Use of reboxetine for the treatment of pain

Abstract

Use of (S,S)- or racemic reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of a pain condition selected from neuropathic pain, nociceptive pain, cancer pain, back pain, inflammatory pain, musculo-skeletal disorders, visceral pain, pain from strains / sprains, post-operative pain, posttraumatic pain, burns, renal colic, acute pain, central nervous system trauma, head pain, and orofacial pain, is disclosed. Use of (S,S)-reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of pain in a patient refractory to an alpha-2-delta ligand, and use of (S,S)- or racemic reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use as a mental performance or mood enhancer, are also disclosed.

Description

technical field [0001] The present invention relates to some novel uses of (S,S)- or racemic reboxetine for pain. Background technique [0002] US Patent 4,229,449 discloses the compound (RR,SS)-2-[α-(2-ethoxyphenoxy)benzyl]morpholine and pharmaceutically acceptable salts thereof, which have useful antidepressant effects. This compound is also known as racemic reboxetine. [0003] Many organic compounds exist in optically active forms, ie, they have the ability to rotate the plane of plane-polarized light. In describing optically active compounds, the prefixes R and S are used to denote the absolute configuration of the chiral center of the molecule. With respect to a particular chemical structure, each of a pair of enantiomers is identical except that they are a non-superimposable mirror image of the other. Specific stereoisomers may also be referred to as enantiomers, and a 1:1 mixture of these isomers is also often referred to as an enantiomeric or racemic mixture. ...

AI Technical Summary

Problems solved by technology

[0007] Reboxetine doesn't work like most antidepressants

Images