48 results about "Fovea centralis" patented technology

Methods for analyzing retinal tomography maps to detect patterns of optic nerve diseases such as glaucoma, optic neuritis, anterior ischemic optic neuropathy are disclosed in this invention. The areas of mapping include the macula centered on the fovea, and the region centered on the optic nerve head. The retinal layers that are analyzed include the nerve fiber, ganglion cell, inner plexiform and inner nuclear layers and their combinations. The overall retinal thickness can also be analyzed. Pattern analysis are applied to the maps to create single parameter for diagnosis and progression analysis of glaucoma and optic neuropathy.

An ophthalmic lens element (100) for correcting myopia in a wearer's eye is disclosed. The lens element (100) includes a central zone (102) and a peripheral zone (104). The central zone (102) provides a first optical correction for substantially correcting myopia associated with the foveal region of the wearer's eye. The peripheral zone (104) surrounds the central zone (102) and provides a second optical correction for substantially correcting myopia or hyperopia associated with a peripheral region of the retina of the wearer's eye. A system and method for dispensing or designing an ophthalmic lens element for correcting myopia in a wearer's eye is also disclosed.

Methods for analyzing retinal tomography maps to detect patterns of optic nerve diseases such as glaucoma, optic neuritis, anterior ischemic optic neuropathy are disclosed in this invention. The areas of mapping include the macula centered on the fovea, and the region centered on the optic nerve head. The retinal layers that are analyzed include the nerve fiber, ganglion cell, inner plexiform and inner nuclear layers and their combinations. The overall retinal thickness can also be analyzed. Pattern analysis are applied to the maps to create single parameter for diagnosis and progression analysis of glaucoma and optic neuropathy.

A gaze direction determining system and method is provided. A two-camera system may detect the face from a fixed, wide-angle camera, estimates a rough location for the eye region using an eye detector based on topographic features, and directs another active pan-tilt-zoom camera to focus in on this eye region. A eye gaze estimation approach employs point-of-regard (PoG) tracking on a large viewing screen. To allow for greater head pose freedom, a calibration approach is provided to find the 3D eyeball location, eyeball radius, and fovea position. Both the iris center and iris contour points are mapped to the eyeball sphere (creating a 3D iris disk) to get the optical axis; then the fovea rotated accordingly and the final, visual axis gaze direction computed.

The invention discloses a retina fovea centralis detection method based on a multi-feature model. The retina fovea centralis detection method comprises the following steps: 1) carrying out global prior feature extraction; 2) carrying out local prior feature extraction; 3) carrying out depth feature extraction; and 4) establishing a multi-feature-fusion fovea centralis detection model. Through global, local and depth feature information extraction of fovea centralis and effective fusion, accurate detection of the retina fovea centralis is finished. The method can effectively overcome the influence of fundus illumination noise, fundus lesions and abnormal blood vessel distribution on fovea centralis automatic detection, thereby improving fovea centralis detection precision and robustness, and providing more robust identity characteristic information for identity identification based on retinal images.

An interactive gazing vision training system comprises software loaded in a computer, gaming handle connected to the computer. Computer generated signal can be projected on projection screen after being input in projector. The total system can project 4-8 wickets controlled independently by gaming handle on projection screen. The gaming handle has buttons corresponding to each corresponding sighting direction. Sighting target in the wicket can wane continually under the control of the computer. Trainee sit at a place 2-5 m away from the projection screen, light ray emitted by any point on the projection screen enter the eyeball of the trainee via optical lens, and the hearth in the eye is located at a place 0.5-2mm in front of fovea centralis of niacula lutea retinae. The inventive interactive gazing vision training system integrates multiple modern theories for preventing and treating myopia, adopts the advantages of games, utilizes 3Dexaggeration technology, increases entertaining quality, and becomes an easily persistent eyes protection method.

Two problems arise when measuring length at the eye by short-coherence interferometry. First, the measurement focus and coherence window usually do not coincide. Second, the scanning process along the eye axis is time-consuming. Both result in poor signal quality and inaccurate measurements. The present application is directed to a short-coherence interferometer in which a right-angle mirror and focusing optics jointly carry out a periodic back-and-forth movement in such a way that the measurement beam focus which is generated by the focusing optics and imaged on the eye by relay optics is moved synchronously with the coherence window from the cornea along the optic axis of the eye to the fovea centralis. Further, different path lengths are generated in the measurement beam path and reference beam path by means of a plurality of reflectors, so that the scanning process is limited to distances which are smaller than the optical length of the eye. The present invention is advantageously implemented using on a fiber-optic interferometer. According to the invention, the reference interferometer arm and measurement interferometer arm are combined with the arms of a fiber-optic interferometer.

