38 results about "Post-Procedural Pain" patented technology

The present invention provides capsaicinoid gel formulations and methods for relieving pre- and post-surgical pain at a site in a human or animal by administering at a surgical site in a human or animal in need thereof a dose of capsaicinoid gel in an amount effective to attenuate post-surgical pain at the surgical site, the dose of capsaicin ranging from 100 μg to 10,000 μg.

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and / or polynucleotides in the treatment and / or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

Disclosed are methods and devices for ultrasound-mediated non-invasive deep brain neuromodulation impacting one or a plurality of points in a neural circuit using intersecting ultrasound beams. Depending on the application, this can produce short-term effects (as in the treatment of post-surgical pain) or long-term effects in terms of Long-Term Potentiation (LTP) or Long-Term Depression (LTD) to treat indications such as neurologic and psychiatric conditions. Multiple beams intersect and summate at one or a plurality of targets. The ultrasound transducers are used with control of direction of the energy emission, intensity, frequency (carrier frequency and / or neuromodulation frequency), pulse duration, pulse pattern, and phase / intensity relationships to targeting and accomplishing up-regulation and / or down-regulation.

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and / or polynucleotides in the treatment and / or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

Disclosed are methods and devices for ultrasound-mediated non-invasive deep brain neuromodulation impacting one or a plurality of points in a neural circuit using patterned inputs. These are applicable whether the ultrasound beams intersect at the targets or not. Depending on the application, this can produce short-term effects (as in the treatment of post-surgical pain) or long-term effects in terms of Long-Term Potentiation (LTP) or Long-Term Depression (LTD) to treat indications such as neurologic and psychiatric conditions. The ultrasound transducers are used with control of frequency, firing pattern, and intensity to produce up-regulation or down-regulation.

The present invention discloses the preparation process and medicinal use of sulfonyl aniline derivatives as non-steroid antiphlogistic and analgetic compounds. These compounds have antiphlogistic and analgetic effects, so that they may be used in preparing medicine for clinically treating various inflammations, tumors, thrombotic angeitis, post-operation pain, menstrual pain, otorhinolaryngological diseases, wound pain, inflammation, etc.

Disclosed are devices for producing shaped or steered ultrasound for non-invasive deep brain or superficial neuromodulation impacting one or a plurality of points in a neural circuit. Depending on the application this can produce short-term effects (as in the treatment of post-surgical pain) or long-term effects in terms of Long-Term Potentiation (LTP) or Long-Term Depression (LTD) to treat indications such as neurologic and psychiatric conditions. The ultrasound transducers are used with control of direction of the energy emission, control of intensity, control of frequency for up-regulation or down-regulation, and control of phase / intensity relationships for focusing on neural targets.

The instant invention is directed towards an intra-operative method and kit for essentially eliminating pain associated with and resulting from surgical procedures, comprising the administration of a medical solution including a mixture of an injectable anesthetic, epinephrine, sodium chloride and an injectable anti-inflammatory agent to a plurality of sites within a surgical field utilizing a means for administration which, in a contemplated embodiment, may include a hollow shaft having a proximal end and a distal end, wherein upon administration, said medical solution flows within said shaft from said proximal end toward said distal end, which distal end is defined by a solid end having a plurality of circumferentially positioned apertures in said shaft for providing radially directed flow of the medicated solution circumferentially about said shaft.

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and / or polynucleotides in the treatment and / or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

Methods and compositions of treating a subject for post-surgical pain are provided. In the subject methods, a subject is treated for post-surgical pain by administering to the subject an effective amount of a narcotic emulsion, e.g., fentanyl emulsion, formulation. In certain embodiments, the emulsion formulations include a narcotic active agent, oil, water and an surfactant. Also provided are methods of making the subject emulsion formulations as well as kits that include the emulsion formulations.

