35 results about "Tumor pain" patented technology

The present invention relates to a voltage-gated sodium channel Nav1.8 selective inhibitor and the use thereof in the preparation of a related drug. The drug is used for treating diseases responsive to the inhibition of voltage-gated sodium channel NaV1.8, such as chronic pain, enterodynia, neuropathic pain, musculoskeletal pain, acute pain, inflammatory pain, cancer pain, idiopathic pain, post-operative pain, visceral pain, multiple sclerosis, Charcot-Marie-Tooth syndrome, incontinence, pathological cough or arrhythmia. Specifically, the present invention relates to a compound as shown in formula (X), and an isomer, nitrogen oxide, hydrate, solvate, metabolite, pharmaceutically acceptable salt or prodrug thereof.

Provided is a use of an oncolytic virus in the treatment of pain, especially in the treatment of cancer while relieving cancer pain. The drug effect time of the oncolytic virus for relieving cancer pain is obviously longer than that of the existing opioid analgesic, and the dual effects of treating cancer and easing pain are achieved at the same time.

The present invention relates to the process of enrichment of Phytocannabinoids namely CBD and Δ9-THC from the dried aerial part (leaves and inflorescence) of Cannabis sativa. The present invention also relates to the preparation of formulation having enriched CBD and THC by combining with appropriate acceptable excipients such as nutriose, dextrin and maltodextrin. The present invention also discloses the use of the phytocannabanoids enriched blend for the management of pain including cancer pain & general pain.

The present invention provides use of lncRNA XR_595534.2 in the preparation of a medicine for the treatment or prevention of chronic pain. In the present invention, trigeminal neuralgia induced by chronic constriction injury of infraorbital nerve in rats is used as a pain model. A specifically and differentially highly expressed long-chain non-coding RNA gene lncRNA XR_595534.2 is screened in the model. An interfering RNA targeting lncRNA XR_595534.2 is provided for disease treatment. The present invention discovers for the first time that lncRNA XR_595534.2, which is specifically and differentially highly expressed in a pain model, has significantly reduced expression by stereotactic injection of an interfering RNA to relieve the pain behavior, and is useful in the preparation of a medicine for the treatment or prevention of trigeminal neuralgia, neuropathic pain, migraine and cancer pain where lncRNA-XR595534.2 is a target.

The invention discloses oligopeptide and application thereof in preparation of a medicine for treating and / or relieving pain. The amino acid sequence of the oligopeptide disclosed by the invention comprises a derivative sequence formed by additionally arranging 1-3 amino acids at the N end and / or C end of the amino acid sequence shown as Tyr-Pro-Arg, especially Tyr-Pro-Arg-Arg (YPRR, YR4), and a gastrointestinal tract digestion product Tyr-Pro-Arg (YPR, YR3) of the oligopeptide. The oligopeptide not only can relieve acute pain induced by a mouse thermal drifting model, but also can relieve chronic pain induced by a rat sciatic nerve chronic compression injury model and a tibia bone cancer pain model, and meanwhile, the oligopeptide obviously inhibits CCI-induced spinal astrocyte, microglia and neuron activation; therefore, the compound has important development and application values in the aspects of central sensitization inhibition and analgesia.

The invention relates to the technical field of medicines, in particular to application of anwuligan in preparation of medicines for treating or preventing neuroinflammation related diseases and bone cancer pain. Animal experiments prove that the anwuligan can relieve nerve cell inflammatory response, inhibit tumor cell growth, prevent bone destruction caused by tumors and inhibit mechanical pain sensitivity, heat pain sensitivity and spontaneous pain of bone cancer pain rats. Results show that the anwuligan has potential anti-inflammatory, anti-cancer and analgesic effects and has an application prospect of being developed into a medicine for preventing and treating cancer pain.

The purpose of the present invention is to provide a prophylactic or therapeutic agent for cancer pain. The present invention provides a pharmaceutical composition for preventing or treating cancer pain, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. In the formula (I), m is an integer of 1-4; r1 is independently selected from a group consisting of a hydrogen atom, a halogen atom, a methyl group optionally substituted by 1-3 halogen atoms, a methoxy group optionally substituted by 1-3 halogen atoms, and a methylthio group optionally substituted by 1-3 halogen atoms.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

The invention provides a method and system for establishing a cancer pain prognosis prediction model, and the method comprises the steps: collecting cases, and selecting variable factors which need to be included in the construction of the prediction model; detecting the genotype of each SNP site by adopting gene sequencing; assigning values to dependent variable factors and independent variable factors; a prediction model is established based on Logistic regression analysis; and evaluating the prediction capability of the prediction model by using the Cox-Snell R score and the Neigore R score. The prediction model is established by detecting genotype combination analysis of SNP loci with a great cancer pain prognosis effect and combining clinical characteristics, biochemical indexes and gene detection results, individual prediction is used for each patient, cancer pain patients with poor prognosis are found timely and accurately, the drug test time is shortened, the identification speed is increased, and the detection efficiency is improved. The efficiency of determining the treatment effect of the cancer pain medicine is improved, and insufficient analgesia and serious adverse reaction are avoided.

