47 results about "Cone cell" patented technology

The invention belongs to the technical field of medicines, and particularly relates to application of Comput-8 in preparation of a product for relieving or treating retina degeneration induced by blue light damage. It is found for the first time that Compond-8 has a protection effect on retina rod cells and cone cells induced by blue light damage, the cilia length, density and membrane disc thickness of the cone cells and the rod cells can be increased, the thickness of a retina outer nuclear layer can be increased, photoreceptor cell damage caused by blue light exposure can be remarkably improved, and the photoreceptor cell damage can be remarkably reduced. The retina degeneration caused by blue light injury can be relieved or treated, and a new thought and means are provided for treatment of the retina degeneration induced by the blue light injury.

According to the spectacle lens design method and the spectacle lens provided by the invention, the surface type basic parameters of the spectacle lens are determined by acquiring the spectacle fitting basic parameters and the eyeball morphological characteristic parameters of a spectacle fitting person, and then the contrast ratio of rod cells is reduced by designing a radial inhibition function, so that the visual burden of the peripheral area of macular is relieved; the surface of the spectacle lens is precisely processed through a laser direct writing technology, a complex microstructure is realized, the precise implementation of a designed radial inhibition function is ensured, and the spectacle lens is further coated through a multi-layer coating technology, so that the transmission ratio of short-wavelength light is increased; the S-cone cells are activated, and the cone cell contrast ratio is reduced, so that the eye axis growth is better regulated and controlled, and the myopia progress is slowed down.

A lighting system and assembly comprising a controller in operable communication with a light unit. The controller is configured to apply a lighting condition using the light unit for a target light color below an upper level of NVIS radiance while controlling a Melanopic-Photopic (M / P) ratio associated with the target light color, and also determine a color mixing for producing NVIS Green A light and NVIS white light for a plurality of levels of NVIS radiance which are less than a maximum NVIS radiance level for a set of M / P ratio values at an upper allowable limit and a set of M / P ratio values at a lower limit.

The utility model relates to the technical field of contact lenses, in particular to a sclera lens with a prevention and control function, which comprises an optical prevention and control area, a middle transition area and an edge landing area. The optical prevention and control area comprises a central area, a vision changing area and a peripheral point diffusion area. The central area is a smooth lens, the variable vision area is arranged on the periphery of the central area and is annular, and the peripheral point diffusion area is arranged on the periphery of the variable vision area and is annular. The vision changing area and the peripheral point diffusion area are both provided with light diffusion points, the atomization effect is achieved, the periphery of the retina is subjected to fuzzy imaging, and the light diffusion points are hole-shaped structural parts. A vision changing area is arranged in an optical prevention and control area, light diffusion points are formed in the vision changing area and a peripheral point diffusion area, light rays are diffused softly through the light diffusion points, the diffused light rays enable the signal difference of adjacent cone cells on the retina to be reduced, meanwhile, an atomization effect is presented, the periphery of the retina is blurred to be imaged, and the retina imaging effect is improved. The purposes of reducing the retina contrast and slowing down myopia growth are achieved.

The application discloses an auxiliary visual light device of mixed light, which mixes the light emitted by different color temperature light emitting units of a mixed light source module, forms a visual effect under the action of the mixed light, and can effectively stimulate the rod cells and cone cells on the retina, which are two kinds of photosensitive visual cells, compared with the prior art, the light intensity of the mixed light can break through to the retina of the eye, and the rod cells and the cone cells respectively dominate dark vision activity and bright vision activity. Therefore, the auxiliary visual light device of mixed light can assist users in visualizing objects, reading books and newspapers, and other visual activities, and provides a new scheme for assisting the human eye to clearly see objects on the level of light technology, in addition to wearing corresponding special glasses to correct, to help solve the problem of unclear vision caused by myopia, hypermetropia, presbyopia and other reasons. Moreover, the wavelength of the light generated by each light emitting unit is greater than 450nm, which can avoid the harm of blue light.

The application discloses a medical goggle lens and a design method thereof, and belongs to the field of goggle lenses. According to the corresponding curves x(lambda), y(lambda) and z(lambda) of three cone cells of a human eye to a visible spectrum, three stimulus values are obtained by using a standard observer response function, the three stimulus values are normalized, the chroma is less than 0.1, the value range of x, y and z is 0.32-0.34, the laser wavelength to be cut off is obtained, the transmittance of other wavelengths is adjusted, corresponding x, y and z design values are obtained, the film system of an optical film is designed according to the x, y and z design values, and the corresponding film system is obtained. Through the above steps, the laser wavelength used in surgery is cut off in a specific wavelength range, the radiation of laser light is prevented from causing harm to the human eye, the transmittance is high, the chromatic aberration is small, the color of the film layer is close to colorless, and the color of the protective lens is reduced to interfere with medical staff.

