New preparation method for aspirin-containing compound preparation

Abstract

The invention discloses a new preparation method for an aspirin-containing compound preparation, which is characterized in that: the aspirin-containing compound preparation is an internal and external multi-layer preparation consists of aspirin, and aluminum glycinate and heavy magnesium carbonate which are alkaline medicines; and an insulation layer is formed between the internal and externally-applied medicines to prevent the aspirin from contacting the alkaline medicines directly. The aluminum glycinate can neutralize gastric acid, relieve gastric acid increase, pain in upper abdomen and other clinic symptoms and has effects of astringing and stopping bleeding; and the heavy magnesium carbonate is an antiacid medicine and can reduce the adverse irritation of aspirin to the stomach, obviously reduce rate of gastric mucosal erosion and ulcer, thereby protecting the stomach.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound preparation prepared from aspirin, aluminum glycylate, heavy magnesium carbonate and pharmaceutical auxiliary materials through a specific process. Background technique [0002] Aspirin has a history of more than 100 years, from pure salicylic acid first developed to acetylsalicylic acid improved by Hoffman, until later aspirin was introduced into the medical field by Bayer. Aspirin is both a prescription drug and an over-the-counter drug (OTC). This drug can affect the synthesis of prostaglandins, a strong thermogenic factor in the hypothalamus, and restore the normal function of the body temperature center to regulate body temperature. Aspirin also has analgesic, anti-inflammatory and anti-platelet aggregation effects. Aspirin has been widely used clinically, especially in the prevention and treatment of cardiovascular and cerebrovascular diseases. [0003] Aspirin has been...

AI Technical Summary

Problems solved by technology

This preparation alleviates the stimulation of aspirin to the stomach to a certain extent, but the upper and lower layers cannot completely relieve the stimulation of aspirin to the stomach

In foreign countries, internal and external packaging are often used, but the tablet press required for internal and external packaging is expensive and the stability of the preparation is poor.

And no matter whether it is the domestic upper and lower layers or the foreign inner and outer cladding, neither can solve the phenomenon that aspirin and alkaline drugs are easy to decompose after long-term contact