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Topical cooling of spinal cord, brain, esophagus, etc. can be selectively and continuously carried out under convenient control without causing any changes in internal pressure of spinal cord cavity, brain pressure, etc. by inserting a catheter, which has no hole connecting to the outside and in which a heat-cooling medium is circulated in its inner space to thereby cool a topical site; into the spinal cord, the epidural cavity, the subdural cavity or the subarachnoid cavity of the brain or the esophageal cavity and placing therein and then circulating the heat / cooling medium within the inner space of the catheter; or using a device composed of a heat absorption member in the form of a catheter, a heat insulation member and a heat radiation member, inserting the heat absorption member in the form of a catheter into the spinal cord, the epidural cavity, the subdural cavity or the subarachnoid cavity of the brain or the esophageal cavity and placing therein and then absorbing heat from the heat absorption member and radiating the heat from the heat radiation member via the heat insulation member, thereby contributing to the treatment of spinal diseases including prevention of paraplegia accompanying thoracic aortic aneurysm surgery and the treatment of brain injury, esophageal injury and so on.

A mutant herpesvirus that can be used as a recombinant virus vector comprises (a) a mutation such that the mutant virus has a reduced ability in comparison with a parent type to cause lysis of an infected cell, and (b) an inactivating mutation in a gene essential for the production of infectious virus. An example is a HSV1 mutant lacking the essential glycoprotein gH gene and having a mutation impairing the function of gene product VP16. A heterologous gene can be carried at the site of the inactivated essential gene, e.g. a gene suitable for administering gene therapy. The vector has an increased margin of safety over known herpesvirus vectors in respect of incidence of cytopathic effects and / or risk of reversion.

A substrate storage container includes a container body for accommodating and aligning semiconductor wafers, a door which opens and closes the front of the container body and a pair of valve units disposed at the bottom of the container body for controlling gas flow. Each valve unit includes a fixed sleeve for gas flow, fitted in a rib of a through-hole of the container body, a holding sleeve fitted in the through-hole of the container body with an o-ring interposed therebetween and mated and threaded with the fixed sleeve, a check valve built between the fixed sleeve and the holding sleeve, leaving a clearance, an elastically deformable element for opening and closing the check valve, an interior lid sleeve for gas flow, opposing the check valve and supporting the elastically deformable element, and a filter interposed between the holding sleeve and the interior lid sleeve.

A device for positioning an article (2) to be wrapped by a machine has a horizontal support body (3) centrally fixed on a vertical rotation shaft (4). The device (1) is equipped with at a least one plier device (5) connected, to turn together with the rotation shaft, to support the body (3), the plier device provided with at least two jaws (6,7). An opening apparatus (8) is connected to at least one of the jaws (6,7) to hold and to release the article (2). The at least one plier device (5) is connected to the support body (3) by a respective rotation device (9) for rotating the at least one plier device (5) and of the article held thereby, around an axis almost radial in respect to the support body (3).