Capparis acutifolia sweet exact and preparation method and application thereof

A unique extraction technology, applied in the field of medicine, can solve the problems of complex ingredients, unclear effective parts, unstable therapeutic effect, etc., and achieve the effect of simple process, reasonable method design and low cost

Active Publication Date: 2010-07-21
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the clinical application of Lonely Thousand Miles is mostly simple processing and use, which can be taken orally or externally; crude extraction preparations have complex components, and generally have the shortcomings of being thick, large, and black. Difficult to control and unstable treatment effects
Under the guidance of pharmacodynamics, it is urgent to screen the effective parts of Lonely Thousand Miles and carry out applied research. However, there is no report on the extraction process and optimal extraction conditions of the effective parts of Lonely Thousand Miles. Research reports on anti-inflammatory and anti-rheumatic pharmacology

Method used

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  • Capparis acutifolia sweet exact and preparation method and application thereof
  • Capparis acutifolia sweet exact and preparation method and application thereof
  • Capparis acutifolia sweet exact and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 The preparation of the effective part of a thousand miles alone (i.e. the extract of a thousand miles alone)

[0040] Get about 2 kilograms of the crushed Lone Walking Thousand Miles (rhizome), add 12 times the amount (weight: volume) of 95% ethanol to extract for 7 days, filter the residue and then use 10 times the amount of 95% alcohol to extract it for 5 days, and filter the residue again Extract with 10 times the amount of 95% ethanol for 3 days, combine the filtrates, recover the ethanol under reduced pressure, and obtain the extract. The extract is mixed with 60g of silica gel and put on a silica gel column, eluting with petroleum ether, chloroform, ethyl acetate, n-butanol and acetone respectively, and recovering the solvent under reduced pressure, the obtained chloroform parts and ethyl acetate parts are respectively 5.8g and 6.1 g.

Embodiment 2

[0041] Example 2 The preparation of the effective fraction of traveling thousands of miles alone

[0042] Take about 2 kg of crushed Lone Walking Thousand Miles (rhizome), add 12 times the amount of 85% ethanol and sonicate (100KHZ) 3 times, each time for 45 minutes, to obtain about 86.2 g of extract. After the extract was mixed well with 60g of silica gel, it was extracted 3 times with petroleum ether, chloroform, ethyl acetate, n-butanol, and acetone under reflux, each time with 10 times the amount of solvent, and extracted for 1 hour; the solvent was recovered under reduced pressure, and the obtained chloroform part , ethyl acetate parts were 9.2g and 10.9g.

Embodiment 3

[0043] Example 3 The preparation of the effective part of traveling thousands of miles alone

[0044] Take about 2 kilograms of crushed Lone Walker (rhizome), add 12 times the amount of 85% ethanol to reflux and extract 3 times, respectively for 2 hours, 1 hour, and 1 hour, to obtain about 95.2 g of extract. After the extract was mixed well with 60g of silica gel, it was extracted 3 times with petroleum ether, chloroform, ethyl acetate, n-butanol, and acetone under reflux, each time with 10 times the amount of solvent, and extracted for 1 hour; the solvent was recovered under reduced pressure, and the obtained chloroform part , ethyl acetate parts were 11.1g and 12.6g, respectively.

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PUM

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Abstract

The invention discloses a capparis acutifolia sweet exact and a preparation method and an application thereof. The capparis acutifolia sweet extract is obtained by taking roots and stems of plant-capparis acutifolia sweet, smashing, then carrying out heating reflux and cold soaking or leakage for extraction, carrying out vacuum concentration for obtaining a crude extract and using chloroform for extracting the crude extract, and can be applied in the preparation of drugs for treating neuropathic pain, treating inflammatory pain, treating cancer pain, treating diabetic pain, treating rheumaticpain, treating traumatic injury pain, treating sore throat, treating toothache or treating abdominal pain, and the capparis acutifolia sweet extract has great analgesic and anti-inflammation activityand obvious effect for Freund's complete adjuvant arthritis. The preparation process is characterized by low cost and easy realization of industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an extract of a thousand miles alone, a preparation method thereof and its application in the preparation of anti-inflammatory, analgesic and anti-rheumatic arthritis drugs. Background technique [0002] The dry root of Capparisacutifolia Sweet [C.membranacea Gardn.et Champ.] of the Capparaceae plant. Alias ​​button button (Guangdong milk source), membranous leaf mallet fruit vine, Duhulong, black snake, black hook banyan (Hainan), etc., produced in Guangdong, Guangxi, Jiangxi (Dayu), Fujian (Shaxian, Chong'an) , Yanping), Hunan (Yizhang), Taiwan; born in low-altitude shrubs, forests, wilderness or hillside roadsides. This product is a folk herbal medicine in southern my country. Flat in nature, bitter in the mouth, astringent, poisonous; Function promoting blood circulation and dispelling blood stasis, relieving spasm and relieving pain. It is used to treat rheum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P29/00A61P19/02A61P19/04A61P19/06A61P25/00A61P21/02A61K125/00
Inventor 邓亚利
Owner SOUTH CHINA AGRI UNIV
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