Novel alpha O-conotoxin peptide GeXIVA new mutant as well as pharmaceutical composition and application thereof

An amino acid, cysteine ​​technology, applied in the fields of pharmacy, biochemistry and molecular biology and neuroscience, which can solve problems such as weak blocking activity
CN112010959AActive Publication Date: 2020-12-01HAINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HAINAN UNIVERSITY
Publication Date
2020-12-01

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Abstract

The invention belongs to the field of biochemistry, molecular biology and neurosciences, and relates to a novel alpha O-conotoxin GeXIVA mutant and a pharmaceutical composition and application thereof. Specifically, the invention relates to a separated polypeptide. The amino acid sequence of the polypeptide is obtained by removing one or more amino acids in a mother sequence or replacing one or more amino acids in the mother sequence with the same number of L-type amino acids or D-type amino acids, wherein the mother sequence is SEQ ID NO:1, SEQ ID NO:62 or SEQ ID NO:63; and the polypeptide has an activity of blocking alpha9alpha10nAChR. The polypeptide disclosed by the invention can specifically block the alpha9alpha10nAChR, and has a good application prospect in the aspects of preparinganalgesic drugs, drugs for treating related mental diseases and cancers, neuroscience tool drugs and the like.
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Description

technical field

[0001] The invention belongs to the fields of pharmacy, biochemistry, molecular biology and neuroscience, and relates to αO-conotoxin peptide GeXIVA and a series of new mutants thereof, its pharmaceutical composition, its preparation method and its application. The present invention also relates to a method for blocking nicotinic acetylcholine receptors (nAChRs), and the pharmaceutical use of the conotoxin peptide. Background technique

[0002] A variety of polypeptide toxins produced in the venom of carnivorous molluscs living in tropical oceans are called conotoxins or conopeptides. Conotoxins have the special function of specifically binding to various ion channels and receptors in animals [1] , has leapt to the first place in the study of animal toxins, and is known as the "treasure house of marine drugs" and "the untapped treasury". Conotoxins have become a hot spot in neuroscience research and new drug development.

[0003] Conotoxins have diverse th...

Claims

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