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Magnetic medicinal microball for directional breaking nerve back root and its preparing method

A spinal nerve and magnetic technology, applied in the field of magnetic drug microspheres for directional damage to the posterior root of the spinal nerve and its preparation, to achieve the effects of reducing complications, small trauma, and strong magnetic response

Inactive Publication Date: 2005-07-20
孙永海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the targeted destruction of the dorsal root of the spinal cord by nerve-damaging drugs is not only the key to reducing complications and ensuring the curative effect, but also the technical bottleneck for the promotion of NNB.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, physisorption method

[0029] Take 200mg of dextran gel with a diameter of 20uM, add Fe-containing 3 o 4 120mg of magnetic fluid, ultrasonically mixed, oscillating and adsorbing at room temperature, drying at 100°C, gently grinding to make magnetic dextran gel microspheres, dissolving 80mg of phenol in ethanol, and then ultrasonicating with magnetic dextran gel microspheres Mix, shake and adsorb at room temperature for 8 hours, vacuum-dry at room temperature, grind gently, sieve and weigh, pack and cap, 60 Co irradiated and sterilized to obtain the nerve-damaging agent magnetic microspheres of the present invention with a diameter of 20uM.

Embodiment 2

[0030] Embodiment 2, emulsification cross-linking embedding method

[0031] Dissolve 250mg of gelatin in 1ml of deionized water at 55°C to make a 25% gelatin solution, take 150mg of Fe 3 o 4 , 50mg of urea is ultrasonically mixed, get 20ml of liquid paraffin (containing 3% surfactant), drop the mixed solution into the constantly stirring liquid paraffin with a micro pump at 100ml / h, the stirring speed is 1800rpm, and the temperature is 60°C. After 10 minutes, change to ice bath, continue to stir for 1 hour, add 0.2ml of formaldehyde, stir for another 1 hour, add 20ml of isopropanol, stir for 10 minutes, centrifuge at 2000rpm, discard the supernatant, add 20ml of isopropanol, stir for 10min, 2000rpm Centrifuge, discard the supernatant, then wash 4 times with 10ml ether and acetone, dry in vacuum, sieve and weigh, pack and cap, 60 Co irradiated and sterilized to obtain the nerve-damaging agent magnetic microspheres of the present invention with a diameter of about 5uM.

[003...

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PUM

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Abstract

The present invention relates to a magnetic medicine microsphere for directively-destroying dorsal root of spinal nerve and its preparation method. It is formed from magnetic material, skeletno material and nerve destroying agent, and is made up by adopting the processes of physical adsorption or emulsifying, crosslinking and embedding. Said invention can be effectively used for curing obstinacy pain and pain of late cancer. It is a safe and effective nerve destroying agent.

Description

technical field [0001] The invention relates to magnetic drug microspheres for directional damage to the posterior roots of spinal nerves and a preparation method thereof. Specifically, the nerve-damaging agent is physically adsorbed or embedded in magnetic polymer microspheres through emulsification and cross-linking, and then injected into the subarachnoid space. Under the guidance of an external magnetic field, the magnetic drug microspheres gather in a direction to the posterior root of the spinal nerve, and the drug is gradually released, targeting the destruction of the posterior root of the spinal nerve—the sensory nerve, and can damage multiple pairs of spinal nerves under the guidance of an external magnetic field without affecting the anterior root of the spinal nerve— Motor nerves and other tissues, so as to achieve the purpose of treating intractable pain and advanced cancer pain. Background technique [0002] According to statistics, about 400,000 people die of ...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/05A61K47/30A61M31/00
Inventor 孙永海
Owner 孙永海
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