The utility model discloses a picture frame with a picture core capable of being replaced when being hung on a wall surface and attractive in overall side surface. The picture frame comprises an outer frame, a picture core baffle, an inner frame group and a connecting piece, the picture core baffle is fixed in an inner cavity of the outer frame in a matched mode. The inner frame set comprises a base plate seat, in the initial state, the base plate seat is embedded in an inner cavity of the outer frame, the overall attractiveness of the side face of the picture frame is kept, and the picture core is arranged on the surface of the base plate seat. The connecting piece is a long-short-edge hinge, the long edge of the hinge is connected with the back face of the inner frame set in a matched mode, the short edge of the hinge is connected with a frame strip on the back face of the outer frame in a matched mode, and when the inner frame set is fixed to a wall, the outer frame can be opened without barriers for picture core replacement operation through the characteristics of the long edge and the short edge of the long-short-edge hinge. Meanwhile, the substrate seat fixed on the bottom plate is divided into the blocking panel and the line frame. Wherein the blocking panel and the line frame are detachably fixed. A user can arrange a plane picture core on the blocking panel according to requirements, or take down the blocking panel and arrange a three-dimensional piece in the line frame for display.