The application discloses a polypeptide targeting palmitoylation modification of APLNR protein and application thereof in cancer pain treatment, in particular, application of APLNR protein and a palmitoylation modification site of the APLNR protein in relieving morphine tolerance in treatment of cancer pain. It is found by the application that the palmitoylation modification of APLNR is one of important response factors of neuropathic cancer pain, and a polypeptide targeting palmitoylation modification of APLNR protein is developed by taking the APLNR protein as a target, and the polypeptide is combined with morphine to treat cancer pain, so that the cancer pain can be effectively reduced, and the occurrence of morphine tolerance can be relieved, thereby providing a new strategy for clinical treatment of cancer pain and relief of morphine tolerance.

The invention discloses intelligent opioid medicine titration administration control equipment for cancer pain patients, which comprises a solid-state pump, a control panel and a working process of the control panel, and comprises the following steps: collecting real-time physiological data, and obtaining discrete data sequences of skin electrical activity, myoelectricity, respiratory rate, oxyhemoglobin saturation, heart rate and diastolic pressure; preprocessing the discrete data sequence to generate a time-index matrix; processing the time-index matrix by adopting a multi-scale morphological gradient algorithm, and extracting pain risk characteristics and metabolic influence characteristics; and processing the pain risk characteristics and the metabolic influence characteristics by adopting a multi-user orthogonal resource scheduling algorithm, and generating a control instruction containing the total dosage, the total time and the rate of the titration administration of the opioids of the solid-state pump. Therefore, key information related to pain and metabolic safety can be captured in a targeted mode, the individual state of a patient can be mastered more accurately, and the analgesic effect is optimized on the premise that medication safety is guaranteed.

The invention provides a tumor pain management system based on an artificial intelligence technology, and relates to the technical field of medical auxiliary management systems, and the system comprises a biosensing module which is used for real-time physiological and biochemical monitoring; the AI analysis module is used for analyzing the data of the biosensing module and providing analysis data; the personalized pain management module is used for performing terminal control on the analysis data of the AI analysis module; the doctor / patient interface is used for terminal control of doctors / patients; the data storage module is used for storing physiological and biochemical parameters, analysis results and pain management schemes of patients, and through cooperative work of the AI analysis module and the personalized pain management module, the system can formulate the personalized pain management schemes according to the physiological and biochemical parameters of each patient, and the pain management schemes are used for pain management. The personalized management mode can more effectively relieve the pain of the patient and improve the life quality of the patient.

Disclosed is a method for relieving cancer pain in a patient. The method comprises administering a patch to a patient in need thereof, wherein the patch comprises a backing layer and an adhesive layer laminated on the backing layer, the adhesive layer comprises an adhesive base and 150 mg to 225 mg of diclofenac sodium, and wherein the patch is applied once a day.

The invention discloses an RVG29 modified ziconotide loaded liposome as well as a preparation method and application thereof. The nano-liposome is prepared from phosphatidylpolyethylene glycol-RVG29, lecithin, cholesterol, phosphatidic acid and ziconotide. The preparation method comprises the following steps: performing repeated washing, resin detection and condensation operation on 2-chlorotrityl chloride resin and the like to prepare RVG29 resin, performing cutting sedimentation treatment and high performance liquid chromatography purification on the RVG29 resin by using phospholipid-polyethylene glycol-active ester and a cutting reagent, and adding lecithin, cholesterol, phosphatidic acid and ziconotide to synthesize and prepare the product liposome. The nano-liposome is a novel nano-liposome for the nose and the brain, gel adhesion and drug delivery are improved, the surface of the liposome targets a nicotinic acetylcholine receptor on the surface of a neuron, accurate drug delivery is achieved, no small-molecule cytotoxic drugs participate in the nano-liposome, the treatment compliance of cancer pain patients is improved, and the nano-liposome is a novel nano-liposome for the nose and the brain. The treatment effect and the life quality are improved.

