A marker for detection or auxiliary detection of retinal cone cells and application thereof

A technology of cone cells and retina, applied in the field of biomedicine, can solve problems such as the inability to apply animal models or cell model identification
CN112063719BActive Publication Date: 2022-01-14INST OF ZOOLOGY CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF ZOOLOGY CHINESE ACAD OF SCI
Publication Date
2022-01-14

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Abstract

The invention discloses a marker for detecting or assisting in detecting retinal cone cells and an application thereof. The present invention provides the application of a substance for detecting whether the RBP4 protein is expressed in the sample to be tested in at least one of the following: a1) identification or auxiliary identification of retinal cone cells; a2) screening or auxiliary screening of retinal cone cells; a3) evaluation or Auxiliary evaluation of retinal cone cells; a4) identification or auxiliary identification of whether the sample to be tested contains retinal cone cells; a5) screening or auxiliary screening of whether the sample to be tested contains retinal cone cells; a6) evaluation or auxiliary evaluation of whether the sample to be tested contains Retinal cone cells; the present invention finds that RBP4 can be used as a marker to identify or assist in the identification of retinal cone cells by constructing and analyzing a cynomolgus monkey retinal cone cell sequencing library and immunofluorescence detection. The above markers can be used to evaluate retinal aging-related diseases such as macular degeneration and retinitis pigmentosa. The invention has important application value.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and in particular relates to a marker for detecting or assisting in detecting retinal cone cells and an application thereof. Background technique

[0002] As a soft and transparent membrane attached to the inner surface of the choroid, the retina can sense light stimulation and convert it into nerve impulses, which are transmitted to the visual center of the cerebral cortex to form vision. The main retinal photoreceptors, including rods and cones. Degeneration of the retina may lead to visual damage and loss of vision. Therefore, in-depth analysis of retinal cell types and cell-specific molecular markers, and the search for retinal cell markers and retinal cell aging markers will provide important molecular indicators for the research and intervention of retinal development and retinal aging-related diseases.

[0003] The degeneration of retinal photoreceptor cells such as cone cells is closely relat...

Claims

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