Cancer pain treatment medicine with high optical purity

A technology for cancer pain and medicine, which is used in the preparation of medicines for preventing and treating cancer pain, in the field of compounds with high optical purity, which can solve the problem of limited opioid effect, decreased analgesic effect of morphine, and easy occurrence of gastrointestinal damage or kidney damage. And other issues

Inactive Publication Date: 2013-07-10
史克勇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is known that non-opioid analgesics NSAIDs are prone to side effects such as gastrointestinal damage or kidney damage; opioid analgesics such as morphine are known to have side effects such as constipation, nausea, and vomiting, and there are also side effects caused by sudden discontinuation or reduction of dosing. Withdrawal symptoms caused by drug dosage, social problems caused by addiction are the most important
In addition, neuropathic pain is also included in cancer pain, and since it is pain caused by damage to peripheral nerves or central nerves, the effect of opioids is limited
In addition, when morphine is administered chronically, anti-opioid substances such as cholecystokinin or neuropeptide Y are enhanced, resulting in a decrease in the analgesic effect of morphine and the formation of analgesic resistance

Method used

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  • Cancer pain treatment medicine with high optical purity
  • Cancer pain treatment medicine with high optical purity
  • Cancer pain treatment medicine with high optical purity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1. Evaluation of Drug Efficacy for Alleviating Cancer Pain

[0018] Animal modeling: After the animal was anesthetized, the left hind limb was sheared, the skin of the femur and tibia was disinfected with 75% ethanol, and a skin incision about 0.5-1.0 cm long was made at the knee joint along the direction of the rectus femoris tendon to carefully expose the patella. Use a disposable sterile 1mL syringe needle to puncture the patella along the long axis of the femur, then replace it with a 10μL syringe into the femoral medullary cavity, and slowly inject 10μL of Lewis mouse lung cancer cell solution (containing 3×10 5 cells) to the femur. After the injection, the needle hole was sealed with bone wax, the wound was cleaned, and the skin was sutured. The left patella of the animals in the sham operation group was injected with an equal volume of normal saline, and the rest of the operations were the same as those in the model group.

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to application of a high-optical-purity compound shown in a general formula (I) in preparation of a medicine for treating a cancer pain. R is defined in the specification. The invention also relates to a pharmaceutical composition including the compound.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a compound with high optical purity effective for treating cancer pain and the application of the compound in preparing medicines for preventing and treating cancer pain. Background technique [0002] Pain is one of the most common tumor-related symptoms, and pain is defined as "a sensory and emotional experience associated with actual or potential tissue damage or similar damage". Cancer pain refers to the pain caused by cancer, cancer-related lesions and anti-cancer treatment. Cancer pain is often chronic pain. Pain is a common symptom of cancer patients. About 1 / 4 of newly diagnosed cancer patients, 1 / 3 of cancer patients receiving treatment and 3 / 4 of advanced cancer patients have pain. Cancer pain patients may survive for months or years. Without proper analgesic treatment, patients will endure pain for a long time, which will greatly affect their activities, sleep, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/732A61K31/23A61P35/00A61P29/00
Inventor 史克勇
Owner 史克勇
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