This invention relates to the field of medical and health information technology and discloses a home-based pain monitoring system for malignant tumor patients. The invention collects various data related to home care of malignant tumor patients, forming pain datasets, medication datasets, and vital sign datasets. Based on these three datasets, pain risk indices, medication risk indices, and vital sign risk indices are obtained. These are then weighted and summed to obtain a comprehensive risk index. Effective correlation and collaborative analysis of multi-dimensional data improve the accuracy of the comprehensive risk index. The system determines whether to issue an alert based on the comprehensive risk index. If the comprehensive risk index reaches a threshold, three different levels of alerts (red, orange, and yellow) are issued and sent to both the patient-side interaction module and the medical staff-side interaction module. Upon receiving the alert, medical staff immediately review the patient's current condition report, analyze it, and receive timely improvement suggestions to help the patient improve their current condition, thus improving the efficiency of home care.

The invention belongs to the technical field of medicine, and particularly relates to application of LXH-2103 in preparation of medicine for treating pain and medicine dependence and a medicine composition of the LXH-2103. According to the application of the LXH-2103 disclosed by the invention in pain, the pain is acute incision pain, osteoarthritis pain, sciatica and cancer pain. The intravenous injection dosage of the medicine in an acute incision pain model animal is 7.5-20 mg / kg, and the oral administration dosage of the medicine in gavage is 20 mg / kg. The injection dosage of the medicine for treating osteoarthritis pain and sciatica is 2.5-7.5 mg / kg, and the oral administration dosage of the medicine for gavage is 20 mg / kg. The injection dosage of the medicine for cancer pain is 3-12 mg / kg, and the oral administration dosage of the medicine for gavage is 30 mg / kg. According to the establishment of the LXH-2103 in the pain model and the application of the LXH-2103 in the pain, a plurality of pain animal models are established, and the application of the LXH-2103 in the pain treatment is evaluated.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine plaster formula targeting tumor acupoints and application of the traditional Chinese medicine plaster formula, the traditional Chinese medicine plaster formula is composed of 24 traditional Chinese medicines such as musk, oldenlandia diffusa and sculellaria barbata, the scheme deeply integrates traditional Chinese medicine transdermal absorption and meridian targeting tropism mechanisms, and the limitation that traditional external treatment neglects overall differentiation is broken through. According to the preparation process, through segmented treatment and low-temperature reaction, the sensitization risk of minium is remarkably reduced, the anti-tumor curative effect can be synergistically enhanced, cancer pain can be relieved, malignant effusion can be controlled, particularly, the dosage of western medicines can be reduced and toxic and side effects can be reduced when the medicine is combined with radiotherapy and chemotherapy, and a safe and effective adjuvant therapy means is provided for tumor patients.

The application discloses a painkilling preparation containing radix scophulariae and radix aconiti and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. The preparation is a transdermal patch, which is composed of a backing layer, a drug depot layer and an anti-sticking layer. The drug depot layer contains traditional Chinese medicine active ingredients and patch auxiliaries such as pressure-sensitive adhesive and transdermal absorption accelerators. The traditional Chinese medicine active ingredients take radix scophulariae and radix aconiti as the core drug pair, and are supplemented with one or more of the following drugs: qi-regulating analgesic drugs, blood-removing qi-regulating drugs, blood-activating analgesic drugs, blood-stasis-removing analgesic drugs, warm-qi-activating cold-dispelling drugs, wind-dispelling cold-dispelling drugs and external analgesic drugs. The application is a modern traditional Chinese medicine external preparation prepared by a patch technology, and the drug can penetrate the skin and directly reach the lesion, thereby playing a therapeutic role on inflammatory pain, cancer pain and idiopathic pain. The preparation has the characteristics of large drug loading, good transdermal absorption, fast analgesic effect, long-acting effect and avoidance of oral toxicity risk.

The invention relates to the field of cancer pain analysis of human body images, in particular to a cancer pain treatment response evaluation method based on image analysis. The method comprises the steps of collecting continuous human body images of a patient; firstly, angular points in each image are collected; obtaining an angular point aggregation coefficient according to the distance characteristics between the angular points; uniformly dividing the image to obtain human body image layers; in the layering process, key angular points are obtained according to the angular point aggregation coefficient difference of the angular points; obtaining an activity coefficient according to similar features between the angular point aggregation coefficient difference and the key angular points; obtaining a response degree according to the activity coefficient; and performing response evaluation on cancer pain treatment according to the response degree of the patient. According to the invention, a non-invasive, real-time and quantitative cancer pain treatment dynamic evaluation method can be provided for the patient by dynamically tracking the activity characteristics of the patient.

