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Chinese medicinal composition for treating cancerous pain and preparation method thereof

A technology of cancer pain and composition, which is applied in the field of traditional Chinese medicine, can solve the problems of analgesics with large toxic and side effects, poor analgesic effect, addiction, and strong dependence for patients, and achieve low price and good clinical analgesic effect , clinically significant effect

Inactive Publication Date: 2010-03-17
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the "three-step drug analgesic method" vigorously promoted by the World Health Organization (WHO) is used to control cancer pain. Although the curative effect is relatively accurate, long-term use of analgesics has severe side effects, addiction, and dependence, and is affected by patients. Limitation of tolerance, resulting in poor analgesic effect in some patients

Method used

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  • Chinese medicinal composition for treating cancerous pain and preparation method thereof
  • Chinese medicinal composition for treating cancerous pain and preparation method thereof
  • Chinese medicinal composition for treating cancerous pain and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation method of embodiment 1 Aitongping capsule

[0027] Among the Liuwei original medicines of Aitongping preparation, Piper longum and Boswellia chinensis were extracted twice with 70% ethanol, the first time was added 7 times the amount, and the second time was added 5 times the amount, each time for 2 hours. Shufu, Zhaxiu, Zhibaifuzi, and Zhitianxing four flavors are added to water and decocted twice, adding 11 times the amount for the first time, and 10 times the amount for the second time, each time for 2 hours; combine the water extracts and concentrate to relative density From 1.05 to 1.09, add 95% ethanol until the alcohol concentration is 60%, make it precipitate, let it stand for 18 hours, take the supernatant and combine it with the alcohol extract of Piper longum and Boswellia chinensis. Alcohol combined liquid, 0.085Mpa, 65-70 ℃ under reduced pressure film, concentrated to relative density 1.02-1.05 (60 ℃). The concentrated solution is spray-dri...

Embodiment 2

[0032] Embodiment 2 Aitongping is stimulated by acetic acid to cause the drug efficacy test of mouse pain

[0033] The KM mice were randomly divided into four groups, and each group was intragastrically administered with the following doses.

[0034] (1) Blank control group: distilled water 20ml / kg;

[0035] (2) Tramadol group: 0.06g / kg;

[0036] (3) Aitongping group I: 9.0g / kg;

[0037] (4) Aitongping II group: 36.0 g / kg.

[0038] After the four groups of mice were administered for 1 hour, each mouse was intraperitoneally injected with 0.5% acetic acid 0.2ml / only, and observed the number of animals and times of writhing reactions in the mice of each group within 15 minutes after the injection of acetic acid. The results are shown in Table 2 .

[0039] The influence of table 2 Aitongping on the pain response of mice caused by acetic acid (twisting method) (X ± S)

[0040]

[0041] Note: *p<0.05, **p<0.01, compared with blank control group

[0042] The results showed t...

Embodiment 3

[0043] Example 3 Effect of Aitongping on Pain Response of Mice Induced by Electrical Stimulation

[0044] Use the YSD-4 pharmacology and physiology multipurpose instrument to perform the following determinations (setting parameters: continuous, time 0.5s, frequency 8Hz):

[0045] Put the mouse on the conductive copper wire board first, adjust the voltage output button after power on, so that the voltage changes from low to high, and record the time with a stopwatch. When the mouse screamed for the first time, the power was cut off immediately, and the voltage and frequency values ​​were recorded as the pain threshold of the mouse (if the pain threshold reached the pain threshold for more than 15 seconds before the medication, those who reached the pain threshold for more than 15 seconds were excluded).

[0046] Then take the KM mice and divide them into four groups at random, each group is administered by intragastric administration respectively:

[0047] (1) Blank control gr...

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Abstract

The invention relates to a Chinese medicinal composition for treating cancerous pain, which is called as Aitongping for short. The Chinese medicinal composition is prepared from the following raw materials in portion by weight: 3 to 5 portions of drug armadillidium, 4 to 6 portions of pariphyllin, 3 to 5 portions of piper longum, 3 to 6 portions of prepared rhizoma typhonii, 1 to 3 portions of prepared frankincense, and 2 to 6 portions of prepared rhizoma arisaematis. The invention also provides a preparation method for the Aitongping. Pharmacology and medicament effect and clinical application prove that the Aitongping has good abirritation, improves the life quality of a cancerous person, has a good anticancer effect, and enhances nonspecific immunity function and cellular immune function remarkably. The remarkable clinical cure efficiency is 53 percent; and the total efficiency is 90 percent. The preparation has abundant medicinal sources, low cost, convenient medicament administration, no obvious toxic and side effect, and good development prospect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cancer pain and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Cancer pain is the most common and most difficult symptom of cancer. Due to the aggravation and strong stimulation of pain, it directly affects the patient's appetite, sleep, psychological condition and treatment effect, and is one of the important reasons why malignant tumor patients lose confidence in treatment and desire for survival. one. There are about 7 million new cancer patients in the world every year, 30-50% of which are accompanied by pain. There are 2 million cancer patients in my country, and 1.6 million new patients each year. According to the survey, the incidence of cancer pain in my country is 51.5%. According to the world The World Health Organization (WHO) reported that about 3.5 to 4 million cancer patients around the wor...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K9/00A61K9/16A61K9/20A61K9/48A61P25/04A61P29/00A61K35/64
Inventor 吴勉华程海波郭立玮许惠琴朱华旭
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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