The invention provides a fundus OCT image recognition method and device, and the method comprises the steps: carrying out the recognition of a fundus OCT image through a neural network, and obtaininga recognition result related to lesion and fovea centralis; determining a region of interest according to the identification result; and determining the lesion degree according to the position and / orsize of the region of interest.

A display system divides a screen into regions and applies a different set of rendering / encoding parameters to each region. The system applies a first set of parameters to a first region that is beingviewed by a fovea of an eye of a user. The system may also apply a second set of parameters to a second region that is being viewed by a parafovea of the eye, and apply a third set of parameters to athird region that is being viewed by the area of the eye outside of the parafovea. The first set of parameters is selected to yield relatively high image quality, while the second set of parameters are yield intermediate quality, and the third set of parameters yield lower quality. As a result, the second region and the third region can be rendered, encoded, and transmitted with less computing power and less bandwidth.

ABSTRACT OF THE DISCLOSURE The newly discovered retinal ganglion cell photoreceptor melanopsin absent in the central fovea of the eye but distributed throughout the remaining human retinal body provides both non-visual biological / physiological input inducing circadian entrainment, and visual input affecting perceived brightness; this perceived brightness is not the object brightness commonly associated with luminance and perceived color of an object in central view, but the perception of brightness of a whole space or task background. Discussed are improvements to circadian lighting systems based on melanopsin stimulation whereby ambient and / or device background lighting may be temporally tuned over a range of prescribed color temperatures from a first subset of lighting having a higher melanopic content to a second subset of lighting having a lower melanopic content or vice versa in accordance with a desired circadian cycle, and in a manner where net light output is of a constant perceived brightness and color throughout temporal tuning.

A prism prescription value acquisition system that includes a calculation part for numerically transforming a fixation disparity amount (unit: angle), which indicates a degree at which the visual axis is shifted from the central fovea of the retina when a subject conducts visual fixation of a target, into a prism prescription value by multiplying the fixation disparity amount by a coefficient when the fixation disparity amount is within ±4 minutes. Herein, the prism prescription value is calculated according to the following equation: APver=kver*FDver, APhor=khor*FDhor providing that each of coefficients khor and kver satisfies the following conditions: 0.3≦kver≦0.7, 1.4≦khor≦2.0.

Provided is neuroprotective therapy for glaucoma which includes generating a micropulsed laser light beam having parameters and characteristics, including pulse length, power, and duty cycle, selectedto create a therapeutic effect with no visible laser lesions or tissue damage to the retina. The laser light beam is applied to retinal and / or foveal tissue of an eye having glaucoma or a risk of glaucoma to create a therapeutic effect to the retinal and / or foveal tissue exposed to the laser light beam without destroying or permanently damaging the retinal and / or foveal tissue and improve function or condition of an optic nerve and / or retinal ganglion cells of the eye.

The invention discloses a visual target tracking method of a bionic retina, and belongs to the field of photoelectric target tracking. According to the invention, the variable resolution characteristic of bionic retina imaging is mainly utilized, and the field of view is mapped to the logarithm polar coordinates for target tracking. Firstly, logarithm polar coordinate mapping imaging of a bionic retina is utilized, a target tracking algorithm is improved through the staring effect of a fovea centralis, the information compression effect of an edge and real-time parameters, redundant data are compressed, detail information of an interested target is enhanced, and the information acquisition efficiency in a view field range is improved. And meanwhile, target information in a scene is accurately grasped by utilizing singular points and imaging threshold judgment, and the reliability of target screening is improved. And finally, real-time target tracking is realized by comparing an eccentricity judgment algorithm with higher speed with the motion control module. Compared with a traditional method, under the condition of a large field of view and high resolution, real-time target tracking is achieved on the basis of a bionic retina vision mechanism, efficiency is higher, and precision is higher.

Two problems arise when measuring length at the eye by short-coherence interferometry. First, the measurement focus and coherence window usually do not coincide. Second, the scanning process along the eye axis is time-consumin g. Both result in poor signal quality and inaccurate measurements. The present application is directed to a short-coherence interferometer in which a right-angle mirror and focusing optics jointly carry out a periodic back-and-forth movement in such a way that the measurement beam focus which is generated by the focusing optics and imaged on the eye by relay optics is moved synchronously with the coherence window from the cornea along the optic axis of the eye to the fovea centralis. Further, different path lengths are generated in the measurement beam path and reference beam path by means of a plurality of reflectors, so that the scanning process is limited to distances which are smaller than the optical length of the eye. The present invention is advantageously implemented using on a fiber-optic interferometer. According to the invention, the reference interferometer arm and measurement interferometer arm are combined with the arms of a fiber-optic interferometer.