To allow a minority color vision person to obtain color vision coincident with that of many standard color vision persons by coping with an optical characteristic of a display device and an individual difference in color vision.SOLUTION: A pre-conversion image 100 is displayed on a display 130 for a majority color vision person via a normal display device 120 on one hand, and is displayed on a display 170 for a minority color vision person via a color vision correction device 150 on the other hand. In color vision correction device 150, correction calculator 160 performs correction conversion calculation on the RGB data (R, G, B) according to correction conversion calculation program 162 to obtain corrected RGB data (R ', G ', B '). At this time, the correction conversion is performed so that the cone stimulation values (L, M, S) for a person with polychromatism who views the display 130 and the cone stimulation values (L ', M ', S ') for a person with minority color vision who views the display 170 match.SELECTED DRAWING: Figure 2

The application provides a detection method for the effect of longitudinal chromatic aberration defocus signals on eye refraction development, which comprises the following steps: obtaining a spectral sensitivity function of human eye cone cells; obtaining a first target defocus signal based on the spectral sensitivity function; performing an influence experiment of a display image longitudinal chromatic aberration defocus signal on human eyes based on the spectral sensitivity function, and obtaining a second target defocus signal; performing an animal level in-vivo detection experiment based on the spectral sensitivity function, and obtaining a third target defocus signal; and performing a molecular level analysis experiment of the effect of the image longitudinal chromatic aberration defocus signal on eye refraction development based on the in-vivo detection experiment. The method provided in the embodiments of the application can analyze the effect of DI-LCA defocus signals on refraction development through cone cells from three levels of tissues, animals and molecules, and preferably target defocus signals, thereby providing support for the research and development of display driving programs and devices for reducing the risk of myopia.

This invention discloses the application of the VDAC2 gene or VDAC2 protein as a target in screening drugs for the treatment of retinitis pigmentosa, relating to the field of biomedical technology. The drug is one that reduces the expression level of the VDAC2 gene or inhibits the expression level or activity of the VDAC2 protein; the CDS sequence of the VDAC2 gene is shown in SEQ ID NO.1. This invention uses a rod cell-specific promoter to inhibit VDAC2 expression, which can significantly improve the survival rate of local photoreceptor cells. This method intervenes in the early stages of the disease, conforming to the natural course of RP. It strengthens the function of rod cells before a large number of photoreceptor cells die, delaying their degenerative process and indirectly protecting cone cells, thereby prolonging the patient's effective visual retention time. This overcomes the shortcomings of existing gene therapies, which are mainly applicable to late-stage or specific mutation types, and provides a therapeutic basis for retinitis pigmentosa.

Disclosed herein are synthetic cone-specific promoters. The promoters can be used in nucleic acids, vectors, or host cells to drive expression of a heterologous polypeptide or RNA in retinal cells, particularly cones.

Light-transmitting material with filter properties to provide an environment suited to the visual characteristics of the user In addition, it is possible to provide a filter having filter characteristics that take into account the characteristics of human cone cells. It is possible to provide a light transmitting material. The light transmitting material is a light transmitting material coated with a coating agent having a predetermined filter characteristic. A filter material, the predetermined filter characteristics being a transmittance of 60% in the range of 400 to 480 nm. and a relationship between the predetermined filter characteristic and the absorption spectrum of human blue cone cells of 40 The convolution integral in the wavelength range of 0 to 480 nm is the standard filter characteristic with a transmittance of 100%. The characteristic of being cut by 40% or more from the convolution integral of the relevant absorption spectrum in the relevant wavelength band. It is sexuality.

The application discloses a multifunctional visual acuity prevention and control wearable device based on a sound wave factor, which comprises an eye protection frame body and an adjustable elastic band connected with the eye protection frame body; a control module and a power module are arranged in the eye protection frame body; a plurality of sound wave resonance generators corresponding to the acupoints of the human eyes are arranged outside the eye protection frame body; the power module is electrically connected with the control module and the sound wave resonance generators respectively. The application further comprises a connection sensing and feedback unit and a frequency regulator connected with the control module. The application discloses a use method of the multifunctional visual acuity prevention and control wearable device based on the sound wave factor. Based on the physical characteristics and biological effects of the sound wave resonance and the resonance effect of the sound wave factor, a series of biological effects are generated on the biological cells and tissues of the acupoints around the human eyes, so that the gene expression of the eye tissues is influenced, the sensitivity of the cone cells and the secretion of dopamine are promoted, the visual recognition ability is optimized, the growth of the eye axis is inhibited, and the prevention and control of the naked eye myopia are achieved.

