330 results about "Tumor pain" patented technology

A non-abusable, non-inflammatory, biocompatible, non-biodegradable, subcutaneous, polymeric implant for the prolonged, controlled release of hydromorphone with near zero-order kinetics is described. Methods of alleviating cancer pain and treating opioid drug addiction with the implant are also described.

The invention discloses a cancer pain-relieving plaster prepared by a preparation A and a preparation B, wherein the preparation A is prepared by five branches, five skins, one brick, one stone, five cores, and the like; the preparation B is prepared by poria cocos, pinellia ternate, jackinthepulpit tuber rhizome, trichosanthes kirilowii maxim, centipede, zaocys dhumnade, and the like. When the cancer pain-relieving plaster is prepared, the preparation B is added into the preparation A to be decocted for 4.5-5.5 hours, red lead is added to be mixed to pasty fluid, then cold water is added for steeping to releasing fire-toxin, water is changed once one day, and the plaster is obtained after steeping for 7 days. When the plaster is used, the plaster is coated on cotton cloth or plaster paster. The cancer pain-relieving plaster mainly aims at tumour cancers of lung cancer, gastric cancer, liver cancer, pancreatic cancer, colon caner, rectal caner, kidney cancer, bladder caner, breast cancer, cervical cancer, ovarian cancer, esophagus cancer, laryngeal cancer, and the like and is obvious in pain-relieving effect.

Use of (S,S)- or racemic reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of a pain condition selected from neuropathic pain, nociceptive pain, cancer pain, back pain, inflammatory pain, musculo-skeletal disorders, visceral pain, pain from strains / sprains, post-operative pain, posttraumatic pain, burns, renal colic, acute pain, central nervous system trauma, head pain, and orofacial pain, is disclosed. Use of (S,S)-reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of pain in a patient refractory to an alpha-2-delta ligand, and use of (S,S)- or racemic reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use as a mental performance or mood enhancer, are also disclosed.

The invention relates to a quadruple long-acting medicine composition and application thereof to pain treatment, in particular to the quadruple long-acting medicine composition. The medicine composition contains lappaconitine, tetrahydropalmatine, fumaric acid and succinic acid of the treatment and / or effective quantity as active ingredients. Compared with a composition formed by single ingredients or two ingredients or three ingredients, the quadruple long-acting medicine composition has the characteristics of good water solubility, good curative effect, low toxic and side effects and the like. The quadruple long-acting medicine composition can be used for preventing and / or treating diseases relevant to the pain; the pain includes tumor pain, pain of cancer patients after chemotherapy, joint pain, trauma pain, postoperative pain, inflammatory pain, pain caused by drug detoxification or drug addicition and intractable pain due to unknown reasons. The quadruple long-acting medicine composition can also be used for sedation, hypnosis, collaborative anesthesia, antiarrhythmia and the like.

The invention discloses a medicine composition for treating pains, which substantially comprises clematis root, Notopterygium root, pubescent angelica, root of gentian, radix saposhnikoviae, lumbricus, Drynaria fortunei, dried ginger, etc., 35 raw medicinal medicines. The medicine composition of the invention has stronger penetrating power, good transdermal adsorption, which can increase the temperature of a lesion location, improve the blood circulation, eliminate an inflammation, unblocking a dampness blocking channel and clearing off the congestion, has remarkable effects on rheumatism pains, cancer pains, stomach cold ache and all pains resulted from cervical and lumbar hyperosteogeny, traumatic injury, fascial strain, sciatica, scapulohumeral periarthritis, etc.

The invention discloses the application of koumine to the preparation of medicines for treating chronic pains and belongs to the application of gelsemium alkaloid monomer. The analgesic experiments of the koumine on chronic pains of animals prove that the koumine has potent dose-dependent analgesic effect, the analgesic potency is superior to that of the classical antipyretic-analgesic and anti-inflammatory drugs which are aspirin and indomethacin, the therapeutic index of the koumine is much higher than that of the total alkaloids of gelsemium, the koumine possibly has no tolerance, no addiction and little side effect, which indicates that the koumine has potent and low-toxicity analgesic effect, the mechanism of action of the koumine is possibly different from those of clinically common opium analgesics or aspirin analgesics, the koumine and the pharmaceutically acceptable salt thereof have the application of preparing of the medicines for treating chronic pains and have no serious disadvantages of the clinically common analgesics and can be developed into a novel analgesic which has potent analgesic effect in treating chronic pains such as inflammatory pain, neuropathic pain, cancer pain and the like, has no tolerance and addiction and little side effect, thus the koumine has bright industrialization prospect.

