Sufonic aniline derivatives and their medicinal use
A drug and compound technology, applied in the field of sulfonyl anilide derivatives, can solve problems such as liver toxicity
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0020] The preparation of embodiment 1 compound
[0021] A: Preparation of trans-4-methyl-cyclohexylamine salt of 4-nitro-2-phenoxymethanesulfonanilide
[0022] Dissolve 6.17 g of 4-nitro-2-phenoxy-methanesulfonanilide in 25 ml of acetone, add 2.37 g of trans-4-methyl-cyclohexylamine dropwise under stirring at room temperature, and heat for 1 hour , part of the solvent was removed under reduced pressure, and the residue was left overnight, and bright yellow needle-like crystals were precipitated, which were collected by filtration. Recrystallized from ethanol to obtain 6.54 g of trans-4-methyl-cyclohexylamine salt of 4-nitro-2-phenoxy-methanesulfonanilide (yield 77.6%), melting point 149-151°C.
[0023] Molecular formula C 20 h 27 N 3 o 5 S molecular weight 421.51
[0024] Elemental analysis: theoretical value C 56.99%, H 6.46%, N 9.97%
[0025] Experimental value C 57.00%, H 6.49%, N 9.92%
[0026] B: Preparation of 4-nitro-2-(4′-methoxy-phenoxy)-methanesulf...
Embodiment 2
[0040] Example 2 Biological Evaluation
[0041] In the following biological experiments, the effects of each compound on mouse acetic acid writhing analgesic response and anti-mouse carrageenan foot inflammation were mainly observed. Nimesulide was used as a positive control drug to conduct a preliminary study on its therapeutic effect. evaluate. The results are shown in the table below:
[0042] Table 1 The effect of oral nimesulide and its derivatives on antagonizing the writhing response of mice with acetic acid
[0043] Drug Dose Number of animals Number of writhes
[0044] Mm / kg (M±SD)
[0045] DMSO control 14 32.4±24.1
[0046] Nimesulide 0.32 9 22.0±1 6.9
[0047]0.97 9 14.7±11.3*
[0048] S 1 0.97 10 11.7±14.2*
[0049] S 2 0.32 10 20.6±18.8
[0050] S 3 0.97 10 5.3±6.4**#
[0051] S 5 0.97 10 34.5±16.2
[0052] Compared with DMSO control, *P<0.05 **P<0.01
[0053] Compared with Nimesuli, #P<0.05
[0054] ...
PUM
Property | Measurement | Unit |
---|---|---|
melting point | aaaaa | aaaaa |
melting point | aaaaa | aaaaa |
melting point | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com