In the display panel and the display device, red sub-pixels and blue sub-pixels with the number ratio of 2: 1 are connected through first scanning lines, due to the fact that the near-end feed-through effect is large, green sub-pixels and blue sub-pixels with the number ratio of 2: 1 are connected through second scanning lines, and due to the fact that the far-end feed-through effect is small, the near-end feed-through effect is large. Therefore, the display area close to one side of the first gate drive circuit is bright in green and dark in red, and the whole left side is turquoise. Therefore, the display area close to one side of the second gate drive circuit is dark red and bright green, and the right side of the display area is pink as a whole. In the whole visual effect, the display area close to one side of the second gate drive circuit is slightly pink, and the whole visual color cast of the display area is improved when people watch the display area with the eyes based on the characteristics that the human eyes have relatively many yellow-green perception cone cells, are sensitive to yellow-green light and are not sensitive to red-blue light.

This invention provides a light source with high chromatic color richness. The high chromatic color richness light source is based on the difference in stimulation patterns of the three types of cone cells in the human eye's color perception mechanism between monochromatic light and mixed light that can be identified as that color. The visible light band from 380nm to 780nm is divided into three bands using 430nm and 680nm as sub-band wavelength values. Furthermore, it is designed based on the emission peak wavelength of LED chips and phosphors using the corresponding LED chips as excitation sources, ensuring the richness of the emission peak wavelengths of the high chromatic color richness light source in each band, thus guaranteeing the chromatic color richness of the light source. Therefore, it is beneficial in the human eye's color perception mechanism to make the chromatic color of the object being observed more similar to that of the observed object, thereby improving the human eye's ability to compare and filter differences in the observed object and providing a natural, realistic, and comfortable visual experience.

This invention discloses the application of disodium 4,4'-diisothiocyanate-2,2'-stilbene sulfonate in the preparation of drugs for the prevention, delay, and / or treatment of blue light-induced retinal damage. It belongs to the field of biomedical technology. This invention demonstrates for the first time that sodium DIDS can effectively protect photoreceptor cells from blue light damage: at the cellular level, sodium DIDS can restore mitochondrial membrane potential, increase ATP levels, reduce reactive oxygen species accumulation, and inhibit mitochondrial-dependent apoptosis; at the animal level, intravitreal injection of sodium DIDS can improve vision in mice exposed to blue light, restore the amplitude of a-waves and / or b-waves in electroretinograms, and protect the outer segment length and outer nuclear layer thickness of cone cells. Sodium DIDS provides a novel therapeutic strategy for blue light-induced retinal photodamage through multi-target synergistic protection of mitochondrial function.

The invention relates to the field of intelligent medical treatment, in particular to an eye disease prediction method and device based on monochromatic light and a program product. Comprising obtaining a monochromatic background light source; the monochromatic background light source flickers at a frequency to perceive the retina of the subject to obtain perceived data; performing eye disease judgment based on the sensing data of the monochromatic light source, when the background light source is red and the sensing data is smaller than a red preset threshold value, predicting that the visual cone cells in the macular region are abnormal, otherwise, predicting that the visual cone cells are normal; when the background light source is green and the sensing data is smaller than a green preset threshold value, determining that the optic nerve conduction of the vertebral body is abnormal, otherwise, determining that the optic nerve conduction is normal; and when the background light source is a yellow light source and the sensing data is smaller than a yellow preset threshold, judging that the retina and the optic nerve are abnormal, otherwise, judging that the retina and the optic nerve are normal. Eye anomaly prediction can be carried out through the monochromatic light source, and the method has good clinical value.

Lighting devices, systems, and methods for selectively activating S cones and L+M cones in a human retina and for regulating the phase of circadian rhythm in a human subject.

The present invention relates to a nucleic acid having promoter activity in cone cells. The invention also relates to an expression cassette or vector comprising the promoter, a viral particle or cell comprising the expression cassette or vector, and a pharmaceutical composition comprising the expression cassette or vector and the viral particle or cell. The invention also relates to the use of said expression cassette, vector, viral particle, cell or pharmaceutical composition in the treatment of eye diseases, in particular hereditary retinal diseases.

