40 results about "Retinal Cones" patented technology

The invention provides a human visual perception simulation-based self-adaptive low-illumination image enhancement method. The method is put forwards based on characteristics of low brightness and low contrast of a low-illumination color image and through researching an automatic adjustment process of pupils and photoreceptor cells for an environment. The method includes the following steps that: the adjustment process of the pupils for light is simulated, and the total brightness level of the image is improved; and the self-adaptive adjustment and control ability of eye vision for a low-illumination environment is simulated, and a nonlinear mapping model is designed to simulate the adjustment process of rod cells and cone cells, so that a bright and dark self-adaptation function can be obtained, and a bright and dark information fusing function is determined according to illumination distribution, and global self-adaptive adjustment is performed on brightness components; and the local contrast of the enhanced brightness image will be decreased, so that local self-adaptive contrast enforcement is performed on the image through adopting an exponential function; and finally, and color restoration is performed on the enhanced image. With the human visual perception simulation-based self-adaptive low-illumination image enhancement method of the invention adopted, the brightness, local contrast and detail information of the low-illumination color image can be effectively improved, and especially, the method has obvious effects in dark area and highlight area enhancement.

Isolated, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin− HSCs) contain endothelial progenitor cells (EPCs) capable of rescuing retinal blood vessels and neuronal networks in the eye. Preferably at least about 20% of the cells in the isolated Lin− HSCs express the cell surface antigen CD31. The isolated Lin− HSC populations are useful for treatment of ocular vascular diseases and to ameliorate cone cell degeneration in the retina. In a preferred embodiment, the Lin− HSCs are isolated by extracting bone marrow from an adult mammal; separating a plurality of monocytes from the bone marrow; labeling the monocytes with biotin-conjugated lineage panel antibodies to one or more lineage surface antigens; removing of monocytes that are positive for the lineage surface antigens from the plurality of monocytes, and recovering a Lin− HSC population containing EPCs. The isolated Lin− HSCs also can be transfected with therapeutically useful genes. The treatment may be enhanced by stimulating proliferation of activated astrocytes in the retina using a laser.

The invention relates to a cone-cell density calculation method based on image identification. The method mainly solves the prior problem that density counting of cone cells is performed manually and an eye-ground adaptive confocal laser scanning ophthalmoscope is used to obtain a visual cone-cell image and after the response frequency of the cone cells is determined, low-pass filtering is used for denoising processing so as to establish a two-valued sequence. A local maximum value corresponding to a non-zero area is searched for so that the central position of the cone cells is found. After automatic identification of the visual cone cells in the image is completed, the number of the cone cells in the image is obtained with the assistance of manual correction and finally the density counting of the cone cells is achieved. When the function which adopts a computer to counting automatically is compared with a manual counting method, the automatic calculation method is accurate, high in statistical speed, high in automation degree, checkable in analysis result and improved in detection efficiency. At the same time, a manual correction function is added so that on the basis of software analysis, error identification can be removed manually and missed cone cells can be added and thus caused result deviation is prevented.

Methods and compositions are provided for intravitreally delivering a polynucleotide to cone photoreceptors. Aspects of the methods include injecting a recombinant adeno-associated virus comprising a polynucleotide of interest into the vitreous of the eye. These methods and compositions find particular use in treating ocular disorders associated with cone dysfunction and / or death.

The invention relates to filter dedicated to protect eye cone cells and method associated. The eye cone cells protecting filter is intended to be applied to a transparent surface and to filter incident light for preventing eye cone cells of a user, from damages due to illumination at physiological light levels on the eye of said user, and having spectral characteristics to i) filter light wavelengths between 405 and 465 nanometers, and ii) transmit a filtered light reaching the eye cone cells and having a harmfulness on said eye cone cells under a predefined maximum threshold.