Quadruple long-acting medicine composition and application thereof to pain treatment

Abstract

The invention relates to a quadruple long-acting medicine composition and application thereof to pain treatment, in particular to the quadruple long-acting medicine composition. The medicine composition contains lappaconitine, tetrahydropalmatine, fumaric acid and succinic acid of the treatment and / or effective quantity as active ingredients. Compared with a composition formed by single ingredients or two ingredients or three ingredients, the quadruple long-acting medicine composition has the characteristics of good water solubility, good curative effect, low toxic and side effects and the like. The quadruple long-acting medicine composition can be used for preventing and / or treating diseases relevant to the pain; the pain includes tumor pain, pain of cancer patients after chemotherapy, joint pain, trauma pain, postoperative pain, inflammatory pain, pain caused by drug detoxification or drug addicition and intractable pain due to unknown reasons. The quadruple long-acting medicine composition can also be used for sedation, hypnosis, collaborative anesthesia, antiarrhythmia and the like.

Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to a quadruple long-acting pharmaceutical composition and its application in treating pain. Background technique

[0002] Aconitum sinomontanum Nakai is a kind of diterpene alkaloid extracted from the root of Aconitum sinomontanum Nakai, a plant of Ranunculaceae. Gao aconitou, also known as Andrographis aconitum, is a plant of the genus Aconitum in the family Ranunculaceae. It is warm in nature, bitter in taste, and has the functions of expelling wind and dampness, regulating qi and relieving pain, promoting blood circulation and reducing swelling. Stomach pain, bruises, etc. As the active ingredient of Gaoaconitum analgesia, Gaowujiasu is the first non-addictive analgesic drug in my country. Pharmacological studies have proved that it has strong analgesic, anti-inflammatory, local anesthesia and antiarrhythmic effects. It is especially effective for cancer pain and other intrac...

Examples

Embodiment 1

[0018] Embodiment 1 Preparation examples of sustained-release preparations, injection preparations, film preparations, spray preparations, tablets, capsules, etc.

[0019] Sustained release preparation

[0020] 【Active ingredients】therapeutic and / or preventive effective doses of urcin, fumaric acid and succinic acid; in parts by weight, preferably 1-5 parts of urcin, 1-5 parts of ketalin, and fumaric acid 2-7 parts, 2-7 parts of succinic acid.

[0021] [Main auxiliary materials] slow-release materials, adhesives, lubricants, commonly used carrier auxiliary materials, etc.

[0022] [Concept and principle] Sustained-release preparations refer to the release of a substance slowly and non-constantly as required in a specified release medium. Compared with the corresponding ordinary preparations, the dosing frequency is doubled or reduced compared with ordinary preparations, and A preparation that can significantly increase patient compliance; use inorganic materials as the wall ...

preparation example

[0023] [Preparation example] According to the content of [active ingredients], weigh each active ingredient separately, mix it with a solubilizer (such as Tween-80, etc.) in an amount below the allowable addition amount in the main excipients, and add an appropriate amount of water to fully dissolve it. , add emulsifier and tetraethyl orthosilicate in turn, fully stir and mix uniformly to form mixed solution A, then add solution A to the reaction device (equipped with electromagnetic stirrer, thermometer, condensing reflux device and dropping funnel), high speed (500 rpm / Minutes) Stir and shear for 10 minutes to form transparent oily colostrum. At room temperature (25°C), gradually drop the gelatin solution into the reaction device, and the main active ingredients form O / W type droplets under stirring. Wrapped in the emulsifier micelles, reacted for 2 hours, after the tetraethyl orthosilicate was fully hydrolyzed, the calcium chloride solution was added dropwise, and the activ...

Embodiment 2

[0049] Raw materials: 1 part of corygone, 1 part of tetrahydropalmatine, 2 parts of fumaric acid, 2 parts of succinic acid

[0050] According to the above parts by weight, take 10 g of homogenate, 10 g of tetrahydropalmatine, 20 g of fumaric acid, and 20 g of succinic acid, and according to the preparation method recorded in Example 1, a nanocapsule sustained-release preparation can be prepared.

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to a quadruple long-acting pharmaceutical composition and its application in treating pain. Background technique

[0002] Aconitum sinomontanum Nakai is a kind of diterpene alkaloid extracted from the root of Aconitum sinomontanum Nakai, a plant of Ranunculaceae. Gao aconitou, also known as Andrographis aconitum, is a plant of the genus Aconitum in the family Ranunculaceae. It is warm in nature, bitter in taste, and has the functions of expelling wind and dampness, regulating qi and relieving pain, promoting blood circulation and reducing swelling. Stomach pain, bruises, etc. As the active ingredient of Gaoaconitum analgesia, Gaowujiasu is the first non-addictive analgesic drug in my country. Pharmacological studies have proved that it has strong analgesic, anti-inflammatory, local anesthesia and antiarrhythmic effects. It is especially effective for cancer pain and other intrac...

Examples

Embodiment 1

[0018] Embodiment 1 Preparation examples of sustained-release preparations, injection preparations, film preparations, spray preparations, tablets, capsules, etc.

[0019] Sustained release preparation

[0020] 【Active ingredients】therapeutic and / or preventive effective doses of urcin, fumaric acid and succinic acid; in parts by weight, preferably 1-5 parts of urcin, 1-5 parts of ketalin, and fumaric acid 2-7 parts, 2-7 parts of succinic acid.

[0021] [Main auxiliary materials] slow-release materials, adhesives, lubricants, commonly used carrier auxiliary materials, etc.

[0022] [Concept and principle] Sustained-release preparations refer to the release of a substance slowly and non-constantly as required in a specified release medium. Compared with the corresponding ordinary preparations, the dosing frequency is doubled or reduced compared with ordinary preparations, and A preparation that can significantly increase patient compliance; use inorganic materials as the wall ...

preparation example

[0023] [Preparation example] According to the content of [active ingredients], weigh each active ingredient separately, mix it with a solubilizer (such as Tween-80, etc.) in an amount below the allowable addition amount in the main excipients, and add an appropriate amount of water to fully dissolve it. , add emulsifier and tetraethyl orthosilicate in turn, fully stir and mix uniformly to form mixed solution A, then add solution A to the reaction device (equipped with electromagnetic stirrer, thermometer, condensing reflux device and dropping funnel), high speed (500 rpm / Minutes) Stir and shear for 10 minutes to form transparent oily colostrum. At room temperature (25°C), gradually drop the gelatin solution into the reaction device, and the main active ingredients form O / W type droplets under stirring. Wrapped in the emulsifier micelles, reacted for 2 hours, after the tetraethyl orthosilicate was fully hydrolyzed, the calcium chloride solution was added dropwise, and the activ...

Embodiment 2

[0049] Raw materials: 1 part of corygone, 1 part of tetrahydropalmatine, 2 parts of fumaric acid, 2 parts of succinic acid

[0050] According to the above parts by weight, take 10 g of homogenate, 10 g of tetrahydropalmatine, 20 g of fumaric acid, and 20 g of succinic acid, and according to the preparation method recorded in Example 1, a nanocapsule sustained-release preparation can be prepared.

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