The invention discloses seven alpha type
conotoxin peptides and applications thereof. The
peptide I has an
amino acid sequence shown as the sequence 7 in a sequence table, and the last
amino acid residue is amidated; the
peptide II has an
amino acid sequence shown as the sequence 8 in the sequence table, and the last
amino acid residue is amidated; the
peptide III has an amino acid sequence shownas the sequence 9 in the sequence table, and the last
amino acid residue is amidated; the peptide IV has an amino acid sequence shown as the sequence 10 in the sequence table, and the last amino acidresidue is amidated; the peptide V has an amino acid sequence shown as the sequence 11 in the sequence table, and the last
amino acid residue is amidated; the peptide VI has an amino acid sequence shown as the sequence 12 in the sequence table, and the last amino acid residue is amidated; and the peptide VII has an amino acid sequence shown as the sequence 13 in the sequence table. Proved by determination of activity, the seven peptides shown as a general formula I have an
analgesic effect, wherein alpha type
conotoxin peptides T-1, T-2, T-3 and T-4 have remarkable
analgesic activity, and thealpha type
conotoxin peptides T5-T7 also have remarkable
analgesic activity, and the application value on the aspect of analgesia is achieved.