New preparation method for aspirin-containing compound preparation

An aspirin and preparation technology, which is applied in the field of compound preparations, can solve the problems that aspirin and basic drugs are easily decomposed, cannot completely relieve aspirin irritation, and the tablet press is expensive, etc., and achieves lower drug prices, easy operation, and money saving. Effect

Inactive Publication Date: 2011-09-28
JINAN RUIAN PHARMA DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This preparation alleviates the stimulation of aspirin to the stomach to a certain extent, but the upper and lower layers cannot completely relieve the stimulation of aspirin to the stomach
In foreign countries, internal and external packaging are often used, but the tablet press required for intern

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0014] The present invention is further illustrated by the form of examples below, but this should not be construed as a limitation of the present invention. All technologies realized by the above contents of the present invention belong to the scope of the present invention.

[0015] Aspirin 81g

[0016] Aluminum glycylate 11g

[0017] Heavy Magnesium Carbonate 22g

[0018] Lactose 90g

[0019] Microcrystalline Cellulose 8g

[0020] Talc powder 7g

[0021] Tartaric acid 3g

[0022] Gastric film coating 1.5g

[0023] Aspartame 0.1g

[0024] Sodium Carboxymethyl Cellulose 5g

[0025] 10% starch slurry 25ml

[0026] 1000 pieces

[0027] Preparation method: mix the prescribed amount of aspirin, tartaric acid and 85g lactose, wet granulate with 10% starch slurry, boil and dry; mix aspirin granules with 4g microcrystalline cellulose and 3.5g talcum powder, compress into tablets, pack and isolate layer: mix aluminum glyoxate, heavy magnesium carbonate, aspartame 0.1g, sod...

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Abstract

The invention discloses a new preparation method for an aspirin-containing compound preparation, which is characterized in that: the aspirin-containing compound preparation is an internal and external multi-layer preparation consists of aspirin, and aluminum glycinate and heavy magnesium carbonate which are alkaline medicines; and an insulation layer is formed between the internal and externally-applied medicines to prevent the aspirin from contacting the alkaline medicines directly. The aluminum glycinate can neutralize gastric acid, relieve gastric acid increase, pain in upper abdomen and other clinic symptoms and has effects of astringing and stopping bleeding; and the heavy magnesium carbonate is an antiacid medicine and can reduce the adverse irritation of aspirin to the stomach, obviously reduce rate of gastric mucosal erosion and ulcer, thereby protecting the stomach.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound preparation prepared from aspirin, aluminum glycylate, heavy magnesium carbonate and pharmaceutical auxiliary materials through a specific process. Background technique [0002] Aspirin has a history of more than 100 years, from pure salicylic acid first developed to acetylsalicylic acid improved by Hoffman, until later aspirin was introduced into the medical field by Bayer. Aspirin is both a prescription drug and an over-the-counter drug (OTC). This drug can affect the synthesis of prostaglandins, a strong thermogenic factor in the hypothalamus, and restore the normal function of the body temperature center to regulate body temperature. Aspirin also has analgesic, anti-inflammatory and anti-platelet aggregation effects. Aspirin has been widely used clinically, especially in the prevention and treatment of cardiovascular and cerebrovascular diseases. [0003] Aspirin has been...

Claims

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Application Information

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IPC IPC(8): A61K33/10A61K9/20A61K31/616A61K47/38A61K47/34A61K47/26A61P7/02A61P29/00A61K31/198
Inventor 胡清文高玉秋李启俊苑玉臣任晋云朱崇贺
Owner JINAN RUIAN PHARMA DEV
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