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A compound pharmaceutical composition composed of Chuanxiong extract and Qingfengteng extract

A composition and drug technology, applied in the direction of drug combination, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc., can solve the problems of unclear pathogenesis of neurogenic pain and lack of treatment methods

Active Publication Date: 2016-05-11
EXPERIMENTAL RES CENT CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the pathogenesis of neuropathic pain is not very clear, and there is a lack of satisfactory treatment methods in clinical practice.

Method used

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  • A compound pharmaceutical composition composed of Chuanxiong extract and Qingfengteng extract
  • A compound pharmaceutical composition composed of Chuanxiong extract and Qingfengteng extract
  • A compound pharmaceutical composition composed of Chuanxiong extract and Qingfengteng extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Preparation of Rhizoma Chuanxiong Extract

[0062] method 1

[0063] Chuanxiong sliced ​​and soaked in ethanol for 8-48 hours, slice thickness 1-5mm. The powdery crude extract of Chuanxiong was obtained by ethanol extraction. The crude extract of Ligusticum chuanxiong is subjected to CO2 supercritical extraction to obtain the total alkaloids of Ligusticum chuanxiong in brown oily form. The extraction temperature is 55°C±5°C, the pressure is 5-8Mpa, and the time is 0.5-1 hour.

[0064] Method 2

[0065] Take the rhizome powder of Rhizoma Chuanxiong, add ethanol to reflux to extract, combine the extracts, concentrate under reduced pressure to 1 times the volume of the medicinal materials, refrigerate, filter, add ether to the filtrate, extract the ether phase with sulfuric acid, adjust the pH of the water layer to 9-10, and extract with chloroform , the chloroform layer recovered the solvent, added sulfuric acid to dissolve, filtered, added an equal amount of chlorofor...

Embodiment 2

[0074] Preparation of Capsule Compositions

[0075] Take Chuanxiong extract and Qingfengteng extract with a weight ratio of 2.5 to 1, pulverize, pass through a 100-mesh sieve, add appropriate amount of dextrin and starch, mix well, make soft material, granulate, dry, and pack into capsules.

Embodiment 3

[0077] Preparation of Granular Compositions

[0078] Take Chuanxiong extract and Qingfengteng extract with a weight ratio of 2 to 1, pulverize, pass through a 100-mesh sieve, add appropriate amount of dextrin and sucrose, mix well, make soft material, granulate, dry, and pack.

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Abstract

The invention relates to a traditional Chinese medicine composition, and in particular relates to a compound pharmaceutical composition comprising a szechwan lovage rhizome extract and a caulis sinomenii extract, wherein the szechwan lovage rhizome extract is an extract containing more than 50% of ligustrazine, wherein the caulis sinomenii extract is an extract containing more than 50% of sinomenine; and the weight ratio of the szechwan lovage rhizome extract to the caulis sinomenii extract is (1-10):(1-10).

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine composition, in particular to a compound medicine composition composed of Chuanxiong extract and Qingfengteng extract. Background technique: [0002] Ligusticum chuanxiong, aliases: Shanjuqiong, xiongxiang, Xiangguo, Huxiang, Maxian, xiongxiang, quenaoxiong, Jingxiong, Guanxiong, Fuxiong, Taixiong, Xixiong, are the rhizomes of the Umbelliferae plant Chuanxiong . Its chemical components include: chuanxiongzine, ryegrassine or perlolyrine, ligustilide, wallichilide, vanillic acid, caffeic acid , protocatechuic acid (protocatechuic acid) [9], ferulic acid (ferulic acid), chrysophanol (chrysophanic acid), sedanonic acid (sedanonic acid), L-isoleucyl-L-valine anhydride (L-isoleucyl- L-valineanhydride), L-valyl-L-valineanhydride (L-valyl-L-valincachydride), ryegrass base (perlolyrine), ligustruol, uracil (uracil), trimethylamine hydrochloride (trimethylamine-HCL) , choline chloride (chloinechloride)...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4965A61K31/485A61K36/59A61P29/00
Inventor 王丹巧李连达赵小亮张美玉刘洋
Owner EXPERIMENTAL RES CENT CHINA ACAD OF CHINESE MEDICAL SCI
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