A traditional Chinese medicine preparation for treating osteopathia comprises two groups of composing prescriptions, namely, the first group is as follows: a medicinal plaster A is prepared by centipede, scorpion, bungarus parvus, zaocys dhumnade, lumbricus, pangolin scales, ground beeltle, honeybee, black ants, moschus and venenum bufonis; the second group is as follows: a medicinal plaster B is prepared by semen strychni, aconitum brachypodum, flos daturae, radix aconiti, cortex cinnamomi, radix aconiti carmichaeli, panax notoginseng, ligusticum chuanxiong, radix dipsaci, radix cyathulae, fructus psoraleae, borneol, rhizoma homalomenae, radix clematidis, herba ephedra, herba asari cum radice, rhizoma sparganii, rhizoma curcumae, angelica sinensis, flos carthami, radix angelicae pubescentis, honeycomb, cortex eucommiae and semen momordicae. The medicinal plaster A and the medicinal plaster B are alternately applied while the two plasters are utilized. The traditional Chinese medicine preparation can also be prepared into various doses of medicinal plasters, ointments and externally-applied medicinal oils, and can be brewed into the medicinal liquor after being slightly adjusted or decocted to a decoction for oral administration. The invention has the following beneficial effects: the traditional Chinese medicine preparation is utilized to treat the diseases, such as osteoproliferation, osteoarthritis and degenerative osteoarthritis, and has the characteristics of being remarkable in efficacy, stable in effect, long in storage period, unlikely to relapse, flexible to prepare, convenient to use and taking effect quickly.