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Compositions comprising MG29 nucleic acids, polypeptides and associated methods of use

A technology for polypeptides and nucleic acid molecules, applied in the field of recombinant nucleic acids and polypeptide compositions, can solve problems such as synaptic plasticity defects

Active Publication Date: 2015-07-15
RUTGERS THE STATE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Indeed, mice deficient in both synaptophysin and synaptogyrin showed defects in synaptic plasticity

Method used

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  • Compositions comprising MG29 nucleic acids, polypeptides and associated methods of use
  • Compositions comprising MG29 nucleic acids, polypeptides and associated methods of use
  • Compositions comprising MG29 nucleic acids, polypeptides and associated methods of use

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Embodiment Construction

[0039] Described now are compositions and methods related to the surprising and unexpected discovery that MG29 is an important structural and functional component in the excitation-contraction (E-C) coupling process that controls muscle function and plasticity.

[0040] The following U.S. Provisional Patent Applications: Serial No. 61 / 135,325, filed July 18, 2008, entitled "MG29 and Muscle Function in Stress and Disease"; and April 8, 2009, entitled "Compositions Comprising MG29 Nucleic Acids, Polypeptides and Associated Methods of Use, Ser. No. 61 / 212,275, which is hereby incorporated by reference in its entirety for all purposes.

[0041] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. All publications, patent applications, patents, and other references mentioned herein are hereby incorporated by reference in their entirety. In case of d...

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PUM

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Abstract

Disclosed herein are compositions and methods for treatment of muscle dysfunction (including sarcopenia) and other diseases involving skeletal muscle, including age-related muscle dysfunction. In addition, the invention relates to therapeutic compositions comprising nucleotides and / or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the treatment of skeletal muscle disorder, including those related to thr normal aging process. Moreover, the invention relates to the treatment and / or prevention of pathological conditions associated with altered intracellular Ca2+ regulation and disrupted membrane structure that occurs when the expression levels of MG29 are reduced.

Description

[0001] References to related applications [0002] Pursuant to 35 U.S.C. §119(e), this application claims priority to the following U.S. Provisional Patent Application: Serial No. 61 / 135,325, filed July 18, 2008, entitled "MG29 and Muscle Function in Stress and Disease"; and Serial No. 61 / 212,275, entitled "Compositions Comprising MG29 Nucleic Acids, Polypeptides and Associated Methods of Use," filed April 8, 2009, is hereby incorporated by reference in its entirety for all purposes. [0003] citation [0004] According to 37C.F.R. §1.52(e)(5), the electronic CRF of the sequence listing is submitted with this article: file name: MG29_seqlist_ST25.txt; size: 67KB; created on July 14, 2009; using PatentIn-3.5, Checker 4.4 .0 is hereby incorporated by reference in its entirety. The data in computer readable form of the accompanying Sequence Listing, containing no novelty, is fully supported by priority applications US Provisional Patent Application Nos. 61 / 135,325 and 61 / 212,275....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K48/00A61K38/17A61P21/00
CPCA61K38/00C12Q1/6883A61K38/1709C12N15/8509C12N2800/30C12Q2600/136A01K2267/03C12Q2600/158A01K2217/058A01K2217/203A61K35/34C12Q2600/156A01K2227/105C12N2840/20A01K2217/206A01K67/0275C07K14/705A61P21/00
Inventor 麻建杰诺厄·魏斯勒德
Owner RUTGERS THE STATE UNIV
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