The invention discloses a method and a device for determining a macular fovea centralis position, and relates to the technical field of artificial intelligence such as smart medical treatment and computer vision. According to the specific implementation scheme, the method comprises the steps of determining a feature region from a to-be-processed fundus image, wherein the feature region comprises an optic disc region and a blood vessel region in the fundus image; adopting a pre-trained position prediction model to estimate the relative displacement of each feature point in the feature region relative to the macular fovea central fovea prediction position; based on the position information of each feature point and the relative displacement of the feature point, determining a mapping point corresponding to the feature point in the fundus image to obtain a mapping point set; and determining the position of the macular fovea based on the position information of each mapping point in the mapping point set. The positioning accuracy of macular fovea centralis is improved, and the influence of lesion shielding on the positioning accuracy can be avoided.

Lenses and methods are provided for improving peripheral and / or central vision for patients who suffer from certain retinal conditions that reduce central vision or patients who have undergone cataract surgery. The lens is configured to improve vision by having an optic configured to focus light incident along a direction parallel to an optical axis at the fovea in order to produce a functional foveal image. The optic is configured to focus light incident on the patient's eye at an oblique angle with respect to the optical axis at a peripheral retinal location disposed at a distance from the fovea, the peripheral retinal location having an eccentricity between −30 degrees and 30 degrees. The image quality at the peripheral retinal location is improved by reducing at least one optical aberration at the peripheral retinal location. The method for improving vision utilizes ocular measurements to iteratively adjust the shape factor of the lens to reduce peripheral refractive errors.

The invention discloses an SD-OCT image macular fovea centralis center positioning method. The method comprises the following steps: segmenting an inner boundary film layer and a Bloom film layer of an SD-OCT image; extracting each column of pixels between the inner boundary film layer and the Bloom film layer as features; training a random forest classifier to segment a fovea centralis non-vascular region, and calculating the geometric center position of the fovea centralis non-vascular region as the rough center position P1 of the macular fovea centralis; a retina thickness image is generated within a certain range with P1 as the center; judging whether the retina in the area is sunken or not, and if yes, taking the position at the minimum thickness value as a new foveal fovea central position P2; if not, the P2 is still the position of the P1; and searching a central concave high-reflection region around the position P2, if the high-reflection region exists, taking the central position of the high-reflection region as a final central concave central position P3, and otherwise, taking the P3 as the position P2. Compared with the conventional method for positioning only accordingto the thickness change of the retina, the robustness and the precision of the method are greatly improved.

Systems and methods are provided for rendering of a dual eye-specific display. The system tracks the user's eye movements and / or positions, in some implementations, based on electroencephalography (EEG) of the user, to correctly label the central (foveal) and peripheral (extra-foveal) areas of the display. Foveal data is fully rendered while extra-foveal data is reduced in resolution and, in someimplementations, shared between the two displays.

A process for performing retinal phototherapy or photostimulation includes generating a laser light that creates a therapeutic effect to retinal and / or foveal tissues exposed to the laser light without destroying or permanently damaging the retinal or foveal tissue. The laser light is applied to a first treatment area of the retina. After a predetermined interval of time, within a single treatmentsession, the laser light is reapplied to the first treatment area of the retina. During the interval of time between the laser light applications to the first treatment area, the laser light is applied to one or more additional areas of the retina that is spaced apart from the first treatment area and one another. The laser light is repeatedly applied to each of the areas to be treated until a predetermined number of laser light applications to each area to be treated has been achieved.

Systems and methods for tracking eye movement during a diagnostic procedure include a retina imaging system configured to capture a first plurality of images of an eye and detect a presence of a fovea, an eye tracker configured to capture a second plurality of images of the eye and track a position and orientation of the eye; and a control processor configured to synchronize the first and second plurality of images, determine a time at which the fovea is detected in the first plurality of images, and determine one or more images from the second plurality of images to be classified as representative of fixation. The classified images are analyzed to determine eye fixation status during the diagnostic procedure based on eye tracking data.

The invention belongs to the technical field of medical image processing, and aims to realize real-time fundus optic disc and fovea centralis detection based on deep learning and improve the detectionprecision and speed of the optic disc and the fovea centralis. Therefore, according to the technical scheme, the fundus optic disc and fovea centralis real-time detection device and method based on deep learning are adopted, a fundus optic disc and fovea centralis detection network based on a single-stage multi-frame detection SSD algorithm is constructed, parameters of a network model are optimized through multiple times of iterative learning, and the detection precision of the network model is improved. And real-time positioning of the optic disc and the fovea centralis center in a large number of fundus images is realized. The method is mainly applied to medical image processing occasions.

