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Compound

A technology of compounds and drugs, applied in the field of preparation of drugs for the prevention and treatment of cancer pain, which can solve the problems of limited opioid effect, gastrointestinal damage or kidney damage, and decreased analgesic effect of morphine

Inactive Publication Date: 2014-02-19
史克勇
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  • Abstract
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  • Claims
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Problems solved by technology

However, non-opioid analgesics NSAIDs are known to be prone to side effects such as gastrointestinal damage or kidney damage
It is also known that morphine, an opioid analgesic, has constipation, nausea, and vomiting as typical side effects, and withdrawal symptoms due to sudden discontinuation or reduction of the dose
In addition, neuropathic pain is also included in cancer pain, and since it is pain caused by damage to peripheral nerves or central nerves, the effect of opioids is limited
In addition, when morphine is administered chronically, anti-opioid substances such as cholecystokinin or neuropeptide Y are enhanced, resulting in a decrease in the analgesic effect of morphine and the formation of analgesic resistance

Method used

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Embodiment 1

[0008] Example 1. Evaluation of Drug Efficacy for Alleviating Cancer Pain

[0009] Animal modeling: After the animal was anesthetized, the left hind limb was sheared, the skin of the femur and tibia was disinfected with 75% ethanol, and a skin incision about 0.5-1.0 cm long was made at the knee joint along the direction of the rectus femoris tendon to carefully expose the patella. Use a disposable sterile 1mL syringe needle to puncture the patella along the long axis of the femur, then replace it with a 10μL syringe into the femoral medullary cavity, and slowly inject 10μL of Lewis mouse lung cancer cell solution (containing 3×10 5 cells) to the femur. After the injection, the needle hole was sealed with bone wax, the wound was cleaned, and the skin was sutured. The left patella of the animals in the sham operation group was injected with an equal volume of normal saline, and the rest of the operations were the same as those in the model group, while the blank group received ...

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Abstract

The invention belongs to the field of medicine technology, particularly relates to an application of a compound having the following structural formula as described in the specification in preparation of cancer pain medicines, and also relates to a pharmaceutical composition containing the compound.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular to 7S, 8R, 17S-trihydroxy-4Z, 9E, 11E, 13Z, 15E, 19Z-docosahexaene-N-cyclobutylamide in the preparation of cancer pain medicine in the application. Background technique [0002] Pain is one of the most common tumor-related symptoms, and pain is defined as "a sensory and emotional experience associated with actual or potential tissue damage or similar damage". Cancer pain refers to the pain caused by cancer, cancer-related lesions and anti-cancer treatment. Cancer pain is often chronic pain. Pain is a common symptom of cancer patients. About 1 / 4 of newly diagnosed cancer patients, 1 / 3 of cancer patients receiving treatment and 3 / 4 of advanced cancer patients have pain. Cancer pain patients may survive for months or years. Without proper analgesic treatment, patients will endure pain for a long time, which will greatly affect their activities, sleep, mood and overall quality of life. Can...

Claims

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Application Information

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IPC IPC(8): C07C235/28A61K31/16A61P35/00A61P29/00A61P25/04
Inventor 不公告发明人
Owner 史克勇
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