The invention provides methods for preparing a benzo ring derivative with a benzylic quaternary carbon center and ethazocine hydrobromide. An aryl iodide and an alkylating agent as starting materialsare stirred for reaction in an organic solvent at 30 DEG C to 120 DEG C under the action of a palladium catalyst, a phosphine ligand, a norbornene derivative, and a base to obtain the benzo ring derivative with the benzylic quaternary carbon center. The raw materials used in the method are cheap and easy to obtain, reaction conditions are mild, substrate universality is good, yield is high, and the preparation process is simple. Meanwhile, the present invention also provides a method for synthesizing an ethazocine hydrobromide compound based on a 1,2,3,4-tetrahydronaphthalene compound having abenzylic all-carbon quaternary carbon center synthesized by the method, the drug ethazocine hydrobromide for treatment of cancer pain and post-operative pain can be synthesized only by four steps. The method has short synthetic steps, simple operation and high total yield.

Use of (S,S)- or racemic reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of a pain condition selected from neuropathic pain, nociceptive pain, cancer pain, back pain, inflammatory pain, musculo-skeletal disorders, visceral pain, pain from strains / sprains, post-operative pain, posttraumatic pain, burns, renal colic, acute pain, central nervous system trauma, head pain, and orofacial pain, is disclosed. Use of (S,S)-reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of pain in a patient refractory to an alpha-2-delta ligand, and use of (S,S)- or racemic reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use as a mental performance or mood enhancer, are also disclosed.

The present invention relates to delivery, including transdermal delivery, of a therapeutically effective amount of a compound useful for modulating gap junction formation and function, including an oligonucleotide for reducing gap junction formation and function, and methods and compositions for treating a subject suffering from pain associated with a disease, disorder or condition and associated with pain, including but not limited to muscle pain, ligament pain, tendon pain, joint pain and post-operative pain.

The invention provides an NGF (nerve growth factor) antibody as well as an antigen binding fragment and a medical application thereof and also provides a chimeric antibody, a humanized antibody and apH engineered antibody which contain antibody CDR areas, medical composition containing a human NGF antibody and an antigen binding fragment thereof as well as an application of the antibody in preparation of drugs for treating and / or preventing pains including postoperation pain, rheumatic arthritis pain and osteoarthritis pain.

The invention relates to an application of Arenaria brevipetala total saponin for preparing analgesics. Arenaria brevipetala total saponin is prepared into dosage forms, such as tablets, capsules, oral liquid, medicinal granules, injection and the like, for treating naturopathic pain, postoperative pain, cancer pain and psychogenic pain. Arenaria brevipetala total saponin has the functions of dispelling and relieving pains a patient suffers.

The invention discloses a BAPTA and an application of a derivant thereof, in particular to an application of the derivant in preparing analgesic drugs. Clinical indications include headache, prosopalgia, dysmenorrheal, postoperative pain, cancer pain, viscera pain, postherpetic neuralgia, phantom limb pain, HIV, pathologic pain related to multiple sclerosis, morphine class medicine tolerance or addiction patient pain and serious chronic intractable pain or usual clinical pain diseases.

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and / or polynucleotides in the treatment and / or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

The invention relates to a traditional Chinese medicine composition, and in particular relates to a compound pharmaceutical composition comprising a szechwan lovage rhizome extract and a caulis sinomenii extract, wherein the szechwan lovage rhizome extract is an extract containing more than 50% of ligustrazine, wherein the caulis sinomenii extract is an extract containing more than 50% of sinomenine; and the weight ratio of the szechwan lovage rhizome extract to the caulis sinomenii extract is (1-10):(1-10).

Use of a substance which is COX-2 selective and which can reduce prostaglandin levels of cerebrospinal fluid in a method for reducing the perception of pain in a subject is described. A preferred COX-2 selective inhibitor is nimesulide. Use of a COX-2 selective inhibitor as described has particular application in the relief of pain following surgery, especially following thoractotomy and also in the treatment of chronic post-thoracotomy pain.

Disclosed is a quick-acting pain-alleviating broad-spectrum compound formulation, which is prepared from cow-bezoar tablets, metronidazole, diclofenac sodium (diclofenac sodium), dexamethasone acetate and VB6.

