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Reagents and methods for modulating cone photoreceptor activity

a technology of cone photoreceptors and receptors, applied in the field of cone cell gene therapy, can solve the problems of ineffective treatment of congenital vision disorders, inability to appropriately process inputs that were not present at birth, and inability to properly process inputs established during development. to achieve the effect of restoring visual capacity

Inactive Publication Date: 2012-07-05
MCW RES FOUND INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]The method of this aspect of the invention can be used, for example, to treat a cone cell disorder, including but not limited to color blindness, blue cone monochomacy, achromatopsia, incomplete achromatopsia, rod-cone degeneration, retinitis pigmentosa (RP), macular degeneration, cone dystrophy, blindness, Stargardt's Disease, and Leber's congenital amaurosis. In one embodiment, the methods restore visual capacity in the primate; in another embodiment, the primate is able to visualize new colors as a result of the therapy. In another embodiment, the primate has a vision disorder in which its photoreceptors are healthy. In a further embodiment, the primate is an adult primate.

Problems solved by technology

Classic visual deprivation experiments have led to the expectation that neural connections established during development would not appropriately process an input that was not present from birth.
Therefore, it was believed that treatment of congenital vision disorders would be ineffective unless administered to the very young.

Method used

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  • Reagents and methods for modulating cone photoreceptor activity
  • Reagents and methods for modulating cone photoreceptor activity
  • Reagents and methods for modulating cone photoreceptor activity

Examples

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example 1

REFERENCE FOR EXAMPLE 1

[0148]1. Wiesel, T. N. & Hubel, D. H. Single-cell responses in striate cortex of kittens deprived of vision in one eye. J. Neurophysiol. 26, 1003-1017 (1963).[0149]2. Jacobs, G. H. A perspective on color vision in platyrrhine monkeys. Vision Res. 38, 3307-3313 (1998).[0150]3. Li, Q., Timmers, A. M., Guy, J., Pang, J. & Hauswirth, W. W. Cone-specific expression using a human red opsin promoter in recombinant AAV. Vision Res. 48(2007).[0151]4. Reffin, J. P., Astell, S. & Mollon, J. D. Trials of a computer-controlled colour vision test that preserves the advantages of pseudo-isochromatic plates. in Colour Vision Deficiencies X69-76 (Kluwer Academic Publishers, Dordrecht, 1991).[0152]5. Regan, B. C., Reffin, J. P. & Mollon, J. D. Luminance noise and the rapid determination of discrimination ellipses in colour deficiency. Vision Res. 34, 1279-1299 (1994).[0153]6. Mancuso, K., Neitz, M. & Neitz, J. An adaptation of the Cambridge Colour Test for use with animals. Vis...

example 2

REFERENCES FOR EXAMPLE 2

[0190]Sutter, E. E. (1991). The Fast m-Transform: A Fast Computation of Cross-Correlations with Binary m-Sequences. SIAM Journal on Computing, 20(4), 686-694.[0191]Swanson, W. H., Ueno, T., Smith, V. C., & Pokorny, J. (1987). Temporal modulation sensitivity and pulse-detection thresholds for chromatic and luminance perturbations. Journal of the Optical Society of America A—Optics, Image Science and Vision, 4(10), 13.[0192]Lindenberg, T., Horn, F. K., & Korth, M. (2003). Cyclic summation versus m-sequence technique in the multifocal ERG. Graefes Archive of Clinical Experimental Ophthalmology., 241(6), 505-510.

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Abstract

The present invention provides reagents and methods for modulating cone photoreceptor activity, and devices for assessment of cone photoreceptor activity.

Description

RELATED APPLICATIONS [0001]This application claims priority to U.S. Provisional Patent Application Ser. No. 61 / 242587 filed Sep. 15, 2009, incorporated by reference herein in its entirety.STATEMENT OF U.S. GOVERNMENT SUPPORT [0002]This work was supported by the National Institutes of Health grants R01EY016861, R01EY11123, and P30EY01730. The U.S. government has certain rights in the invention.BACKGROUND [0003]Classic visual deprivation experiments have led to the expectation that neural connections established during development would not appropriately process an input that was not present from birth. Therefore, it was believed that treatment of congenital vision disorders would be ineffective unless administered to the very young.SUMMARY OF THE INVENTION[0004]In a first aspect, the present invention provides methods for cone cell gene therapy in a primate, comprising administering to the eye of a primate in need of cone cell gene therapy a recombinant gene delivery vector comprisin...

Claims

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Application Information

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IPC IPC(8): A61K48/00A61B5/04C12N5/10A61P27/02C12N15/85C12N15/861
CPCA61B5/0496A61B5/7225A61K48/0075C12N2799/025C12N2830/008C12N2830/42C12N2840/44A61N2005/0663A61N2005/0661A61N2005/0652A61N5/0622C12N15/85A61B5/6821A61B5/4848A61B5/4836A61K48/0058A61P27/02A61B5/0036A61B5/398A61B5/0048C07K14/005C12N7/00C12N15/86C12N2750/14132C12N2750/14143
Inventor NEITZ, JAYNEITZ, MAUREENKUCHENBECKER, JAMES A.
Owner MCW RES FOUND INC
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