31 results about "Sensory cell" patented technology

A neuro-stimulation system employs a includes a stimulator which may include electrode devices and/or vibration elements. A controller may be employed to drive the stimulating elements with an electrical signal. In response to the electrical signal, the stimulating elements deliver electrical and/or mechanical stimulation to the body part. The stimulation may be an aperiodic stimulation and/or may be a subthreshold stimulation. In one embodiment, the stimulator is disposable and the processor determines usage of the stimulator and ensures that the stimulator is limited to a certain amount of use. Neuro-stimulation systems may be applied to sensory cells of body parts during movement of the body parts to induce neuroplastic changes. Such movement may involve a variety of therapeutic applications, e.g. in stroke patient therapy.

The invention provides a series of Galphaq protein variants that functionally couple to sensory cell receptors such as taste GPCRs (TRs) and olfactory GPCRs (ORs) in an overly promiscuous manner. According to the invention, the functional coupling can be determined, for example, by measuring changes in intracellular IP3, or calcium. In a particular embodiment, the Galphaq protein variants can be expressed in mammalian cell lines or Xenopus oocytes, and then evaluated using calcium fluorescence imaging and electrophysiological recording.

The invention discloses a novel micro ball sensor for sensing space environment changes and a manufacture method thereof. The sensor simulates a biological behavior that lateral lines of a fish identify and locate prey underwater, that is, the exposed lateral line canals in the neuromasts in the lateral lines can mechanically sense the vibration generated during the swim of underwater animals. Positioning is performed according to the time and phase difference that a vibration wave reaches different neuromasts underwater, and a motion signal is converted into a physiological electric signal to be transmitted to sensory cells to sense stimulation such as external water flow changes, low-frequency vibration, and temperature changes. By using a polyvinylidene fluoride direct piezoelectric effect, a spatial airflow change is imitated and sensed and a spatial vibration source is positioned. A single ball sensing unit senses the vibration by using the polyvinylidene fluoride and directly converts the vibration into electric signals so as to calculate a spatial airflow magnitude and angle. A plurality of ball sensing units are arranged in an array, calculate the airflow magnitude and orientation according to the time and phase difference that the vibration wave reaches different sensing units, and improve the spatial airflow magnitude and orientation calculation accuracy.

The present invention relates to a TRPV3 (transient receptor potential vanilloid 3) activity inhibitor, more precisely to a method for inhibiting TRPV3 activity including the step of treating isopentenyl pyrophosphate and a method for treating skin disease containing the step of administering isopentenyl pyrophosphate to a subject with skin disease or applying the same on the skin of the subject. Isopentenyl pyrophosphate of the present invention controls increase of sensory cell reactivity to current or migration and proliferation of skin cells induced by TRPV3, so that it can be effectively used for the development of a pain reliever or a therapeutic agent for skin disease.

The present application relates to silicone compounds, compositions, packaged products and displays comprising such silicone compounds, and processes for making and using such compositions, packaged products and displays comprising such compositions. Such compositions have improved deposition and retention properties that may impart improved benefit characteristics to a composition and/or situs yet which changes its hydrophilicity/charge when desired. Such silicone compounds solve the further problem of malodor reduction as, in addition to maldor masking, such compounds block a malodor's access to a sensory cell, yet leave such sensor cell open to other molecules, for example scent molecules. Thus, the malodor control technologies disclosed herein do not unduly interfere with the scent of the perfumed or unperfumed situs that is treated with the malodor control technology.

The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.

The present invention relates to novel aminoalkyl-oxazole and aminoalkyl-thiazole carboxylic acid amides that stimulate the endogenous regeneration of terminally differentiated cells in highly specialized organs, tissues and sensory epithelia in mammals in situ. The claimed low-molecular-weight compounds are able to induce corresponding cell biological changes such as dedifferentiation, proliferation and the subsequent terminal redifferentiation of cells of the normally post-mitotic tissue. The invention in particular relates to compounds with which a de novo formation of hair sensory cells in the organ of Corti can be obtained by inducing cell separation of supporting cells of the inner ear and hearing can be restored after hair cell loss. The compounds according to the invention for the first time enable a causal treatment of inner ear hardness of hearing caused, for example, by noise, ototoxic substances, symptoms of old age or genetic causes on the basis of regenerative biology. The invention further relates to methods for producing the compounds according to the invention, to the formulation (1) (2) thereof as pharmaceutical preparations and to the use thereof for producing pharmaceuticals for regenerative medicine.

The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.

The invention is directed to a replication-deficient adenoviral vector comprising a nucleic acid sequence encoding a human atonal homolog-1 (Hath1) protein operably linked to a human glial fibrillary acidic protein (GFAP) promoter. The invention also is directed to a composition and method utilizing the adenoviral vector to generate sensory cells in the inner ear of a human.

The present invention provides isolated nucleic acid and amino acid sequences of sensory cell-specific G protein gamma subunits, antibodies to these subunits, methods for detecting these nucleic acids and subunits, and screening for modulators of sensory cell-specific G protein gamma subunits Methods.

A hydrogel-lightguide based sensory system susceptible to a stimulus signal produced by ambient and stimulating sensory cells embedded in a hydrogel body of the system. Sensory cells generate an optical signal (in response to a user-defined triggering with excitation light or, alternatively, due to bioluminescence) the properties of which, determined based on detection of such signal with an optical detector device, provide characterization of the stimulus and information required for user-defined activation of emitter cells encapsulated in the hydrogel. When activated, emitter cells generate matter and/or light directed to interact with the ambient.