The invention discloses a cancer pain patient intelligent portraying and accurate follow-up visit system based on a dynamic knowledge graph, and belongs to the technical field of medical informatization, artificial intelligence, knowledge graphs and accurate medical crossing, and the method comprises the following steps: 1, constructing a double-knowledge graph architecture comprising a medical knowledge graph and a follow-up visit question knowledge graph, wherein the medical knowledge graph covers entities such as cancer pain related diseases, drugs, symptoms and treatment schemes and association relationships, and a mapping relationship between questions and medical entities is established by the follow-up question knowledge graph; 2, accessing HIS / LIS system data, wearable device monitoring data, follow-up feedback data and other multi-source heterogeneous data, and performing cleaning, standardization and desensitization processing to complete multi-source data fusion; and 3, constructing a patient intelligent portrait containing six dimensions of pathology, pain, treatment, psychology, society and dynamic characteristics based on the fusion data, and storing and supporting real-time dynamic updating in a JSON format.

The invention provides a new application of the polyphyllin VII, the polyphyllin VII can obviously inhibit the growth of tumor cells and effectively reduce the pain caused by tumor overgrowth, and by utilizing the effect of the polyphyllin VII for simultaneously inhibiting tumor growth and relieving cancer pain, and by virtue of the synergistic regulation of the polyphyllin VII on a'tumor immune microenvironment-inflammation-pain 'axis, the tumor immune microenvironment-inflammation-pain' axis can be inhibited, so that the tumor immune microenvironment-inflammation-pain pain can be inhibited, and the tumor immune microenvironment-inflammation-pain pain can be inhibited. The double effects of anti-tumor curative effect and cancer pain relieving are achieved, continuous treatment can relieve cancer pain and inhibit tumor growth, an effective scheme is provided for improving the life quality and autonomous activity of cancer patients, and important clinical significance and value are achieved.

The invention discloses a portable cancer pain relieving massage device, and particularly relates to the technical field of massage equipment, the portable cancer pain relieving massage device comprises a massage device body for relieving cancer pain, a storage assembly and a rotating assembly; the massage device body comprises a supporting seat, a handle and massage beads for massaging limbs of a patient; the handle is fixedly arranged on one side of the supporting seat; the plurality of massage beads are connected with the supporting seat through the storage assembly; the storage assembly comprises a containing groove, a folding base and a containing groove used for containing limbs of a patient. An accommodating groove is formed in the other side of the supporting seat; the folding base is rotationally connected with the containing groove through a rotating assembly. A placement groove is formed in the side, close to the containing groove, of the folding seat, and the multiple massage beads are arranged in the placement groove; according to the invention, the structural design is reasonable, and the folding seat is folded and hidden in the accommodating groove, so that not only is the carrying convenient, but also the occupied space when the folding seat is not used is reduced.

The invention discloses an intelligent acupuncture analgesia system based on bio-electricity signal feedback and a method for treating cancer pain, and relates to the technical field of intelligent medical equipment, the system comprises a bio-electricity signal acquisition and processing module, a central processing module, an intelligent acupuncture module and an electrical stimulation modulation module; an individual pain baseline model is constructed through multi-mode bio-electricity signal collection and feature extraction, pain assessment is spanned from subjectivity to objectivity, the intelligent acupuncture module fuses visual positioning and pressure sensing, gas obtaining state judgment is quantified into a force signal mode, the problem of experience dependence of a traditional acupuncture analgesia technology is solved, and the pain assessment accuracy is improved. In addition, fuzzy PID control is adopted in closed-loop feedback, electrical stimulation parameters are dynamically adjusted, intelligent regulation and control of one person with one regulation are achieved, meanwhile, an initial acupoint library is matched in combination with traditional Chinese medicine differentiation and cancer pain types, individuation of an analgesia scheme is improved, the analgesia effective rate is remarkably improved, the operation error is reduced to the millimeter level, and safety and repeatability are remarkably improved.

