15 results about "Tumor pain" patented technology

Provided is a use of an oncolytic virus in the treatment of pain, especially in the treatment of cancer while relieving cancer pain. The drug effect time of the oncolytic virus for relieving cancer pain is obviously longer than that of the existing opioid analgesic, and the dual effects of treating cancer and easing pain are achieved at the same time.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

The application discloses a polypeptide targeting palmitoylation modification of APLNR protein and application thereof in cancer pain treatment, in particular, application of APLNR protein and a palmitoylation modification site of the APLNR protein in relieving morphine tolerance in treatment of cancer pain. It is found by the application that the palmitoylation modification of APLNR is one of important response factors of neuropathic cancer pain, and a polypeptide targeting palmitoylation modification of APLNR protein is developed by taking the APLNR protein as a target, and the polypeptide is combined with morphine to treat cancer pain, so that the cancer pain can be effectively reduced, and the occurrence of morphine tolerance can be relieved, thereby providing a new strategy for clinical treatment of cancer pain and relief of morphine tolerance.

The invention provides a tumor pain management system based on an artificial intelligence technology, and relates to the technical field of medical auxiliary management systems, and the system comprises a biosensing module which is used for real-time physiological and biochemical monitoring; the AI analysis module is used for analyzing the data of the biosensing module and providing analysis data; the personalized pain management module is used for performing terminal control on the analysis data of the AI analysis module; the doctor / patient interface is used for terminal control of doctors / patients; the data storage module is used for storing physiological and biochemical parameters, analysis results and pain management schemes of patients, and through cooperative work of the AI analysis module and the personalized pain management module, the system can formulate the personalized pain management schemes according to the physiological and biochemical parameters of each patient, and the pain management schemes are used for pain management. The personalized management mode can more effectively relieve the pain of the patient and improve the life quality of the patient.

This invention relates to the field of medical and health information technology and discloses a home-based pain monitoring system for malignant tumor patients. The invention collects various data related to home care of malignant tumor patients, forming pain datasets, medication datasets, and vital sign datasets. Based on these three datasets, pain risk indices, medication risk indices, and vital sign risk indices are obtained. These are then weighted and summed to obtain a comprehensive risk index. Effective correlation and collaborative analysis of multi-dimensional data improve the accuracy of the comprehensive risk index. The system determines whether to issue an alert based on the comprehensive risk index. If the comprehensive risk index reaches a threshold, three different levels of alerts (red, orange, and yellow) are issued and sent to both the patient-side interaction module and the medical staff-side interaction module. Upon receiving the alert, medical staff immediately review the patient's current condition report, analyze it, and receive timely improvement suggestions to help the patient improve their current condition, thus improving the efficiency of home care.

The application discloses a painkilling preparation containing radix scophulariae and radix aconiti and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. The preparation is a transdermal patch, which is composed of a backing layer, a drug depot layer and an anti-sticking layer. The drug depot layer contains traditional Chinese medicine active ingredients and patch auxiliaries such as pressure-sensitive adhesive and transdermal absorption accelerators. The traditional Chinese medicine active ingredients take radix scophulariae and radix aconiti as the core drug pair, and are supplemented with one or more of the following drugs: qi-regulating analgesic drugs, blood-removing qi-regulating drugs, blood-activating analgesic drugs, blood-stasis-removing analgesic drugs, warm-qi-activating cold-dispelling drugs, wind-dispelling cold-dispelling drugs and external analgesic drugs. The application is a modern traditional Chinese medicine external preparation prepared by a patch technology, and the drug can penetrate the skin and directly reach the lesion, thereby playing a therapeutic role on inflammatory pain, cancer pain and idiopathic pain. The preparation has the characteristics of large drug loading, good transdermal absorption, fast analgesic effect, long-acting effect and avoidance of oral toxicity risk.

The invention discloses a cancer pain patient intelligent portraying and accurate follow-up visit system based on a dynamic knowledge graph, and belongs to the technical field of medical informatization, artificial intelligence, knowledge graphs and accurate medical crossing, and the method comprises the following steps: 1, constructing a double-knowledge graph architecture comprising a medical knowledge graph and a follow-up visit question knowledge graph, wherein the medical knowledge graph covers entities such as cancer pain related diseases, drugs, symptoms and treatment schemes and association relationships, and a mapping relationship between questions and medical entities is established by the follow-up question knowledge graph; 2, accessing HIS / LIS system data, wearable device monitoring data, follow-up feedback data and other multi-source heterogeneous data, and performing cleaning, standardization and desensitization processing to complete multi-source data fusion; and 3, constructing a patient intelligent portrait containing six dimensions of pathology, pain, treatment, psychology, society and dynamic characteristics based on the fusion data, and storing and supporting real-time dynamic updating in a JSON format.

