31 results about "Degenerative osteoarthritis" patented technology

A traditional Chinese medicine preparation for treating osteopathia comprises two groups of composing prescriptions, namely, the first group is as follows: a medicinal plaster A is prepared by centipede, scorpion, bungarus parvus, zaocys dhumnade, lumbricus, pangolin scales, ground beeltle, honeybee, black ants, moschus and venenum bufonis; the second group is as follows: a medicinal plaster B is prepared by semen strychni, aconitum brachypodum, flos daturae, radix aconiti, cortex cinnamomi, radix aconiti carmichaeli, panax notoginseng, ligusticum chuanxiong, radix dipsaci, radix cyathulae, fructus psoraleae, borneol, rhizoma homalomenae, radix clematidis, herba ephedra, herba asari cum radice, rhizoma sparganii, rhizoma curcumae, angelica sinensis, flos carthami, radix angelicae pubescentis, honeycomb, cortex eucommiae and semen momordicae. The medicinal plaster A and the medicinal plaster B are alternately applied while the two plasters are utilized. The traditional Chinese medicine preparation can also be prepared into various doses of medicinal plasters, ointments and externally-applied medicinal oils, and can be brewed into the medicinal liquor after being slightly adjusted or decocted to a decoction for oral administration. The invention has the following beneficial effects: the traditional Chinese medicine preparation is utilized to treat the diseases, such as osteoproliferation, osteoarthritis and degenerative osteoarthritis, and has the characteristics of being remarkable in efficacy, stable in effect, long in storage period, unlikely to relapse, flexible to prepare, convenient to use and taking effect quickly.

The invention discloses a traditional Chinese medicine plaster for treating neck-shoulder and lumbocrural pain. The traditional Chinese medicine plaster is prepared from the following active pharmaceutical ingredients: radix angelicae lateralis preparata, radix paeoniae rubra, safflower, sangusis draconis, catechu, olibanum, myrrha, radix gentianae macrophyllae, semen strychni, radix saposhnikoviae and radix glycyrrhizae. The traditional Chinese medicine plaster is reasonable in formula, significant in efficacy, low in price, has a good effect on relieving pain caused by various reasons, is especially applicable to pain caused by cervical spondylosis, lumbar muscle degeneration, psoatic strain, rheumatism rheumatoid arthritis, uarthritis, joint sprains, degenerative osteoarthritis and the like, and has no obvious adverse effects.

The invention discloses medicinal liquor for strengthening bone and a preparation method thereof. The medicinal liquor for strengthening bone contains sheep tibia, sheep kidney, cinnamon, medlar, zaocys dhumnades and white spirit. The preparation method for the medicinal liquor for strengthening bone comprises the following steps of: adding cinnamon, medlar, and zaocys dhumnades into sheep tibia lyophilized powder and sheep kidney lyophilized powder, putting a mixture into a cloth bag, putting the cloth bag into a container, adding wine into the container, covering, and heating the container over fire for more than 10 minutes, keeping the container away from the fire, cooling, sealing for immersing for more than 3 days, and shaking everyday and filtering dregs out to obtain the medicinal liquor for strengthening bone. The medicinal liquor is convenient to prepare, stable in medicinal property, and safe and effective; the effect of the medicinal liquor is achieved through the mutual effect of the white spirit and medicines; the curative effect is improved; the medicinal liquor is used for treating wind-toxin and waist and knee weakness which are caused by liver-kidney deficiency, and exogenous and endogenous pathogenic factors, patients who suffer from pain, swelling, and stiffness of shoulders, backs and limbs and have symptoms of rheumatic arthritis, rheumatoid arthritis, and senile degenerative osteoarthritis or patients who suffer from arthralgia, swelling and stiffness after trauma and bone fracture; and the medicinal liquor for strengthening bone can address both the symptoms and root causes, and does not have toxic or side effects; and after the medicinal liquor for strengthening bone is taken by patients, disease relapse is prevented.

The invention relates to a pharmaceutical composition for treating bone diseases, an injection thereof and preparation methods thereof. The pharmaceutical composition is composed of an extraction liquid of pig four limbs and a melon seed extraction liquid. Further, the pharmaceutical composition is added with mixed extraction liquids respectively prepared from commen bomhax flower, flos buddlejae and herba eupatorii. The prepared pharmaceutical composition has substantially improved treatment effect on rheumatoid arthritis, degenerative osteoarthritis, ankylosing spondylitis, sciatica, lumbar disc herniation and other bone diseases, is improved in treatment effect on gout and has no toxic and side effects. Additionally, the provided injection has extremely high stability and is substantial in effect.

