

The invention discloses ceramic silicone rubber. The ceramic silicone rubber contains the following materials in parts by weight: 100 parts of silicon rubber, 1-100 parts of silica, 0-30 parts of silicone oil, 0.00001-10 parts of platinum in platinum complex or platinum compound, 0-10 parts of coupling agent, 1-150 parts of ceramic powder and 0.01-10 parts of vulcanizing agent. A preparation method of the ceramic silicone rubber comprises the steps of milling the materials in a kneader, vacuumizing, milling uniformly to form lumpish ceramic rubber, cooling, adding the vulcanizing agent, and carrying out open milling, thereby obtaining the ceramic silicone rubber. The ceramic silicone rubber is easy to process and low in production cost and can be ablated into a ceramic-like shell, so as to protect an ablated object from being damaged. According to the ceramic silicone rubber disclosed by the invention, due to the addition of the platinum complex or platinum compound, the sintering temperature for the ceramic silicone rubber can be lowered, and the reaction rate during the preparation of the ceramic silicone rubber can be increased, so that the production efficiency is increased, and the production cost is reduced.

The invention discloses a ceramic composite material. The ceramic composite material contains the following materials in parts by weight: 100 parts of polyolefine, 0-100 parts of silicon rubber, 1-100 parts of silica, 0-30 parts of silicone oil, 0.00001-10 parts of platinum in platinum complex or platinum compound, 0-10 parts of coupling agent, 1-250 parts of ceramic powder, 0-10 parts of antioxidant and 0.01-10 parts of vulcanizing agent. A preparation method of the ceramic composite material comprises the steps of milling the materials in a kneader, vacuumizing, adding into the kneader, milling uniformly to form lumpish ceramic rubber, cooling, adding the vulcanizing agent, and carrying out open milling, thereby obtaining the ceramic composite material. The ceramic composite material is easy to process and low in production cost and can be ablated into a ceramic-like shell, so as to protect an ablated object from being damaged. According to the ceramic composite material disclosed by the invention, due to the addition of the platinum complex or platinum compound, the sintering temperature for the ceramic composite material can be lowered, and the reaction rate of preparation can be increased, so that the production efficiency is increased, and the production cost is reduced.

A deodorant composition comprising (i) a metallic deodorizing agent selected from copper, zinc, silver, platinum, nickel, iron, cobalt, a copper compound, a zinc compound, a silver compound, a platinum compound, a nickel compound, an iron compound, a cobalt compound and a mixture thereof, (ii) an carboxylic group-containing gelling polymer; and a liquid media. The deodorant composition has a three-dimensional shape selected from a block shape, a sphere shape, an ellipsoid shape, a cone shape and a cylinder shape and has a surface area of from about 24 mm² to about 24 mm².

The invention provides a liquid organosilicon lubricating grease composition, which is cast between a heating element and a heat radiation element and then solidified, thereby improving thermometric conductivity and simultaneously maintaining allocation performance of organosilicon lubricating grease composition with heat conductivity. The organosilicon lubricating grease composition with heat conductivity contains the following substances: 25 DEG C, viscosity 50-1000 Pa.s: (A) organopolysiloxane containing more than two alkenyl groups in one molecule; (B) organic hydrogen polysiloxane showed in general formula (1); (C) organic hydrogen polysiloxane showed in general formula (2); (D) bulking agent with heat conductivity, whose thermometric conductivity is more than 10W/m DEG C; (E) catalyst selected from platinum and platinum compound; (F) control agent selected from acetylenic compound, nitrogen compound, organic phosphorus compound, oxime compound and organic chloride compound; (G) volatile solvent for dispersing or dissolving ingredients mentioned above and the boiling point is 80-360 DEG C.

The invention relates to the technical field of adhesives, in particular to an adhesive. The adhesive is prepared from the following components: one or more of 10 to 90 weight parts of a silica gel substrate, 10 to 90 weight parts of a modified epoxy glue substrate and 10 to 90 weight parts of acrylate adhesive; 0 to 20 weight parts of a crosslinking agent, 0 to 10 weight parts of a platinum compound, 0 to 15 weight parts of an additive, 0 to 10 weight parts of a reaction inhibitor, 0 to 50 weight parts of a reinforcing material and 150 to 500 weight parts of a conductive filler. By selectionof one or more of the silica gel substrate, the modified epoxy glue substrate and the acrylate adhesive, the hardness of the adhesive can be reduced, and the weather fastness of the adhesive can be improved; meanwhile, the adhesive has the advantage of high disperse stress and is excellent in adhesiveness and protectiveness for an adhered material with low intensity. Furthermore, by use of the conductive filler, the cost of the adhesive can be effectively reduced.

The invention discloses a Pdx@Pt/C core-shell structure cathode catalyst for a fuel cell and a preparation method of the Pdx@Pt/C core-shell structure cathode catalyst. The method comprises the following steps: (1) adding a palladium precursor and a conductive carrier to N,N-dimethyl formamide or ethanol, carrying out ultrasonic mixing, and then adding borane.N,N-diethyl aniline or sodium borohydride, reacting at a room temperature for 0.5-1.5h, carrying out centrifugal washing and vacuum drying and then obtaining a carbon-supported Pd catalyst, namely Pd/C; and (2) ultrasonically dispersing the Pd/C prepared in the step (1) into a formic acid solution with the concentration of 1-5ml formic acid/20ml water, adding a water solution of a platinum compound at the atomic ratio of Pt to Pd being 1 to 1 or 1 to 2 or 1 to 3, reacting at the room temperature for 2-6h, and carrying out centrifugal washing and vacuum drying to obtain the product. The catalyst with high catalytic activity and stability is prepared by a primary cell reaction principle; the catalyst is lower than a pure Pt catalyst in cost; the preparation method is simple, convenient, mild in condition and easy to operate; and the problem that a high temperature and a surfactant are required for preparation of the core-shell structure catalyst by a conventional chemical reduction method is solved.

