12 results about "Anodyne" patented technology

The invention discloses a traditional Chinese medicine liniment for treating rheumatoid arthritis and a preparation process thereof, the traditional Chinese medicine liniment is composed of a wind-dispelling and pain-relieving liquid medicine and auxiliary materials, the wind-dispelling and pain-relieving liquid medicine contains eight traditional Chinese medicines of thorny elaeagnus root, erythrina bark, kadsura longepedunculata root, waxberry root, ardisia crenata, rose mallow root, glabrous sarcandra herb and wikstroemia canescens root, and is prepared by ultrasonic extraction; the auxiliary materials comprise polyvinyl alcohol, a chitosan-acetic acid solution, glycerol, azone, methylparaben, vanillyl butyl ether and ethanol. The liniment is short in film forming time and good in stability, has excellent transdermal absorption performance and antioxidant activity, can remarkably relieve joint swelling of RA model mice, improve the pain threshold value, improve joint pathological injuries, achieve local precise long-acting administration, reduce side effects of the whole body and improve patient compliance, is suitable for clinical treatment of RA, and has a wide application prospect. The problems that an existing rheumatoid arthritis treatment medicine is large in side effect, and a traditional Chinese medicine preparation is short in efficacy duration and inconvenient to use are solved.

A chemical composition for an oral pharmaceutical product is described having a therapeutically effective amount of one or more active pharmaceutical ingredients (API) including ibuprofen in combination with a cannabidiol (CBD) isolate.

A chemical composition for an oral pharmaceutical product is described having a therapeutically effective amount of one or more active pharmaceutical ingredients (API) including acetaminophen and ibuprofen in combination with a cannabidiol (CBD) isolate.

This invention relates to compounds for treating neuropathic pain. The invention also relates to the pharmaceutical composition thereof and to methods for treating neuropathic pain.

A chemical composition for an oral pharmaceutical product is described having a therapeutically effective amount of one or more active pharmaceutical ingredients (API) including acetaminophen in combination with a cannabidiol (CBD) isolate.

The invention discloses an anti-inflammatory and analgesic medicament and a preparation process thereof, and relates to the technical field of medicaments. The defects in the prior art are overcome. The medicine for diminishing inflammation and relieving pain is prepared from the following components in parts by weight: 80 to 200g of gypsum, 80 to 200g of mirabilite, 80 to 200ml of water and 1 to 2ml of vitamin B12 injection. The preparation process of the anti-inflammatory and analgesic medicine comprises the following steps: taking the components according to the weight for later use; adding water into a boiler, boiling until boiling, sequentially adding mirabilite and gypsum powder, and slowly and uniformly stirring to obtain liquid medicine; and airing the liquid medicine to normal temperature, adding the vitamin B12 injection, and uniformly mixing with the liquid medicine. The traditional Chinese medicine preparation is safe, effective, free of toxic and side effects, free of stimulation, good in antibacterial, anti-inflammatory and repairing effects and easy to obtain raw materials, does not generate dependence after being used for a long time, has high popularization value, is short in use course of treatment and can keep negative after curing HPV for a long time, and relapse is not prone to occurring.

The invention relates to a hemophilia A perioperative period blood coagulation factor drug delivery model and application thereof, and relates to the technical field of biological information. The hemophilia A perioperative period blood coagulation factor administration model is constructed by adopting a nonlinear mixed effect modeling method based on a two-chamber model structure, and covariants of the hemophilia A perioperative period blood coagulation factor administration model comprise blood type, body weight, age, perioperative period anti-fibrinolytic drug use condition and perioperative period NSAID analgesic drug use condition NSAID. The model can be used for predicting an FVIII concentration-time curve of a clinical individual patient, and individual fine optimization of the administration dosage and the administration time is realized.

The present invention provides a novel analgesic agent. The analgesic agent contains a heterocyclic compound represented by formula (I) or a salt thereof as an active ingredient (in the formula, ring A is a 5- to 7-membered heterocycle containing one or two heteroatoms selected from among a nitrogen atom, an optionally oxidized sulfur atom, and an oxygen atom; R1, R2, R3, and R4 are each independently a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a halogen atom, an amino group, -SH, a C1-6 alkylthio group, a C2-6 alkenylthio group, a C1-6 alkyl-carbonyl group, a formyl group, a C6-10 aryl group, a C1-6 alkoxycarbonyl group, a 5- or 6-membered heteroaryl group, or an oxo group; R1 and R2 may be bonded to each other to form an optionally substituted 5- or 6-membered ring; and n is 0, 1, or 2).

The present invention belongs to the field of nanopharmaceutical technology and discloses a bone-targeted lipid nanocarrier and its preparation method. The preparation method comprises: dissolving cardiolipin, cholesterol, distearoylphosphatidylethanolamine-polyethylene glycol-amino, and an analgesic drug in anhydrous ethanol to obtain a phospholipid ethanol solution; rapidly mixing the phospholipid ethanol solution with pure water, incubating at room temperature for 10 minutes, and then dialyzing for 3 hours to obtain a solid lipid nanoparticle solution loaded with the analgesic drug. The lipid nanocarrier prepared by the preparation method of the present invention comprises a monolayer of phospholipids forming a lipophilic shell that can encapsulate a hydrophobic drug; the lipid nanocarrier can prolong the drug's blood circulation time in the body and improve the drug's bioavailability.

The invention relates to a topcially-acting pain-relief pharmaceutical composition for topical use, comprising, as an active ingredient, one or more natural or synthetic peptides from the ω-conotoxin family, or one or more functionally active natural or synthetic variants thereof, the composition being intended for use in a method for treating acute or chronic nociceptive, neuropathic or nociplastic pain, such as intense chronic inflammatory and neuropathic pain, and being characterised in that it is administered locally, via the skin, close to and at the site of the free endings in the skin of the nociceptors that innervate the skin.

Polymeric particles and scaffolds containing anesthetic agents, their use for sustained local delivery of anesthetic agents, reduction of pain killer addiction and addiction risk, and methods of fabricating and administering polymeric particles containing anesthetic agents are described herein.

The invention discloses a composition of acetaminophen and phenacetin and application thereof, and belongs to the technical field of medicines. In the composition of the acetaminophen and the phenacetin, the weight ratio of the acetaminophen to the phenacetin is 1: (0.1-2.5); the phenacetin can be used for inhibiting liver injury caused by acetaminophen. When the composition is used, even if the dosage of the acetaminophen is increased to a poisoning dosage or a lethal dosage, acute liver injury cannot be caused; compared with the single use of acetaminophen or phenacetin with the same dosage, the antipyretic and analgesic effects of acetaminophen or phenacetin are enhanced. The composition and opioid central analgesic form a compound preparation, and the analgesic effect of the compound preparation can be obviously enhanced. The composition and a plurality of Chinese herbal medicine effective components with the effects of clearing heat, detoxifying and resisting inflammation form a compound preparation, so that the hepatotoxicity of acetaminophen can be effectively prevented, and the antipyretic, analgesic and anti-inflammatory effects of acetaminophen can be enhanced.