A medicine in the form of aerosol or spray for dropping drug or antalgic purpose is prepared from tetrodotoxic citrate or tetrodonic acetate. Its advantages are applying it via respiratory tract, high effect up to 97% or more, high safety, and no addiction.

The invention discloses a pharmaceutical composition with effects of resisting cancer and alleviating pain, which is prepared from 40 traditional Chinese medicines: toad venom, pangolin scales, centipede, scorpion, honeycomb, leech, szechuan aconite, wild aconite, arisaema tuber, tuber pinellia, euphorbia kansui, knoxia corymbosa, rhizoma sparganii, rhizoma zedoariae, polyporus umbellatus, rhubarb, amur corktree bark, baikal skullcap root and the like. The pharmaceutical composition of the invention has obvious curative effects on various cancers of early, middle and late stages, and has the efficacies of resisting cancer and inhibiting tumor, promoting blood circulation and removing stasis, removing the necrotic tissue and promoting granulation, and promoting circulation of qi and relieving pain. The pharmaceutical composition of the invention controls cancer pain by resisting cancer and inhibiting tumor, draws out cancer poison, enables the tumor to shrink and disappear to achieve the purposes of improving living quality and prolonging life, and has convenient and safe use and no toxic and side effect. The efficacies are better by pasting the pharmaceutical composition of the invention on corresponding points of a human body.

The present disclosure relates to substituted amide compounds that are inhibitors of Fatty Acid Amide Hydrolase (FAAH), their stereoisomers, tautomers, prodrugs, polymorphs, solvates, pharmaceutically acceptable salts, and pharmaceutical compositions containing them. These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of Fatty Acid Amide Hydrolase (FAAH), such as pain including acute and post operative pain, chronic pain, cancer pain, cancer chemotherapy induced pain, neuropathic pain, nociceptive pain, inflammatory pain, back pain, pain due to disease of various origin such as: diabetic neuropathy, neurotropic viral disease including human immunodeficient virus (HIV), herpes zoster such as post herpetic neuralgia; polyneuropathy, neurotoxicity, mechanical nerve injury, carpal tunnel syndrome, immunologic mechanisms like multiple sclerosis; sleep disorders, anxiety and depression disorders, inflammatory disorders, weight and eating disorders, Parkinson's disease, addiction, spasticity, hypertension or other disorders. The disclosure also relates to the process of preparation of the amide compounds. Formula (1). The present disclosure also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.

The invention relates to the field of genetic engineering and relates to a tumor targeting recombinant DNA vaccine, a preparation method thereof and application thereof. The preparation method comprises the following steps: recombining murine ubiquitin mUbi, COX-2 and a immunostimulatory DNA sequence ISS by utilizing a genetic engineering method; and inserting a fragment mUbi-ISS-COX-2-ISS at multiple cloning sites MCS of a basic vector pVAX 1 to build encoding murine ubiquitin protein mUbi and COX-2 fusion protein antigens, and linking the fusion protein antigens by a flexible joint so as toprepare the tumor targeting recombinant DNA vaccine. After the vaccine immunizes animals, an organism immune reaction can be activated, and a specific and efficient CTL reaction of the COX-2 is quickly induced in vivo so as to carry out targeting killing of tumor cells abnormally expressed by the COX-2 and fulfill the aim of targeting tumor therapy. The tumor targeting recombinant DNA vaccine hassimple preparation, high security, low production cost, large-scale production and lasting immune response, and can also be used in the fields of inflammation treatment and cancer pain treatment.

The invention provides a mussel polysaccharide. The polysaccharide content of the mussel polysaccharide is detected by an ultraviolet spectrophotometer and the polysaccharide is 55 to 90 percent based on glucose (C6H12O6). Monosaccharide components in the mussel polysaccharide, which are detected by high performance liquid chromatography, comprise the glucose, glucuronic acid, glucosamine and the like. The mussel polysaccharide is prepared by alcohol treatment, water extraction, pressure filtration, drying and other processes. Clinical verification results show that the mussel polysaccharide has definite curative effect of treating patients with syndrome of endogenous heat due to yin deficiency and the syndrome of endogenous heat due to yin deficiency accompanied with cancer pain, is convenient to take and safe, does not have any toxic or side effect and can be used for preparing medicaments for nourishing yin, clearing heat, diminishing swelling and relieving pain and the cancer pain.