Disclosed is a pharmaceutical composition for solid tumour which comprises anticancer available composition and medicinal adjuvant, the anticancer available composition is platinum compounds, and the medicinal adjuvant mainly employs biological compactable, degradable and absorbable macromolecular polymer. The composition can lower down the whole body toxicity reaction of the medicament when locally dispensing on the tumor, selectively increase the tumor local medicinal concentration, and improve the treatment effect of the non-operative treatment methods such as chemotherapy, medicament and radiation.

The invention discloses a ceramifiable silicone rubber thermal protection material and a preparation method thereof, and belongs to the field of thermal protection materials. The silicone rubber composite material comprises the following components in parts by weight: 100 parts of base rubber, 10-30 parts of a reinforcing agent, 5-20 parts of a halogen-free flame retardant, 0-25 parts of a first ceramic-forming sintering auxiliary agent, 0-40 parts of a second ceramic-forming sintering auxiliary agent, 0.01-10 parts of a platinum complex or a platinum compound (calculated as platinum), and 1-5parts of a constitution controller. According to the method disclosed by the invention, through cooperation of a combination of the two ceramic-forming sintering auxiliary agents, especially througha cooperation of a combination of a transition metal oxide with one or more selected from a layered filler and a porous filler, the ceramifiable silicone rubber thermal protection material with good flame retardance is obtained, and at the same time, the ceramifiable silicone rubber thermal protection material has excellent mechanical properties and a high mass residual rate of burnt ceramics.

The present invention relates to a method of treating cancer in a patient comprising administering to the patient intraperitoneally, a cancer treating effective amount of a lipid-based platinum compound formulation.

Various biocompatible polymers having platinum compounds conjugated thereto are prepared. Such polymers are useful for a variety of drug, biomolecule, and imaging agent delivery applications. Also disclosed are methods of using the polymers to treat, diagnose, and/or image a subject.

Complexes comprising a platinum compound and an immune checkpoint inhibitor, and related methods, are generally provided. In some embodiments, the immune checkpoint inhibitor is an inhibitor for indoleamine-2,3-dioxygenase.

A silicone rubber composition comprising an organopolysiloxane component composed of (A) an organopolysiloxane gum having an alkenyl content of 0.001-2 mol % and (B) an organopolysiloxane gum having an alkenyl content of more than 2 mol % to 20 mol %, (C) microparticulate silica, (D) platinum or a platinum compound, (E) an organosilicon compound containing a nitrogenous organic group and an unsaturated hydrocarbon group and/or a benzotriazole, and (F) a curing agent cures into electrically insulating silicone rubber having a minimized tensile permanent set, improved mechanical strength, and tracking resistance.

The invention relates to glycosylated quadrivalent platinum compounds with anticancer activity, and a preparation method and application thereof. The glycosyl group is introduced into the quadrivalent platinum parent nucleus for the first time to design and synthesize a series of novel glycosylation-modified quadrivalent platinum compounds of which the anticancer and antitumor capacities are inspected. A series of original creative researches are hopeful to obtain multiple precursor molecules which are effective for tumors, thereby providing new candidate drug molecules for the existence of the traditional bivalent platinum drugs, and also providing a new pathway for modification of the quadrivalent platinum compounds. The basically creative drug researches have important theoretical value and practical meanings for national economical and social development, health of people and the like.

In one aspect, the present invention relates to methods of treating cancer in a patient comprising administering intravenously to a patient in need thereof a cancer treating effective amount of a lipid-based platinum compound formulation wherein the concentration of the platinum compound of the lipid-based platinum compound formulation is greater than about 1.2 mg/ml.

In one aspect, the present invention relates to methods of treating cancer in a patient comprising administering intravenously to a patient in need thereof a cancer treating effective amount of a lipid-based platinum compound formulation.

A method for making a hydrocarbon oxysilyl functional polymer, which is important as a modified silicone or silicone-modified polymer, by a hydrosilylation reaction between a hydride (hydrocarbonoxy)silane compound having SiH functional groups and a polymer having olefinic or acetylenic unsaturated groups in the presence of a carboxylic acid and a catalytic amount of platinum or a platinum compound.

The invention relates to a platinum and palladium containing bimetallic catalyst, a preparation method therefor and an application of the platinum and palladium containing bimetallic catalyst. The preparation method for the catalyst comprises the following steps: (1) impregnating a carrier with a solution containing a palladium compound, and then, subjecting the impregnated carrier to baking, roasting and reduction sequentially, so as to obtain a palladic monometallic catalyst precursor; and (2) impregnating the palladic monometallic catalyst precursor obtained in the step (1) with a solution containing a platinum compound in a reducing atmosphere, and then, carrying out drying so as to remove the solvent. Compared with catalysts which are prepared in the prior art and have the same noble-metal content, the catalyst provided by the invention has better aromatic-hydrocarbon saturation activity.