The invention discloses a visual interaction method for splicing processors, and relates to the technical field of man-machine interaction, and the method comprises the steps: tracking a user iris motion track in real time, determining a processor in a current view cone focus region, and marking a processor in a non-focus region outside the view cone focus region; when the node position similarity exceeds a preset verification threshold value, triggering a configuration change command corresponding to execution of the prediction instruction to a marked non-focus area processor; new load data generated by the configuration change command after execution are collected in real time, whether the new load data exceed the preset load threshold value or not is judged again, and a dynamic monitoring and interactive closed loop is formed. According to the method, the pulse spectrum is projected to the peripheral visual field of the retina of a user, a non-intrusive optical signal is formed in the peripheral visual field of the retina by using the infrared spectrum, and the load alarm is transmitted on the premise of not interfering central focus processing of cone cells by using the high sensitivity of the rod cells to a dynamic light source.

The present invention discloses an infrared light-emitting module and a preparation method thereof. The module includes a glue iron. A reflective film, a light guide plate, a diffusion film, a lower brightness enhancement film, and an upper brightness enhancement film are sequentially installed in the assembly groove of the glue iron from bottom to top. An infrared LED point light source with a wavelength of 600 nm to 750 nm is provided between one side of the light guide plate, the reflective film, and the diffusion film. The infrared LED point light source includes a substrate layer, a Bragg optical reflection layer, an N-type confinement layer, an active layer, a P-type confinement layer, and a window layer. The infrared wave emitted by the infrared light-emitting module of the present invention has a stimulating and activating effect on the cone cells in the retina of the human eye, thereby helping with eye training. By setting side point light sources, the light-emitting angle is larger. And through the setting angle cooperation of the upper and lower brightness enhancement films, infrared light perpendicular to the human eye direction can be generated, avoiding light spillage, making it more concentrated and more direct in stimulating and activating the cone cells of the eye retina, and helping the eyes recover visual health.

The invention discloses multifunctional vision prevention and control wearable equipment based on sound wave factors. The multifunctional vision prevention and control wearable equipment comprises an eye protection frame body and an adjustable elastic band connected with the eye protection frame body in a matched mode. A control module and a power supply module are arranged in the eye protection frame body; a plurality of sound wave resonance generators corresponding to human eye acupoints are arranged outside the eye protection frame, and the power module is electrically connected with the control module and the sound wave resonance generators. The sensing and feedback unit and the frequency regulator are connected with the control module. The invention discloses a use method of multifunctional vision prevention and control wearable equipment based on sound wave factors. Based on physical characteristics and biological effects of sound wave resonance, in combination with resonance effects of sound wave factors, a series of biological effects are generated on biological cells and tissues of acupuncture points around eyes of a human body, so that gene expression of eye tissues is influenced, cone cell sensitivity and dopamine secretion are promoted, visual recognition capability is optimized, and eye axis growth is inhibited; the prevention and control of the naked eye myopia are realized.

The application relates to a fishery lighting LED light source, which comprises a support, a first blue light LED chip, a second blue light LED chip, a bonding wire and fluorescent glue, a bowl cup is arranged on the support; the first blue light LED chip and the second blue light LED chip are arranged at the bottom of the bowl cup and are connected in series, wherein the first blue light LED chip is connected with a conductive part one through the bonding wire, and the second blue light LED chip is connected with a conductive part two through the bonding wire; the bowl cup is filled with the fluorescent glue, the fluorescent glue covers the whole functional area, the first blue light LED chip, the second blue light LED chip and all the bonding wires; the fluorescent glue comprises silicon A glue, silicon B glue, green fluorescent powder, yellow-green fluorescent powder and red fluorescent powder; the fishery lighting LED light source is prepared through the blue light chip and specific fluorescent powder, a double-wave-peak spectrum with good continuity is formed, the peak spectrum band has high sensitivity to the cone cells of marine fishes, has strong penetration in seawater and has good gathering effect on the marine fishes.

The utility model discloses a point diffusion prism lens composite lens, which relates to the technical field of myopic glasses, and comprises a point diffusion lens and a second lens arranged on the inner side or the outer side of the point diffusion lens, and the second lens is selected from one of a combined prism lens, a progressive lens or a defocus lens. The combined prism lens is formed by combining a prism and a convex lens, and the convex lens is located between the prism and the point diffusion lens. The combined prism lens is wedge-shaped, the thicker end of the combined prism lens is a base, and the thinner end of the combined prism lens is a base top. According to the point diffusion prism lens composite lens, the point diffusion lens is respectively compounded with the combined prism lens, the progressive lens or the out-of-focus lens, so that incident light is scattered, soft optical transition is formed in a peripheral view field, and the design reduces the signal intensity difference between adjacent view cone cells, namely, reduces the contrast ratio; therefore, 'elongation signals' transmitted from the retina to the eyeball are inhibited, and eye axis growth is slowed down.

