Medicine compound preparation for treating osteoarthritis and preparation method of medicine compound preparation

A compound preparation and osteoarthritis technology, applied in the field of biomedicine, can solve the problems of discomfort, joint swelling, large injection dose, etc., and achieve the effect of avoiding joint swelling, slowing down the progression of osteoarthritis, and preventing and developing osteoarthritis

Active Publication Date: 2020-01-24
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sodium hyaluronate is currently one of the most effective and widely used drugs for relieving arthritis symptoms on the market. Its efficacy in protecting joints and delaying or curbing joint degeneration has been recognized to a certain extent. Significant joint swelling and discomfort after the injection

Method used

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  • Medicine compound preparation for treating osteoarthritis and preparation method of medicine compound preparation
  • Medicine compound preparation for treating osteoarthritis and preparation method of medicine compound preparation
  • Medicine compound preparation for treating osteoarthritis and preparation method of medicine compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] The preparation of embodiment 1 compound injection

[0069] S1: To make solution, take 40 μg of Sema 3a human recombinant protein and dissolve it in 10 mL of sodium hyaluronate injection, vortex fully to dissolve, and make Sema 3a-sodium hyaluronate compound injection with a Sema 3a protein concentration of 4 μg / mL;

[0070] S2: Activated carbon treatment, add 0.2% of the total amount of the solution to the medicinal liquid and use activated carbon adsorption treatment;

[0071] S: 3: primary filtration, filter the liquid medicine with filter paper;

[0072] S4: Sterilize by filtration, use a microporous filter membrane with a pore size of 0.22 μm to sterilize the medicinal solution and remove the heat source;

[0073] S5: Subpackaging the medicinal solution in units of 2 mL, filling and sealing, to obtain an injection solution.

Embodiment 2

[0074] The preparation of embodiment 2 compound injection

[0075] The preparation method was the same as that in Example 1, except that in step S1, 60 μg of Sema 3a human recombinant protein was dissolved in 10 mL of sodium hyaluronate injection, and fully shaken to dissolve, so that the Sema 3a protein concentration was 6 μg / mL.

Embodiment 3

[0076] The preparation of embodiment 3 compound injections

[0077] The preparation method was the same as that in Example 1, except that in step S1, 90 μg of Sema 3a human recombinant protein was dissolved in 10 mL of sodium hyaluronate injection, and fully shaken to dissolve, so that the Sema 3a protein concentration was 9 μg / mL.

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Abstract

The present invention discloses a medicine compound preparation for treating osteoarthritis. The compound preparation is preferably a compound injection and comprises a nerve guiding factor Sema and asodium hyaluronate injection. A concentration of the nerve guiding factor Sema in the sodium hyaluronate injection is 4-9 [mu]g/mL. In a preferred embodiment, the nerve guiding factor Sema is selected from Sema 3a protein. Results of clinical trials show that the injection prepared by combination of the nerve guiding factor Sema 3a protein and the sodium hyaluronate injection has a superior therapeutic effect for patients with early stage degenerative osteoarthritis than that of a sodium hyaluronate injection treatment alone.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a drug compound preparation for treating osteoarthritis and a preparation method thereof. Background technique [0002] Osteoarthritis (OA) refers to a synovial joint disease characterized by cartilage loss and periarticular bone reaction, also known as osteoarthritis, degenerative osteoarthritis, hypertrophic or hypertrophic arthritis, etc. Most common rheumatic disease worldwide. Osteoarthritis is the degenerative injury of articular cartilage, reactive hyperplasia of joint margins and subchondral bone caused by aging, obesity, strain, trauma, congenital abnormalities of joints, joint deformities and many other factors. Osteoarthritis is the most common joint disease among middle-aged and elderly people. According to survey research, the prevalence rate of people over 60 years old can reach 50%, and that of people over 75 years old can reach 80%. The disability rate of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/19A61K9/08A61K47/36A61P19/02A61P19/08A61P19/04A61P29/00
CPCA61K38/19A61K9/08A61K9/0019A61K47/36A61P19/02A61P19/08A61P19/04A61P29/00Y02A50/30
Inventor 黄石书宁宁陈佳丽李佩芳吴迪伟尤炫合
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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