Methods and compositions using a combination of adenosine monophosphate protein kinase (AMPK) activators for treating pain such as post-surgical pain or development of chronic pain. The two or more AMPK activators work synergistically and may be administered in individually sub-efficacious doses. The AMPK activators may have different mechanisms of AMPK activation. The AMPK activators may be administered systemically and / or topically in, for example, as a gel, ointment, cream, lotion, suspension, liquid, or transdermal patch.

The present invention relates to a preparation method of drain of biological plugging applied in the operation of repair rectocele and the application. The drain of biological plugging is made with human or animal skin tissue as the material, preparing in the procedures of fixing, cell extraction and coating with antibiotic layer; the drain is placed in the weak area of rectovaginal septa via operation, realizing the unstressing defect repair, eliminating the weak area and rebuilding the anterior wall of rectum. The present invention provides a biological scaffold for concrescence of repaired wound surface, remarkably advances the concrescence of wound surface and greatly shortens the concrescence time of wound surface as well as reduces the hospitalizing time; in addition, the drain of biological plugging of the present invention is coated with an antibiotic layer and has the drain effect, therefore, the infection of the wound surface is remarkably decreased; the efficiency of the drain of biological plugging of the present invention is 100 percent with a low recurrence rate. And the incident ratio of pains, fecal incontinence, stenosis of anal canal and other complicating diseases are reduced after the operation.

The invention consists of an electronic system for controlled and independent treatment of fractures, bone, muscle and tendon injuries, post-surgery pain and osteonecrosis, composed by a portable ultrasound generator, electronic prescription, centralised web services platform and computer program for ultrasonic treatment both within and outside the sanitary field, in the fields of human and veterinary medicine. The method controls the treatment applied, the charge prescribed by healthcare professionals by means of an electronic prescription, which can be administered by the patients themselves or by non-healthcare professionals independently, under the control of a computer program and a web platform used to activate the therapeutic equipment, write and delete the electronic prescription, transfer data stored in the therapeutic equipment to the web services platform to analyse the quantity and quality of the treatments, and update the program. Portable generator of ultrasonic pulses with set, unalterable parameters for the treatment of thorax, rib and sternum fractures, and of pain after thoracic surgery.

Methods of treating diabetic neuropathic pain and post-surgical pain are provided. The methods include administering to an individual a therapeutically effective amount of a compound of Formula I (Compound 1). The method can be used to treat diabetic neuropathy arising from any type of nerve damage, and can also be used to treat post-surgical pain arising from any surgical procedure without the side effects associated with widely used analgesics such as opioids. Compound 1 can be formulated into many suitable dosage forms, including oral dosage forms such as tablets.

The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and the use thereof. A compound represented by formula 1 according to the invention, or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof may be effectively used for the prevention or treatment of pain, for example, acute pain, chronic pain, neuropathic pain, post-surgery pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, or paroxysmal extreme pain disorder (PEPD).

The present invention relates to a compound having TrkA inhibitory activity and a pharmaceutical composition for preventing or treating pain containing the same as an active ingredient. The compound provided in one aspect of the present invention has excellent TrkA inhibitory activity and exhibits excellent pain inhibitory effects in an animal model of pain after a surgery, and thus can be effectively used as an analgesic.

The present invention relates to a compound of diclofenac-tramadol salt in 1:1 ratio and a pharmaceutical formulation comprising such compound. The present invention also relates to a method for treating a patient with moderate to moderately severe pain. The method comprises: identifying a patient suffering from moderate to moderately severe pain with pain intensity scale of 5-9, and administering to said patient the diclofenac-tramadol salt, in an effective amount. The method is particularly useful in treating postoperative pain after Cesarean, postoperative pain after non-Cesarean surgeries, cancer pain, osteoarthritis pain, or rheumatoid arthritis pain.

Provided is a nanobody or a multivalent nanobody that binds to a β-NGF antigen, which can be used for treating, preventing, detecting or diagnosing diseases associated with β-NGF, such as pain or inflammation, especially postoperative pain, rheumatoid arthritis Pain and Osteoarthritis Pain.