The invention provides an aluminum-vanadium-niobium intermediate alloy, an aluminum-vanadium-niobium-titanium intermediate alloy and preparation methods of the aluminum-vanadium-niobium intermediate alloy and the aluminum-vanadium-niobium-titanium intermediate alloy, and belongs to the field of metal materials. The invention provides the aluminum-vanadium-niobium intermediate alloy and the aluminum-vanadium-niobium-titanium intermediate alloy. Aluminum is the most important strengthening element in titanium alloy, has a remarkable solid solution strengthening effect and can remarkably improve the high-temperature mechanical performance of the titanium alloy, and meanwhile, the aluminum also has a relatively low density and is beneficial for improving the specific strength of the titanium alloy; vanadium has the effect of strengthening the titanium alloy, and when a certain proportion of vanadium is added into the titanium alloy, the alloy has good ductility, corrosion resistance, formability and other excellent performance. Niobium can be subjected to infinite solid solution in beta titanium, the solid solution strengthening effect is achieved, when the alloy strength is improved, the thermal stability of the alloy can also be effectively improved, and good plasticity is maintained. According to the invention, by controlling components and content, the aluminum-vanadium-niobium and aluminum-vanadium-niobium-titanium intermediate alloys are uniform in component and small in segregation, and during titanium alloy smelting, titanium alloy component homogenization is facilitated, and component segregation is prevented.