The invention relates to a method for realizing flexible central fovea imaging based on a rotary biprism imaging system. The method comprises the steps of S1, constructing a rotary biprism imaging system; S2, constructing a fitness function, and defining a definition and calculation method of a fitness value; S3, determining a region of interest and the number of sub-images, and solving a prism rotation angle by using a particle swarm optimization algorithm; S4, sequentially adjusting the rotation angles of the prisms according to the result of the particle swarm optimization algorithm, and collecting images; S5, carrying out distortion correction on the collected images; S6, splicing the distorted and corrected images to obtain a large field of view; and S7, performing super-resolution reconstruction on the region of interest to further improve the resolution of the central fovea region. According to the invention, central fovea imaging with flexible adjustment of the region of interest can be realized, and acquisition of an overall large field of view is considered. Besides, central fovea imaging can be realized only by using the single rotary biprism imaging system, so that the complexity of equipment is greatly reduced, and the method has excellent practical value.

Several new vector-promoter combinations to overcome the limitations associated with AAV-mediated cone transduction in the fovea are provided. The delivery modality relies on a cone-specific promoter and result in high-level transgene expression compatible with optogenetic vision restoration. Methods of expressing a polynucleotide of interest in the cone photoreceptors of a subject comprising subretinal delivery of a therapeutically effective amount of a recombinant AAV9-derived vector comprising a VP1 capsid protein as set forth in SEQ ID NO: 11 and the polynucleotide of interest under the control of the pR1.7 promoter as set forth in SEQ ID NO: 12 are also provided.

Intraocular injection of adeno-associated viral (AAV) vectors has been an evident route for delivering gene drugs into the retina. Currently, the vectors need to be injected into the subretinal spacein order to provide gene delivery to cones. In this approach, gene delivery is limited to cells that contact the local "bleb" of injected fluid. Furthermore, retinal detachment that occurs during subretinal injections is a concern in eyes with retinal degeneration. Here, the inventors establish several new vector-promoter combinations to overcome the limitations associated with AAV-mediated cone transduction in the fovea with supporting studies in mouse models, human induced pluripotent stem cell-derived organoids, post-mortem human retinal explants and living macaques. They show that an AAV9variant provides efficient foveal cone transduction when injected into the subretinal space several millimeters away from the fovea, without detaching this delicate region. The delivery modality relies on a cone-specific promoter and result in high-level transgene expression compatible with optogenetic vision restoration. Accordingly, the present invention relates to method of expressing a polynucleotide of interest in the cone photoreceptors of a subject comprising subretinal delivery of a therapeutically effective amount of a recombinant AAV9-derived vector comprising a VP1 capsid protein asset forth in SEQ ID NO: 11 and the polynucleotide of interest under the control of the pR1.7 promoter as set forth in SEQ ID NO: 12.

The present invention relates to a method (210), a device (110) and a computer program for determining a refractive error of an eye (112) of a user (114). The method (210) for determining the refractive error of the eye (112) of the user (114), wherein the eye (112) of the user (114) has a choroid (124), comprises the following steps: a) determining at least one value for a layer thickness (122) of the choroid (124) of the eye (112) of the user (114) over at least one region (150) of the choroid (124); and b) determining a value (216) for the change in the refractive error of the eye (112) exclusively from at least two values for the layer thickness (122) of the choroid (124), each of which have been determined at different times for the at least one region (150) of the choroid (124), wherein the at least one region (150) is selected from a nasal perifoveal region (168) or a nasal parafoveal region (166).

The invention discloses a bionic visual image target recognition method fusing dot-line memory information, and the method comprises the steps of constructing a grid cell set based on visual drive, constructing a distance cell model, and calculating a displacement vector between the positions coded by a grid cell group vector; calculating the response of all sensory neurons to each central concavepixel k through a Gaussian kernel, wherein the response is used for target recognition; calculating the fovea centralis of the current target image by using Gaussian nuclear sensory cells, taking thefeature tag unit with the strongest response as the next jump point, and accumulating the corresponding stimulated identity cells; selecting a next-hop viewpoint, and updating a foveal displacement vector through a distance cell model; and circularly repeating the calculation of the current position during the target identification process, selecting the next-hop viewpoint, and carrying out the vector calculation until the accumulation of a certain stimulated identity cell reaches a threshold value 0.9, and considering the stimulated identity as the finally identified target. The method provided by the invention has a relatively higher recognition rate for the position change, zooming and shielded images.

Wide angle fovea lens and a camera design using the lens are described. The lens has three lens groups and includes a single aspherical lens element. The lenses have higher magnification on the optical axis than at angles off the optical axis.

Provides neuroprotective therapy for glaucoma, including the generation of micropulsed laser beams with parameters and characteristics, including pulse length, power, and duty cycle, selected to produce a therapeutic effect without visually visible laser lesions or damage to the retina tissue damage. Laser beams are applied to the retinal tissue and / or foveal tissue of eyes with or at risk of glaucoma to produce therapeutic effects on the retinal tissue and / or foveal tissue exposed to the laser beam without destroying or permanently Damage retinal tissue and / or foveal tissue, and improve the function or condition of the optic nerve cells and / or retinal ganglion cells of the eye.