The invention relates to applications of dragon's blood and a flavonoid chemical component thereof in serving as an antagonist of a capsaicin receptor TRPV1 (transient receptor potential vanilloid 1) and in preparing a medicament for treating diseases related to TRPV1 receptors, wherein the flavonoid chemical component is cochinchinenin A or a mixture of at least two of cochinchinenin A, cochinchinenin B and loureirin B. The invention also relates to a medicinal composition comprising the dragon's blood and and the flavonoid chemical component thereof. Independent component of the dragon's blood or the cochinchinenin A, or a combination of every two of the cochinchinenin A, the cochinchinenin B and the loureirin B, or a combination comprising the cochinchinenin A, the cochinchinenin B and the loureirin B has strong capsaicin receptor TRPV1 activation inhibition effect and excellent pharmacological action based on the inhibition effect, so that the dragon's blood or the flavonoid chemical component thereof serving as an active component can be used for preparing medicaments for treating or preventing TRPV1 related diseases, such as nociceptive pains, neurogenic pains, cancer pains, headache, urinary bladder functional disorder, inflammation and the like.

The invention relates to medicines, and in particular relates to a traditional Chinese medicine paste for treating cancer pain, which can used for effectively solving the problems of the existing medicine which is small in therapeutical effect and large in side effect. According to the technical scheme, the traditional Chinese medicine paste is prepared from the following raw medicinal materials: 2g to 5g of musk, 5g to 10g of calculus bovis, 15g to 30g of borneol, 20g to 40g of common monkshood mother root, 15g to 50g of radix aconiti agrestis, 5g to 15g of nux vomica, 60g to 100g of bamboo flower, 10g to 40g of ferula asafoetida, 20g to 50g of zedoary, 15g to 35g of notoginseng, 30g to 60g of edible tulip, 30g to 65g of radices trichosanthis, 20g to 55g of raw frankincense, 20g to 55g of raw myrrh, 30g to 60g of spina gleditsiae, 15g to 45g of thunberg fritillary bulb and 2g to 4g of venenum bufonis. The traditional Chinese medicine paste is suitable for the treatment of pains caused by various cancers, can be used for obviously relieving pain symptoms and has the functions of eliminating tumescence, removing stasis and reducing lump. The traditional Chinese medicine paste has a definite effect and a good application effect. Thus, the traditional Chinese medicine paste is a novel medicine used for treating the cancer pain.

The invention belongs to the technical field of medicine, and particularly relates to application of a high-optical-purity compound shown in a general formula (I) in preparation of a medicine for treating a cancer pain. R is defined in the specification. The invention also relates to a pharmaceutical composition including the compound.

The invention relates to glucagon-like peptide-1 (GLP-1) acceptor agonists (comprising: macromolecular agonists, such as GLP-1 and derivatives thereof, and exendins and derivatives thereof; and micromolecular agonists, such as geniposides) used for treating diseases, such as pains, especially chronic pains, comprising neuropathic pains, cancer pains, diabetic pains, immune inflammation pains, pains in back and loin, and the like which can be treated through activating a central nervous system comprising a spinal cord GLP-1 acceptor.

The invention discloses the application of koumine to the preparation of medicines for treating chronic pains and belongs to the application of gelsemium alkaloid monomer. The analgesic experiments of the koumine on chronic pains of animals prove that the koumine has potent dose-dependent analgesic effect, the analgesic potency is superior to that of the classical antipyretic-analgesic and anti-inflammatory drugs which are aspirin and indomethacin, the therapeutic index of the koumine is much higher than that of the total alkaloids of gelsemium, the koumine possibly has no tolerance, no addiction and little side effect, which indicates that the koumine has potent and low-toxicity analgesic effect, the mechanism of action of the koumine is possibly different from those of clinically commonopium analgesics or aspirin analgesics. The koumine and the pharmaceutically acceptable salt thereof have the application of preparing of the medicines for treating chronic pains, have no serious disadvantages of the clinically common analgesics, and can be developed into a novel analgesic which has potent analgesic effect on treating chronic pains such as inflammatory pain, neuropathic pain, cancer pain, and the like, has no tolerance and addiction and little side effect, thus the koumine has bright industrialization prospect.

The invention discloses application of human interleukin-24 gene recombined vector mediated by adenovirus in preparing a tumor analgesic medicament. The technical proposal comprises the following steps: (1) constructing recombinant transfer plasmid pAdTrack-CMV-IL-24; (2) preparing positive cloning pAdEasy-l-pAdTrack-CMV-IL-24 by the pAd-TrackhCMV-IL-24 with correct order-checking according to a conventional method; (3) carrying out virus packaging on the pAdEasy-l-pAdTrack-CMV-IL-24 gene recombinant plasmid, and obtaining high-titre recombinant adenovirion (Ad-IL-24) after multiple amplifications; and (4) infecting a tumor tissue by the Ad-IL-24. The technical proposal is combined with an analgesia test of a rat tibia cancer pain model, and results not only prove that the Ad-24 has consensual carcinostatic function, but also prove that expression of the adenovirion interleukin-24gene in a cell can play a role in inhibiting cancer pains in multiple ways.

