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Preparation method and application of pharmaceutical composition for treating knee degenerative osteoarthritis

A technology for knee osteoarthritis, composition, applied in the field of medicine, to achieve the effect of improving knee joint function, spasm relief, and pain relief

Pending Publication Date: 2021-05-21
安迪博斯生命医学研发(天津)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This cartilage does not function as normal cartilage to repair the joint surface

Method used

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  • Preparation method and application of pharmaceutical composition for treating knee degenerative osteoarthritis

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Embodiment Construction

[0021] The present invention will be specifically described below in conjunction with specific embodiments.

[0022] Autologous fat collection: Prepare 500ml of normal saline, 50ml of 2% lidocaine and 1ml of 0.1% epinephrine, and prepare Koshik's solution during the operation to prepare for the operation. During the operation, the patient was placed in a supine position on the operating table to fully expose the patient's abdomen, and a sterile drape was laid after routine disinfection. After giving local anesthesia at 5cm above the anterior superior iliac spine on both sides, use an anesthesia puncture needle to perform full infiltration anesthesia with 120ml of Koshik’s solution on each fat site. The obtained adipose tissue was left to stand for 3-5 minutes and then transferred to a 100ml preservation solution containing 79ml of 79% DMEM, 20ml of 20% human albumin, 0.5ml of 0.5% penicillin, and 0.5% of chain Mycin 0.5ml, the collection bottle is stored at 4°C.

[0023] Acq...

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Abstract

The invention discloses a preparation method and application of a pharmaceutical composition for treating knee degenerative osteoarthritis. The preparation method of the pharmaceutical composition comprises the steps of collecting autologous fat, obtaining autologous fat micro-fragments, culturing adipose-derived mesenchymal stem cells and preparing a preparation. The preparation prepared by the method disclosed by the invention is used for treating patients with knee degenerative osteoarthritis, the patients are in a horizontal position, side knee joints are straightened during treatment, feet are kept in a neutral position, puncture parts are fully disinfected, hydrops of the patients with more joint hydrops are firstly pumped, fragments are removed by using an arthroscope, about 5-15ml of the prepared preparation is injected into the patients with a needle head after successful puncture, and bending and stretching the movable joint are performed for many times after injection. After the preparation is injected, knee joint pain is relieved, spasm is relieved, and knee joint functions are improved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation method and application of a pharmaceutical composition for treating knee osteoarthritis. Background technique [0002] Knee degenerative osteoarthritis (KOA) is mainly characterized by bone spur formation and cartilage degeneration, which is more common in middle-aged and elderly people, and the symptoms gradually aggravate with age. Common symptoms of knee osteoarthritis are pain, dysfunction of the affected limb, and degeneration of muscle strength. Conventional treatment methods are mainly to improve joint function and relieve pain. However, patients often have recurrent symptoms during conventional treatment. Although the application of non-steroidal anti-inflammatory drugs can relieve pain, it cannot eliminate the cause, delay or reverse the degeneration of articular cartilage, and it is easy to relapse and cause digestive system, liver and kidney function damage afte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61P29/00A61P19/02
CPCA61K35/28A61P29/00A61P19/02
Inventor 任贺张美荣孙岳蒋鲁亚
Owner 安迪博斯生命医学研发(天津)有限公司
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