The invention provides a new application of the polyphyllin VII, the polyphyllin VII can obviously inhibit the growth of tumor cells and effectively reduce the pain caused by tumor overgrowth, and by utilizing the effect of the polyphyllin VII for simultaneously inhibiting tumor growth and relieving cancer pain, and by virtue of the synergistic regulation of the polyphyllin VII on a'tumor immune microenvironment-inflammation-pain 'axis, the tumor immune microenvironment-inflammation-pain' axis can be inhibited, so that the tumor immune microenvironment-inflammation-pain pain can be inhibited, and the tumor immune microenvironment-inflammation-pain pain can be inhibited. The double effects of anti-tumor curative effect and cancer pain relieving are achieved, continuous treatment can relieve cancer pain and inhibit tumor growth, an effective scheme is provided for improving the life quality and autonomous activity of cancer patients, and important clinical significance and value are achieved.

The present application relates to the technical field of pain assessment, in particular to a tumor peace therapy pain grading assessment method based on multi-modal sensing, comprising the following steps: acquiring angular velocity and displacement direction to determine the static state, combining facial and voice features to locate the restricted period, extracting rhythm signals to identify the contradictory state, comparing the label content to extract the uncovered information, analyzing the signal features to divide the dominant channel, and modifying the label to obtain the pain grading verification label. In the present application, a static state recognition mechanism is established by fusing posture changes and signal fluctuation features, the behavior restricted time window is located by combining facial and voice features, the rhythm fluctuation information not covered by the label under the silent state is screened, the dominant channel path is constructed by extracting the signal fluctuation quantity, response sequence and synchronization relationship, the label content is compared and modified, the recognition range of the pain grading for non-extrinsic reaction state is expanded, and the coverage ability and resolution level of the label content for the rhythm behavior state are improved.

1. Name of the design product: score board (cancer pain). 2. Use of the design product: used as a board for scoring the pain level of cancer patients, so as to facilitate medical staff to master the pain condition of cancer patients. 3. Design points of the design product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.

The application belongs to the field of pharmaceutical chemistry, and particularly relates to a Tropomyosin Receptor Kinase A (TrkA) inhibitor and a preparation method and application thereof, a structural formula of which is shown as formula (I); the compound provided by the application has high inhibitory activity on TrkA and good subtype selectivity. The compound has potential application in analgesic treatment, including but not limited to chronic pain caused by osteoarthritis, cancer pain, back pain and the like; the compound also has potential anticancer activity.

Provided in the present application are a phenylacrylamide compound, and a preparation method therefor and the use thereof. The phenylacrylamide compound has a structure represented by formula I. The phenylacrylamide compound provided in the present application can exhibit good binding to a plurality of target proteins, particularly exhibiting a good inhibitory activity against ACAT1 and 3-KAT targets, and has good bioavailability. The compound can be used in the preparation of a drug for preventing or treating tumors, cancer pain, radiotherapy- and chemotherapy-induced injuries, autoimmune diseases, infections, drug-induced myocarditis, cytokine storms, ischemic heart disease, inflammatory diseases and neurodegenerative diseases, or for anti-aging.

The utility model relates to a massage device for relieving cancer pain. The massage device comprises supports symmetrically arranged on the two sides of a sickbed. A mounting plate is arranged on the two supports through a lifting device, a lead screw and a servo motor are arranged on the bottom face of the mounting plate in the width direction of the sickbed, and the output end of the servo motor is connected to one end of the lead screw; a threaded sliding block is assembled on the lead screw, a massage box is fixedly installed on the bottom face of the threaded sliding block, and the servo motor controls the massage box to move in the width direction of the sickbed. The massage device can be kept at the position, needing to be massaged, of a patient without being held by hands, the labor intensity of medical workers can be effectively reduced, and the working efficiency of the medical workers is improved.

The invention discloses cancerous pain nursing equipment for old people. The cancerous pain nursing equipment comprises a cold compress belt, the pillow block is located below the cold compress belt, and a lifting mechanism is arranged at the bottom of the pillow block; the dragging mechanism is used for driving the cold compress belt to reciprocate left and right above the pillow block; the circulating water cooling mechanism is connected with a pipe fitting arranged in the cold compress belt, and the circulating water cooling mechanism is further connected with a cold water tank; a sliding groove is formed in the pillow block, the wiping strip is installed in the sliding groove, the bottom of the wiping strip is connected with an ejection mechanism, and the wiping strip is connected with an essential oil spraying mechanism. Cold water is circularly and continuously provided for the cold compress belt through the circulating water cooling mechanism, continuous low temperature of the cold compress belt is kept, the cold compress effect is improved, an affected part can be massaged while cold compress is conducted, and the pain relieving and nursing effect is improved.

The present invention relates to improved method of treating breakthrough cancer pain. In particular the present invention relates to methods and devices for the treatment of breakthrough cancer pain through inhalation of tetrahydrocannabinol.