8 results about "Chrysophanic acid" patented technology

The invention discloses preparation and application of a nano enzyme. The preparation method of the nano enzyme comprises the following steps: dissolving copper salt and hydroxy anthraquinone carboxylic acid in water to obtain a first solution; adjusting the pH of the first solution to be alkaline, and heating for reaction to obtain a product solution; and centrifuging the product solution, taking the precipitate, washing and drying to obtain the Cu nano-enzyme. The copper salt comprises at least one of copper sulfate, copper chloride, copper nitrate and copper hydroxide; the hydroxy anthraquinone carboxylic acid is rhein. According to the invention, Cu is used as a transition metal source and reacts with specific hydroxy anthraquinone carboxylic acid to prepare the Cu nano-enzyme (Cu-Rhein) with excellent peroxidase-like activity. The Cu nano enzyme can be applied to promotion of hydrogen peroxide oxidation TMB color development and detection of penicillamine, the accuracy of penicillamine detection is high, and the Cu nano enzyme has good application prospects.

The invention provides a rheum officinale active ingredient composition as well as a preparation method and application thereof, and the active ingredients of the composition consist of emodin methyl ether glycoside, rhein, rhein, gallic acid, emodin and chrysophanol glycoside. The weight ratio of physcion glycoside to rhein glycoside to rhein to gallic acid to emodin to chrysophanol glycoside is 200: 100: 20: 10: 1: 1, the composition is prepared in a monomer mixing mode, the pancreatitis focus area is remarkably reduced, the pathological score is remarkably improved, and the serum amylase and lipase level is remarkably reduced; a certain liver protection effect is achieved; the components are clear in material basis, have no obvious liver and kidney toxicity, and can obviously improve and treat pancreatitis.

This application discloses an intramolecular hydrogen bond-enhanced anthraquinone derivative, its synthesis method, and its application, relating to the field of electrochemical energy storage. The acetic acid-modified anthraquinone RH-DA or AE-DA is 2,2'-(3-carboxyl-1,8-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2,7-diyl)diacetic acid and 2,2'-(1,8-dihydroxy-3-(hydroxymethyl)-9,10-dioxo-9,10-dihydroanthracene-2,7-diyl)diacetic acid. Rhein or aloe-emodin is dissolved in NaOH, glyoxylic acid solution and sodium dithionite are added, and after stirring, sodium dithionite is added again. After stirring and cooling to room temperature, hydrogen peroxide solution and HCl solution are added, causing precipitation. After washing with HCl, the precipitate is dried in a vacuum drying oven to obtain a black-green solid RH-DA or a yellow-green solid AE-DA. Its application in alkaline aqueous organic flow batteries is also disclosed.

The application discloses a method for establishing HPLC fingerprint spectrum of Lianhuaqingwen capsules based on chemical identification method, and is characterized in that the method adopts high performance liquid chromatography and specifically comprises the following steps: 1) preparation of reference solution: precisely take new chlorogenic acid, quercitrin, forsythia glycoside, amygdalin, emodin, chrysophanol, chlorogenic acid, forsythia glycoside A, rhein, glycyrrhizic acid reference, and add methanol to prepare a reference solution; 2) preparation of test sample solution: 3) chromatographic conditions: the mobile phase is 0.1% phosphoric acid aqueous solution (A)-acetonitrile (B), gradient elution; the detection wavelength is 207 nm, the column temperature is 30 DEG C, and the flow rate is 1.0 mL·min ‑1 ; 4) determination: precisely take the test sample solution and inject it into a high performance liquid chromatograph, and the HPLC fingerprint spectrum is obtained by HPLC determination. The HPLC fingerprint spectrum established by the application is helpful for further improving the quality evaluation system of Lianhuaqingwen capsules and can provide a reference for the quality control of Lianhuaqingwen capsules.

A fructus cannabis intestine-moistening pill high performance liquid chromatography fingerprint establishment method relates to the field of medicine, and comprises the following steps: weighing fructus cannabis intestine-moistening pill medicinal material powder, adding methanol, plugging, weighing, soaking, carrying out ultrasonic extraction, cooling, weighing, complementing the weight loss, uniformly shaking, and filtering to obtain a test solution; the method comprises the following steps: weighing an emodin reference substance, a rhein reference substance, a chrysophanol reference substance, a hesperidin reference substance, a costunolide reference substance, a dehydrocostunolide reference substance and a paeoniflorin reference substance, adding methanol to prepare a mixed reference substance solution, and filtering to obtain a reference substance solution; sucking the test sample solution and the reference substance solution, injecting the test sample solution and the reference substance solution into a high performance liquid chromatograph, measuring and recording a chromatogram, importing detection results of the test sample solution and the reference substance solution into fingerprint spectrum software, and generating a reference fingerprint spectrum through data matching. The quality of the fructus cannabis intestine moistening pill can be effectively represented, the quality of the medicine can be comprehensively monitored, and the method has the advantages of being high in stability, high in precision and good in reproducibility.

The present application belongs to the technical field of industrial analysis and detection, and provides a chrysophanol-based natural perfume reconstituted molecular tool, a preparation method and application thereof. The method comprises the following steps: mixing a natural perfume solution and a chrysophanol solution to perform a dehydration condensation reaction, and obtaining the chrysophanol-based natural perfume reconstituted molecular tool. The raw material is abundant and belongs to a natural plant extract, the cost is low, the reagent required in the whole process is single, is non-toxic and harmless, and the final yield is also high. The obtained molecular tool has a stable chemical structure, can exist in a complex wax emulsion for a long time, has stable light signal release performance, can effectively release a light signal in a wax emulsion with various pH values, can maintain good light signal output in a long-term irradiation process, has a high viscosity sensitivity coefficient, and has a detection lower limit of viscosity as low as 1.23 cP, is suitable for measuring wax emulsion micro-area viscosity changes, and is helpful to realize rapid, efficient and visual preparation of wax emulsion consistency.

The present application relates to the technical field of medical polymer materials, and particularly relates to a drug mineralized microstick, a preparation method and application thereof. The preparation method of the drug mineralized microstick provided by the present application comprises the following steps: A) mixing rhubarb acid and alkali liquor to obtain a first solution; B) mixing the first solution with a degradable high polymer compound to obtain a second solution; the degradable high polymer compound contains carboxylate; C) mixing the second solution with a metal salt solution to obtain a third solution; D) incubating the third solution under constant temperature and humidity to obtain the drug mineralized microstick. The drug mineralized microstick prepared by the present application has a highly crystalline structure and the ability to effectively release small molecule drugs; the drug mineralized microstick has the characteristics of low hemolysis and low cytotoxicity; in an environment of excessive inflammatory response, the drug mineralized microstick can effectively reduce the expression of proinflammatory mediators, and exhibits high anti-inflammatory activity.

The present application belongs to the field of medicine, and particularly relates to a quality detection method of a Shengqing Jiangsuan mixture. The present application firstly establishes a characteristic spectrum method for simultaneously detecting 10 main active components (paeoniflorin, puerarin, gentiopicroside, loganin acid, astilbin, benzoylpaeoniflorin, resveratrol, rhein, pachymaran A and pachymaran B) in the mixture, overcomes the limitation of single component control quality, and can more comprehensively and objectively evaluate the overall quality of the medicine. Through optimizing the sample pretreatment process and the chromatographic gradient elution conditions, the present application effectively eliminates the interference of the complex matrix, and ensures the good separation of each component. The method has strong specificity, no interference of negative, and can accurately identify the target component.