The invention discloses a compound termitarium and a preparation method thereof. The compound termitarium comprises the following raw material medicines: 10 to 15 parts of heracleum, 10 to 15 parts of salvia miltiorrhiza, 10 to 15 parts of achyranthes bidentata, 10 to 15 parts of rhizoma drynariae, 10 to 15 parts of caulis spatholobi and 5 to 10 parts of termitarium. The preparation method comprises the following steps of: extracting the termitarium with ethanol and filtering to obtain filtrate; decocting the medicinal dregs with water and filtering to obtain medicinal liquid; concentrating the medicinal liquid under reduced pressure to obtain termitarium extractum; mixing the heracleum, the salvia miltiorrhiza, the achyranthes bidentata, the rhizoma drynariae and the caulis spatholobi, extracting the mixture with ethanol and filtering to obtain filtrate; combining the filtrate and concentrating under reduced pressure to obtain extractum; and combining the extractum, drying under reduced pressure and crushing to obtain the medicinal powder. The compound termitarium and the preparation method thereof have the advantages of treating degenerative osteoarthritis safely and effectively, fundamentally helping the organism to recover to the normal state, conditioning the whole body, adjusting local parts and treating both the symptoms and root causes truly, along with low cost.

The invention relates to a pharmaceutical composition for treating osteoproliferation and process for preparation, wherein the medicinal composition comprises the following raw materials (by weight portion): Tripterygium wilfordii 50-350 parts, Chinese ephedra 50-350 parts, Chinese angelica root 50-350 parts, dried ginger 50-350 parts, root of Dahurain angelica 50-350 parts, futokadsura stem 50-350 parts, frank incense 50-350 parts, notoginseng 10-150 parts, curcuma longa 10-150 parts, pepper 10-150 parts, camphor 0-150 parts, oil of Chinese cinnamon 1-30 parts and menthol 0-150 parts.

The present invention relates to a composition for treating osteoarthritis and a method for preparing the same, and more specifically, relates to a composition comprising hydrophilized sulfasalazine as an active ingredient and hyaluronic acid so as to enable effective treatment of osteoarthritis such as degenerative osteoarthritis by preventing joint wear in addition to symptom relief through intraarticular or local administration, and a method for preparing the same. When such a composition for osteoarthritis treatment is prepared by the preparation method according to the present invention, the dissolved state is maintained beyond a neutralization step after dissolution, preventing precipitation of sulfalazine by salting out occurring after neutralization, and thus a composition comprising high concentration of sulfasalazine can be prepared, and the composition prepared accordingly is highly effective in treating osteoarthritis, particularly degenerative osteoarthritis, through the intraarticular or local administration, since it comprises high concentration of sulfasalazine which had to be formulated at low concentration by conventional method due to poor solubility.

Disclosed therein is a shoe having a functional sole for degenerative osteoarthritis of a knee joint, which includes a sole having at least one of an insole, a midsole and an outsole, characterized in that, in longitudinal section of the insole, the outsole or the midsole formed integrally with one of the insole and the outsole, both sides of an inner face and an outer face thereof are not parallel with each other, and that an angle of one of both sides of the inner face or the outer face to the ground outside the sole is smaller than an angle of the opposed side to the ground outside the sole.

The present invention discloses a medicine compound preparation for treating osteoarthritis. The compound preparation is preferably a compound injection and comprises a nerve guiding factor Sema and asodium hyaluronate injection. A concentration of the nerve guiding factor Sema in the sodium hyaluronate injection is 4-9 [mu]g/mL. In a preferred embodiment, the nerve guiding factor Sema is selected from Sema 3a protein. Results of clinical trials show that the injection prepared by combination of the nerve guiding factor Sema 3a protein and the sodium hyaluronate injection has a superior therapeutic effect for patients with early stage degenerative osteoarthritis than that of a sodium hyaluronate injection treatment alone.

The invention relates to a traditional Chinese medicine capsule for treating osteoporosis and degenerative osteoarthritis, which can efficiently solve the treatment problems of the osteoporosis and the degenerative osteoarthritis. The traditional Chinese medicine capsule is prepared form the following components in parts by weight: 3.25-3.75 parts of panax notoginseng, 1-1.5 parts of angelica sinensis, 0.5-1 part of achyranthes root, 1.25-1.75 parts of medlar, 0.5-1 part of barrenwort, 0.5-1 part of prepared oyster, 0.5-1 part of ligustrum lucidum, 1-1.5 parts of gynostemma pentaphylla, 0.5-1 part of donkey-hide gelatin, 0.5-1 part of prepared black bean and 0.5-1 part of glycyrrhiza, and the traditional Chinese medicine capsule is prepared by the steps of: firstly heating the panax notoginseng for 1h at the constant temperature of 110 DEG C to prepare into cooked panax notoginseng, taking out, drying and crushing into 120-mesh powder; and then, removing impurities out of the other 10 traditional Chinese herbs, drying and crushing into 120-mesh powder, and uniformly mixing with the cooked panax notoginseng powder; preparing into traditional Chinese medicine pellets, and coating an enteric coating with ethyl cellulose, shellac or algae colloid; and finally filling into capsules. The invention has the advantages of scientific compatibility, low cost, easy production, favorable administration effect and no side effect and has favorable economic and social benefits.