The invention relates to a Chinese medicinal composition for treating cancerous pain, which is called as Aitongping for short. The Chinese medicinal composition is prepared from the following raw materials in portion by weight: 3 to 5 portions of drug armadillidium, 4 to 6 portions of pariphyllin, 3 to 5 portions of piper longum, 3 to 6 portions of prepared rhizoma typhonii, 1 to 3 portions of prepared frankincense, and 2 to 6 portions of prepared rhizoma arisaematis. The invention also provides a preparation method for the Aitongping. Pharmacology and medicament effect and clinical application prove that the Aitongping has good abirritation, improves the life quality of a cancerous person, has a good anticancer effect, and enhances nonspecific immunity function and cellular immune function remarkably. The remarkable clinical cure efficiency is 53 percent; and the total efficiency is 90 percent. The preparation has abundant medicinal sources, low cost, convenient medicament administration, no obvious toxic and side effect, and good development prospect.

A composite medicine for treating rheumatic and rheumatoid diseases and cancer pain is prepared from Sailonggu, snow lotus flower and safflower. Its preparing process and its quality control method are also disclosed.

The invention belongs to the field of medicine technology, particularly relates to an application of a compound having the following structural formula as described in the specification in preparation of cancer pain medicines, and also relates to a pharmaceutical composition containing the compound.

The invention discloses an application of lncRNA (long non-coding ribonucleic acid) XR595534.2 in preparation of a medicine for treating or preventing chronic pain. According to the invention, trigeminal neuralgia induced by rat suborbital nerve chronic compression injury is taken as a pain model, a long-chain non-coding RNA gene lncRNA XR595534.2 with high specificity and difference expression in the model is obtained by screening, and interfering RNA for treating diseases taking lncRNA XR59534.2 as a target point is provided. The lncRNA XR595534.2 highly expressed in specificity and difference in a pain model is discovered for the first time, expression of the lncRNA XR59534.2 can be remarkably reduced by positioning injection of interfering RNA, pain behavior reaction is relieved, and the lncRNA XR595534.2 can be used for preparing medicines for preventing or treating prosopalgia, neuropathic pain, migraine and cancer pain.

The invention provides a cancer pain plaster composed of nux vomica, Hindu datura flower, pendulous monkshood root, dried Chinese toad skin, paniculate swallowwort root or herb, yanhusuo tuber, panax notoginseng, and an auxiliary material of borneol. One plaster comprises, preferably, 1.0g of nux vomica, 1.0g of Hindu datura flower, 1.0g of pendulous monkshood root, 1.0g of dried Chinese toad skin, 1.0g of paniculate swallowwort root or herb, 2.0g of yanhusuo tuber, 1.0g of panax notoginseng, and the auxiliary material of borneol. According to the technology, authentic pure traditional Chinese medicines are selected, and scientific formulation and rigorous production process are adopted. The materials are refined, and effect is concentrated. An effect can be provided after 20min of application, and a pain-relieving effect can last for 24h. Therefore, a substantial pain-relieving effect can be provided for continuous cancer pain. Especially, the plaster has relieving and stopping effects against long-term severe pains. When the plaster is repeatedly applied, no toxic or side effect is provided, and addiction is prevented. The plaster causes no irritation or allergy to skins, and is suitable to be used against various pains caused by various cancer primary tumors and metastases. With the plaster, patient pain can be relieved, symptoms can be relieved, and substantial pain relieving effects and concentrated pain relieving functions such as blood circulation activating, stasis removing, collateral dredging, qi regulating, and stagnation eliminating are provided.

The invention discloses a capparis acutifolia sweet exact and a preparation method and an application thereof. The capparis acutifolia sweet extract is obtained by taking roots and stems of plant-capparis acutifolia sweet, smashing, then carrying out heating reflux and cold soaking or leakage for extraction, carrying out vacuum concentration for obtaining a crude extract and using chloroform for extracting the crude extract, and can be applied in the preparation of drugs for treating neuropathic pain, treating inflammatory pain, treating cancer pain, treating diabetic pain, treating rheumaticpain, treating traumatic injury pain, treating sore throat, treating toothache or treating abdominal pain, and the capparis acutifolia sweet extract has great analgesic and anti-inflammation activityand obvious effect for Freund's complete adjuvant arthritis. The preparation process is characterized by low cost and easy realization of industrial production.