The present application relates to the technical field of pain assessment, in particular to a tumor peace therapy pain grading assessment method based on multi-modal sensing, comprising the following steps: acquiring angular velocity and displacement direction to determine the static state, combining facial and voice features to locate the restricted period, extracting rhythm signals to identify the contradictory state, comparing the label content to extract the uncovered information, analyzing the signal features to divide the dominant channel, and modifying the label to obtain the pain grading verification label. In the present application, a static state recognition mechanism is established by fusing posture changes and signal fluctuation features, the behavior restricted time window is located by combining facial and voice features, the rhythm fluctuation information not covered by the label under the silent state is screened, the dominant channel path is constructed by extracting the signal fluctuation quantity, response sequence and synchronization relationship, the label content is compared and modified, the recognition range of the pain grading for non-extrinsic reaction state is expanded, and the coverage ability and resolution level of the label content for the rhythm behavior state are improved.

The invention relates to the field of food science and engineering, in particular to a functional food for relieving cancer pain, which is prepared by selecting traditional Chinese medicines for compatibility according to the principles of eliminating blood stasis, eliminating stagnation, dredging qi, inhibiting tumors and boosting and easing pain. The traditional Chinese medicinal materials with good detumescence, stagnation eliminating, stasis dispersing and relieving effects are used, so that tumors and tissues which are inflamed, swollen and blocked due to tumor infiltration, extrusion and damage are gradually decomposed and reduced, and pain is relieved; meanwhile, the living environment of tumor lesion tissues is improved, and tumor development is controlled and relieved; the viability of nervous system cells is improved by applying traditional Chinese medicines for soothing nerves and stabilizing qi; the traditional Chinese medicines for soothing liver and activating collaterals are used to enhance the resistance of nervous system, enhance the body metabolism function and reduce the injury caused by tumors. The medicines are used together to remove stasis, dissipate stagnation, reduce phlegm, remove stasis, activate blood, relieve pain, soothe the liver and calm the nerves, so that the aim of relieving pain is fulfilled.

1. Name of the design product: score board (cancer pain). 2. Use of the design product: used as a board for scoring the pain level of cancer patients, so as to facilitate medical staff to master the pain condition of cancer patients. 3. Design points of the design product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.

The application belongs to the field of pharmaceutical chemistry, and particularly relates to a Tropomyosin Receptor Kinase A (TrkA) inhibitor and a preparation method and application thereof, a structural formula of which is shown as formula (I); the compound provided by the application has high inhibitory activity on TrkA and good subtype selectivity. The compound has potential application in analgesic treatment, including but not limited to chronic pain caused by osteoarthritis, cancer pain, back pain and the like; the compound also has potential anticancer activity.

Provided in the present application are a phenylacrylamide compound, and a preparation method therefor and the use thereof. The phenylacrylamide compound has a structure represented by formula I. The phenylacrylamide compound provided in the present application can exhibit good binding to a plurality of target proteins, particularly exhibiting a good inhibitory activity against ACAT1 and 3-KAT targets, and has good bioavailability. The compound can be used in the preparation of a drug for preventing or treating tumors, cancer pain, radiotherapy- and chemotherapy-induced injuries, autoimmune diseases, infections, drug-induced myocarditis, cytokine storms, ischemic heart disease, inflammatory diseases and neurodegenerative diseases, or for anti-aging.

The utility model relates to a massage device for relieving cancer pain. The massage device comprises supports symmetrically arranged on the two sides of a sickbed. A mounting plate is arranged on the two supports through a lifting device, a lead screw and a servo motor are arranged on the bottom face of the mounting plate in the width direction of the sickbed, and the output end of the servo motor is connected to one end of the lead screw; a threaded sliding block is assembled on the lead screw, a massage box is fixedly installed on the bottom face of the threaded sliding block, and the servo motor controls the massage box to move in the width direction of the sickbed. The massage device can be kept at the position, needing to be massaged, of a patient without being held by hands, the labor intensity of medical workers can be effectively reduced, and the working efficiency of the medical workers is improved.

The invention discloses cancerous pain nursing equipment for old people. The cancerous pain nursing equipment comprises a cold compress belt, the pillow block is located below the cold compress belt, and a lifting mechanism is arranged at the bottom of the pillow block; the dragging mechanism is used for driving the cold compress belt to reciprocate left and right above the pillow block; the circulating water cooling mechanism is connected with a pipe fitting arranged in the cold compress belt, and the circulating water cooling mechanism is further connected with a cold water tank; a sliding groove is formed in the pillow block, the wiping strip is installed in the sliding groove, the bottom of the wiping strip is connected with an ejection mechanism, and the wiping strip is connected with an essential oil spraying mechanism. Cold water is circularly and continuously provided for the cold compress belt through the circulating water cooling mechanism, continuous low temperature of the cold compress belt is kept, the cold compress effect is improved, an affected part can be massaged while cold compress is conducted, and the pain relieving and nursing effect is improved.