Disclosed is the novel use of TRIM24 and RIP3 as biomarkers for diagnosing osteoarthritis, in which it is first identified that TRIM24 and RIP3 can be used as biomarkers for diagnosing osteoarthritis by confirming the tendency of TRIM24 expression to decrease and RIP3 expression to increase at the onset of osteoarthritis. These two proteins are useful in confirming the change in the expression level from the onset of osteoarthritis, thus enabling early diagnosis of osteoarthritis and effectively blocking the progression of osteoarthritis at an early stage.

The invention discloses a traditional Chinese medicine decoction for treating degenerative osteoarthritis. The traditional Chinese medicine decoction is prepared from the following traditional Chinese medicinal materials in parts by weight: 15 parts of radix rehmanniae preparata, 20 parts of lycium chinense, 18 parts of astragalus membranaceus, 12 parts of black pebbles, 8 parts of lagoecia cuminoidesL. Seeds, 10 parts of carthamus tinctorius, 12 parts of dorema ammoniacum, 6 parts of radix achyranthis bidentatae, 20 parts of tragacanth, 6 parts of arctium lappa, 6 parts of bombyx batryticatus, 25 parts of phlogacanthus curviflorus, 10 parts of gossypium herbaceum, 5 parts of sapium baccatum, 6 parts of cana valia virosa, 6 parts of sedum aizoon and 6 parts of radix trichosanthis. Clinical experiments show that through selecting appropriate herbs and a matching ratio, the traditional Chinese medicine decoction provided by the invention has remarkable curative effects on treating degenerative osteoarthritis, and is safe and free of toxic and side effects.

The invention discloses a preparation method and application of a pharmaceutical composition for treating knee degenerative osteoarthritis. The preparation method of the pharmaceutical composition comprises the steps of collecting autologous fat, obtaining autologous fat micro-fragments, culturing adipose-derived mesenchymal stem cells and preparing a preparation. The preparation prepared by the method disclosed by the invention is used for treating patients with knee degenerative osteoarthritis, the patients are in a horizontal position, side knee joints are straightened during treatment, feet are kept in a neutral position, puncture parts are fully disinfected, hydrops of the patients with more joint hydrops are firstly pumped, fragments are removed by using an arthroscope, about 5-15ml of the prepared preparation is injected into the patients with a needle head after successful puncture, and bending and stretching the movable joint are performed for many times after injection. After the preparation is injected, knee joint pain is relieved, spasm is relieved, and knee joint functions are improved.

The invention discloses a traditional Chinese medicine for treating pain of rheumatoid arthritis. The traditional Chinese medicine is characterized by comprising the following components in percentage: 25% of manis pentadactyla, 25% of scorpions, 25% of centipedes and 25% of peach kernels. The preparation method and administration method comprise the following steps: drying the components, grinding into powder to pass through a No.6 sieve, uniformly mixing, and sub-packaging the powder in a bag with the weight of 3 grams; and adding a medicine bag into about 50ml of hot old wine each time to be taken before sleep, wherein the medicine is taken by one dose per day, and a course of treatment lasts 30 days. The problem that the existing pain-relieving medicine is poor in curative effect of treating degenerative osteoarthritis is solved, and the traditional Chinese medicine is suitable to be taken for treating degenerative osteoarthritis such as rheumatism, rheumatoid arthritis and osteoproliferation.

The invention belongs to the technical field of biomedicines and in particular discloses a preparation method for preparing a transdermal patch for treating osteoarthritis by utilizing small-molecularactive peptide and novel application. The biological external use type transdermal patch containing the small-molecular active peptide is prepared from the small-molecular active peptide and a hydrogel adhesive; the preparation method of the transdermal patch comprises the following steps: carrying out mixed enzymolysis on fresh animal thigh bones or backbones and muskmelon seeds; carrying out ultrafiltration to obtain supernatant with the molecular weight of 5000 Daltons or lower; uniformly mixing the supernatant with a prepared hydrogel matrix according to a proper ratio and coating and drying to obtain the external use type transdermal patch containing the small-molecular active peptide. The transdermal patch disclosed by the invention has a very good effect of improving degenerative osteoarthritis.