The invention generally relates to a color vision test using pseudo-isochromatic plates to test color deficiency. The pseudo-isochromatic plates of the color vision test having a targeted cone class of the human eye (S-cone, M-cone, or L-cone) and incorporating chromatic noise.

The present invention relates to a TAFA protein, a fragment thereof, or a variant thereof, which has the ability to increase the length or branching point of neurites. In addition, the present invention relates to a therapeutic use of a pharmaceutical composition containing: a polypeptide comprising the amino acid sequence of the TAFA protein, a fragment thereof, or a variant thereof; a nucleic acid molecule encoding the polypeptide; a vector carrying the nucleic acid molecule; a recombinant viral particle comprising the vector and a capsid protein; a cell comprising the vector; a cell transformed with the vector; or a combination thereof. The composition of the present invention promotes recovery from damaged retinas (for example, cone cells of photoreceptors, etc.) or increases the length of neurites in neurons, and thus can be advantageously used for preventing or treating retinal neurological diseases and / or neuropathic pain.

According to the individualized color vision abnormality image color reconstruction method based on the physiological model, continuous offset of an L / M visual cone absorption peak value is simulated on the wave number scale, spectral perception changes of color weakness / color blindness people on the physiological structure level are truly represented, and scientificity and interpretation of color vision abnormality simulation are remarkably improved; a color vision anomaly model for individuals is constructed, so that a simulation result not only conforms to a physiological mechanism, but also can reflect unique color vision features of each observer, and technical support is provided for individualized image enhancement and accurate visual evaluation; eEW normalization correction is carried out on abnormal cone cell response, so that the visual response of a simulated individual under isoenergetic white light is consistent with that of a standard observer, and the stability and naturalness of image simulation are facilitated; the GOG model is introduced in the mapping process between the RGB space and the XYZ space, Gamma response characteristics and channel nonlinearity of actual display equipment are fully considered, and the fitting precision from image pixels to visual response is effectively improved.

A pharmaceutical composition for treating an eye disease and a method. A nucleic acid construct, comprising a cone cell specific promoter and a coding sequence for a CRX protein. The pharmaceutical composition can delay the death of cone cells in retinitis pigmentosa, and prolong patients' daytime visual function, and can be used for treating retinal degenerative diseases.

This correction filter changes the spectrum of light transmitted therethrough, and changes the spectrum of light in a wavelength band including at least one of an absorption maximum wavelength [lambda] L that peaks in the absorption spectrum of human L-cone cells and an absorption maximum wavelength [lambda] M that peaks in the absorption spectrum of human M-cone cells. The correction filter is set so that the transmittance increases from a wavelength XC between lambda L and lambda M to a wavelength XL longer than the wavelength of lambda L when changing the spectrum of light in a wavelength band including lambda L, and is set so that the transmittance increases from the wavelength XC to a wavelength XS2 shorter than the wavelength of lambda M when changing the spectrum of light in a wavelength band including lambda M.

A device for optical-field displaying includes: a display screen and a lens unit provided on a light exiting side of the display screen; the lens unit includes a plurality of lenses arranged in an array; the display screen is provided on a focal plane of the plurality of lenses; the display screen includes a first substrate and a second substrate that match; the first substrate is a light-exiting-side substrate, the second substrate includes a plurality of pixel islands arranged in an array; the plurality of pixel islands correspond to the plurality of lenses; a view region formed by light rays emitted by the sub-pixels of the pixel islands and propagated via the corresponding lenses to a human eye is smaller than or equal to a half-pupil region, and light rays of different viewpoints emitted by different sub-pixels of the pixel islands enter different cone cells via the lenses.

To provide a light transmission material having a filter property which offers an environment suitable for a visual property of a user and which takes into account a property of a human cone cell.SOLUTION: A coating agent with a predetermined filter property is applied to a light transmission material. The predetermined filter property has a transmittance of less than 60% in a range between 400 nm and 480 nm. A convolution integral of the predetermined filter property and an absorption spectrum of a human blue core cell in a wavelength range between 400 nm and 480 nm is obtained by cutting a convolution integral of a reference filter property with a transmittance of 100% and the absorption spectrum in the wavelength range by 40% or more.SELECTED DRAWING: Figure 4B