52 results about "Oa osteoarthritis" patented technology

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and / or polynucleotides in the treatment and / or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and / or polynucleotides in the treatment and / or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

A method for treating a patient suffering from osteoarthritis and an internal brace for distraction arthroplasty including femoral and tibial components which can be fixed to a patient's femur and tibia and which in combination distract or separate the knee joint without substantially hindering mobility of the knee.

The present invention provides compositions comprising hyaluronan with high elasticity, as well as methods for improving joint function, reducing pain associated with joint function and treating osteoarthritis by introducing into a joint a therapeutically effective amount of a composition comprising hyaluronan with high elasticity.

The invention provides a traditional Chinese medicine composition for treating osteoarthritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from from the following raw material medicines in parts by weight: 10-20 parts of poria cocos, 5-15 parts of cassia twigs, 2-8 parts of rhizoma atractylodis, 2-8 parts of cortex phellodendri, 2-8 parts of radix stephaniae tetrandrae, 2-8 parts of polyporus umbellatus, 2-8 parts of rhizoma drynariae, 5-15 parts of rhizoma corydalis and 3-9 parts of radix cyathulae. The composition disclosed by the invention has the functions of tonifying spleen, promoting diuresis, dispelling wind, clearing heat, dredging collaterals and relieving pain, and is clinically applicable to patients suffering from rheumatic fever arthralgia in the attack stage of knee osteoarthritis, wherein the patients have the symptoms of swelling, pain, unfavorable flexion and extension and even local pyrexia, redness and swelling of joints, fat and big tongue body with tooth prints, yellow and greasy tongue coating and few pulse strings. When the composition provided by the invention is used for intervening in a rabbit with knee osteoarthritis, results show that the composition can relieve symptoms like joint swelling and skin temperature rise of the rabbit with knee osteoarthritis, improve joint functions, reduce the contents of IL-1[beta], TNF[alpha], PGE2 and NO in joints, relieve synovitis and delay the progress of knee osteoarthritis. Clinical observation results show that the composition provided by the invention has theeffects of relieving swelling and pain and improving joint functions for patients with knee osteoarthritis.

The present invention provides compositions and methods for treating joint disorders that are characterized by an inflammatory component. In some aspects, the compositions and methods are to prevent the progression of osteoarthritis and other arthritides and to treat osteoarthritis and other arthritides in a mammalian joint.

The invention relates to the industries of functional food, cosmetics and medicine, and in particular, relates to glucosamine hyaluronate and an application thereof. The structural formula of the glucosamine hyaluronate is represented by a formula (1), and the average polymerization degree n is 10-1000. The prepared glucosamine hyaluronate has a good treatment effect on osteoarthritis model rats in an articular cavity injection mode, and can be used for but not limited to the field of daily chemicals especially moisture absorption and preservation agents of cosmetics, wrinkle removal filling injection for beauty, anti-fatigue eye drops and related joint treatment or auxiliary health care.

The invention discloses an externally-applied glucosamine chondroitin nano-preparation and a preparation method thereof. The externally-applied glucosamine chondroitin nano-preparation comprises a nano-liposome and an inner material, the inner material comprises the following components in percentage by mass: 4-6% of glycerol, 3-6% of propylene glycol, 5-12% of N-acetyl-D-glucosamine, 2-4% of a humectant, 8-10% of a penetration enhancer, 2-8% of shark bone chondroitin sulfate, 1-3% of bovine bone chondroitin, 8-12% of a lipid material, 2-6% of stearyl alcohol, 2-6% of cetyl alcohol, 8-10% of mineral oil, 2-4% of silicone oil, 2-4% of an emulsifier, 1.2-1.6% of a preservative and the balance of deionized water. The particle size is smaller, the transdermal rate is high, the usage amount of effective components is small, the production cost is saved, and glucosamine and chondroitin can rapidly permeate into joints to lubricate the joints, relieve osteoarthritis pain and inflammation and repair cartilage tissue.

Provided are liposomes that encapsulate adenosine. The liposomes may be formed from sphingomyelin or a combination of sphingomyelin and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) or a combination of sphingomyelin and 1,2-dimyristoyl-sn-glycero-3-phosphorylglycerol (DMPG) or a combination of sphingomyelin, DMPG, and DMPC. The liposomes encapsulating adenosine may be used to induce cartilage regeneration, treat osteoarthritis, alleviate joint pain, and / or slow, arrest, and / or reverse progressive structural tissue damage associated with osteoarthritis or treat osteoarthritis, rheumatoid arthritis, acute gouty arthritis, and / or synovitis. The liposomes may release adenosine for up to two weeks.

A diagnostic and a method of treatment are disclosed whereby the diagnostic identifies patients more likely to respond to a therapeutic intervention thereby improving clinical benefits including improved joint function, reduced pain, and other clinical symptoms.

The invention discloses an anti-inflammatory and analgesic traditional Chinese medicine composition and its preparation method and application. The anti-inflammatory and analgesic traditional Chinese medicine composition is made of active components alone or mixed with active components and common auxiliary materials for pharmaceutical preparations to form an external dosage form. The active ingredient is prepared from mugwort leaves, impatiens, prickly ash and black ants according to a certain weight percentage. The anti-inflammatory and analgesic traditional Chinese medicine composition of the present invention adopts pure natural traditional Chinese medicine as a raw material, has no side effects, is safe and reliable, has wide distribution of medicinal materials, simple preparation process, low price of extraction solvent, stable and controllable quality, and is easy to scale up. In addition, the traditional Chinese medicine composition provided by the present invention, after combining the four traditional Chinese medicines of Artemisia argyi, Impatiens, Zanthoxylum bungeanum and black ant, has played a synergistic effect, has obvious analgesic and anti-inflammatory effects on osteoarthritis, and can significantly improve osteoarthritis. Joint swelling and pain, poor flexion and extension and other lesions provide new options for clinical medication.

The present invention relates to a composition for improving the health status of various joints in the human body. The composition includes at least one plant extract as fatty base with active role, at least one extract from plants with anti-microbial properties, at least one extract from plants with analgesic and / or anti-inflammatory properties, and at least one extract from plants with anti-rheumatic and regenerative properties, to which dimethylsulfoxide, allantoin and / or potassium alum may be added. The composition may be used to treat osteoarthritis, rheumatic joint disease, joint swelling, pain, hallux valgus, traumatic conditions of the joints including sprains, strains, post-surgical recovery, bone edema, and speed up the recovery of athletes post-injury.