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Use of snow ganoderma lucidum total saponin in preparing analgesic medicine

A technology of total saponins and analgesics, applied in the application field of total saponins of Xue Lingzhi in the preparation of analgesics, can solve the problems of ulcers, bleeding and even perforation, there is no total saponins of Xue Lingzhi, and complications such as induced bleeding can be achieved. Easy to popularize, non-toxic and side-effects, definite curative effect

Inactive Publication Date: 2009-03-18
周以智
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is strictly limited in clinical application: the other category is non-opioid analgesics such as compound aspirin, Qutong tablets, etc., but they are limited to the treatment of mild pain, and are prone to gastrointestinal ulcers, bleeding and even perforation , easy to cause nephrotoxicity, induce hemorrhagic complications, produce sedation, restlessness and hallucinations, and limit treatment side effects
There is no report on the use of total saponins of snow ganoderma lucidum for analgesia

Method used

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  • Use of snow ganoderma lucidum total saponin in preparing analgesic medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Analgesic experiment of total saponins of Snow Ganoderma lucidum on mice writhing induced by acetic acid:

[0016] 80 Kunming mice were randomly divided into 8 groups, i.e. normal saline group, aspirin group 200mg / Kg, CO12 high dose group (200mg / Kg), middle dose group (100mg / Kg), low dose group (50mg / Kg ), CO13 high-dose group (200mg / Kg), middle-dose group (100mg / Kg), low-dose group (50mg / Kg), 10 in each group. Continuous intragastric administration for 3 days, 2 times a day. One hour after the last gavage, 0.2 ml / mouse of 0.5% acetic acid solution was intraperitoneally injected into the mice of each group. Then, taking abdominal inversion, limb extension and buttock elevation as pain response indicators, the number of writhing reactions within 15 minutes was observed. The results are shown in Table 1.

[0017] Table 1 Analgesic results of writhing method of extract of Snow Ganoderma lucidum (x±s, n=10)

[0018]

Embodiment 2

[0020] Analgesic experiment of total saponins of Snow Ganoderma lucidum on hot plate method in female mice

[0021] Female mice were placed on a metal hot plate at (55±0.5)°C, and mice with a pain threshold of 5 to 30 s were selected, and randomly divided into a normal saline group, a positive drug group, and a test drug group according to the pain threshold, with 10 mice in each group , each group was administered orally (0.2mL / 10g), once a day for 7 days. The pain threshold was measured again at different times after the last administration, and the increase in the pain threshold after the drug was taken as the index for comparison between groups. The results are shown in Table 2.

[0022] Table 2 Analgesic results of snow ganoderma lucidum extract hot plate method (x±s, n=10)

[0023]

[0024] Experiments have proved that: Snow Ganoderma lucidum has a good inhibitory effect on the pain induced by acetic acid and hot plate method in mice. It is used clinically as an an...

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Abstract

The invention relates to an application of Arenaria brevipetala total saponin for preparing analgesics. Arenaria brevipetala total saponin is prepared into dosage forms, such as tablets, capsules, oral liquid, medicinal granules, injection and the like, for treating naturopathic pain, postoperative pain, cancer pain and psychogenic pain. Arenaria brevipetala total saponin has the functions of dispelling and relieving pains a patient suffers.

Description

technical field [0001] The invention relates to a new application of the total saponins of the snow ganoderma lucidum, in particular to the application of the total saponins of the snow ganoderma lucidum in the preparation of analgesics. Background technique [0002] The main source of pain is chronic neuropathic pain, including postherpetic neuralgia, diabetic neuralgia, trigeminal neuralgia, glossopharyngeal neuralgia, chronic neck, shoulder, waist and leg pain, soft tissue pain such as myofascial pain, advanced cancer pain, and various other chronic intractable pains. Pain diseases have become a worldwide problem, and the reports and researches on chronic pain are increasing, arousing the attention of various aspects. [0003] Commonly used analgesics can be roughly divided into two categories, one is opioid analgesics, such as pethidine, morphine, etc. Although this type of analgesic has a certain analgesic effect, it will produce drug resistance and physical dependence...

Claims

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Application Information

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IPC IPC(8): A61K36/36A61P25/04A61P29/00
Inventor 周以智徐庆龚受基冯梅
Owner 周以智
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