The invention provides methods for preparing a benzo ring derivative with a benzylic quaternary carbon center and ethazocine hydrobromide. An aryl iodide and an alkylating agent as starting materialsare stirred for reaction in an organic solvent at 30 DEG C to 120 DEG C under the action of a palladium catalyst, a phosphine ligand, a norbornene derivative, and a base to obtain the benzo ring derivative with the benzylic quaternary carbon center. The raw materials used in the method are cheap and easy to obtain, reaction conditions are mild, substrate universality is good, yield is high, and the preparation process is simple. Meanwhile, the present invention also provides a method for synthesizing an ethazocine hydrobromide compound based on a 1,2,3,4-tetrahydronaphthalene compound having abenzylic all-carbon quaternary carbon center synthesized by the method, the drug ethazocine hydrobromide for treatment of cancer pain and post-operative pain can be synthesized only by four steps. The method has short synthetic steps, simple operation and high total yield.

The invention relates to a traditional Chinese medicine composition for treating cancer pain. The traditional Chinese medicine composition is prepared from the following raw medicines in parts by weight: 10 to 20 parts of sangusis draconis, 10 to 20 parts of borneol, 10 to 20 parts of frankincense, 10 to 20 parts of myrrh, and 10 to 20 parts of radix angelicae. The traditional Chinese medicine composition is in one of the common forms of externally-applied preparations. The traditional Chinese medicine composition has the advantages that various medicines supplement each other to realize the effects of promoting blood circulation to remove blood stasis, and eliminating stagnation and relieving pain; the effect of relieving cancer pain caused by liver cancer is obvious; the quality of life of a patient can be obviously improved; the satisfaction is high; the treatment effect is quickly achieved; in addition, the traditional Chinese medicine composition is an externally-applied preparation which is convenient to use, and the gastrointestinal reaction caused by orally taking the medicine is avoided; simultaneously, the traditional Chinese medicine is low in price and easily accepted by a patient.

The invention discloses a novel compound and a preparation method thereof, as well as a pharmaceutical composition with the compound as an active ingredient and the effects and the uses thereof. The inventive compound and the pharmaceutical composition with the compound as the active ingredient can be used for treating tumors, relieving tumor pain, and enhancing immunity.

The invention discloses a medicament for curing cancer pain and a preparation method thereof. The medicament for curing the cancer pain comprises raw materials by weight: 2-15 parts of ginseng, 5-50 parts of radix astragali, 3-20 parts of szechwan chinaberry fruit, 3-30 parts of decumbent corydalis tuber, 5-50 parts of rhizoma corydalis, 5-30 parts of radix curcumae, 5-40 parts of radix angelicae, 5-20 parts of pollen typhae, 5-20 parts of trogopterus dung, 2-20 parts of rhizoma sparganii, 2-20 parts of curcuma phaeocaulis, 1-20 parts of panax pseudoginseng, 10-50 parts of poria cocos, 10-50 parts of rhizoma atractylodis alba, 2-30 parts of szechuan lovage rhizome and 0.01-5 parts of musk. The preparation method of the medicament for curing the cancer pain is that Chinese medicine compositions including powder and capsules are prepared according to a Chinese medicine conventional preparation method. The medicament has main effects of tonifying qi, activating blood, relieving pain, removing stasis and strengthening physique and can be used for curing the cancer pain. The medicament for curing the cancer pain is a prescription created by years of clinical experiences and used for curing the cancer pain and has obvious curative effects.

The invention discloses an oral administration pharmaceutical powder for treating cancer pains which is prepared from turtle shell, house lizard, root of American ginseng, giant knotweed rhizome, pangolin scales, buthus martensi karsch, centipede, rhizoma corydalis, root of herbaceous peony, chicken's gizzard-skin, and musk by a predetermined proportions. The invention also discloses its preparing process.

Use of (S,S)- or racemic reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of a pain condition selected from neuropathic pain, nociceptive pain, cancer pain, back pain, inflammatory pain, musculo-skeletal disorders, visceral pain, pain from strains / sprains, post-operative pain, posttraumatic pain, burns, renal colic, acute pain, central nervous system trauma, head pain, and orofacial pain, is disclosed. Use of (S,S)-reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of pain in a patient refractory to an alpha-2-delta ligand, and use of (S,S)- or racemic reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use as a mental performance or mood enhancer, are also disclosed.