53results about How to "Reduce miscarriage rate" patented technology

Methods and compositions for regulating immunity are disclosed. For enhancing an immune response, agents that inhibit OX-2 are administered. Such methods are useful in treating cancer. For suppressing an immune response, an OX-2 protein or a nucleic acid encoding an OX-2 protein is administered. Such methods are useful in preventing graft rejection, fetal loss, autoimmune disease, allergies and in inducing tumor cell growth.

The invention provides a protocol leading to improved embryo implantation rates and / or decreased miscarriage rates in which hCG, or a bio-analogue, is administered during the follicular phase.

The invention provides a protocol leading to improved embryo implantation rates and / or decreased miscarriage rates in which hCG or LH, or a bio-analogue thereof, is administered during the follicular phase.

Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of a CD200 protein or a nucleic acid encoding a CD200 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune disease, and allergies. Methods and compositions for preventing immune suppression are also disclosed. The methods involve administering an effective amount of an agent that inhibits CD200. Such methods are useful in treating cancer.

A profertility composition for administration to infertile men with sperm oxidative stress is disclosed. The composition comprises a unique combination of a pharmaceutically acceptable vitamin E, vitamin C, selenium, zinc, folic acid, lycopene and at least one carnitine source.

The invention discloses a semen nourishing capsule for treating male sexual dysfunction and the preparation method thereof. The semen nourishing capsule is made from prepared rehmannia root, epimedium herb, Chinese angelica root, lychee seed, raw milkvetch root, rhizoma polygonati, leech, human placemta, flatstem astragalus seed, calcined oyster shell and seed of cowherb in definite weight proportions. The preparation method comprises the following steps: (1) volatile oil is extracted from the Chinese angelica root; (2) a reflux extraction is applied to the epimedium herb and lychee seed by ethanol to obtain an ethanol extract; (3) the residues obtained from StepS (1) and (2) are mixed with the dried leech, siberian solomonseal rhizome, raw milkvetch root, calcined oyster shell, flatstem astragalus seed, prepared rehmannia root and seed of cowherb according to the formula, and then the mixture is extracted by water to obtain an aqueous extract; (4) dried human placemta is crushed into superfine powder; (5) the volatile oil obtained from the step (1) is included by Beta-CD; (6) the ethanol extract, the aqueous extract, the dried human placemta superfine powder and the beta-CD inclusion obtained in Steps (1), (2), (3), (4) and (5) are evenly mixed and dried by spraying to obtain the extracturm; the extracturm is added with adjuvants for dry granulation; the granules are capsulated and packaged to obtain the semen nourishing capsules. The semen nourishing capsule has the advantages of mild temperament, reinforcing yin and yang reinforcements, and excretion promotion of the seminal vesicle fluid, thus arousing the sexual desire and erection.

A method of improving cumulative embryo score may comprise administering an androgen to a human female for at least about four consecutive months followed by harvesting and fertilizing oocytes and forming embryos. A method of increasing the quantity of fertilized oocytes in one cycle of in vitro fertilization may comprise administering an androgen to a human female for at least about four consecutive months, harvesting and fertilizing the oocytes. A method of normalizing ovarian DHEA may include administering an androgen for at least about four consecutive months. A method of decreasing the time to pregnancy and increasing the rate of pregnancy by administering an androgen for at least about two months. A method of decreasing miscarriage rates may comprise administering an androgen for at least about two months to a female. Moreover, a method of decreasing aneuploidy rates in human embryos may comprise administering an androgen to a female for at least about two months.

The invention provides a method for breeding experimental macaca mulatta. The mode of female money single-cage raising and regular mating is adopted in the mating period, the mode that infant monkeys and a female monkey are raised in a concentrated mode in the lactation period and an adult male monkey is isolated is adopted, the monkey group fighting problem is effectively solved, the infant monkeys are raised in a single-breeding monkey cage in the ablactation period, the breeding quality is further improved, and the health condition of the macaca mulatta can be discovered and managed in time. The breeding rate and the pregnancy rate of the macaca mulatta are further improved, the phenomenon that the female monkey of the right age is infertile in the breeding period is greatly reduced, the oestrus, mating and farrowing activities of personal macaca mulatta can be observed conveniently, and the health condition of the macaca mulatta can be discovered and managed in time. According to the method, overall comprehensive breeding management is combined with rich and reasonable breeding equipment, and thus the yield and the quality of the experimental macaca mulatta are greatly improved.

The invention discloses a dietary fiber feed for sows at a pregnancy period, and relates to the field of animal feeds. The feed consists of 100-200 parts of wheat bran, 2-5 parts of inulin, 10-50 parts of beet pulp, 150-200 parts of wheat, 100-200 parts of oat, 100-200 parts of barley, 50-100 parts of soybean meal, 10-20 parts of fish meal, 10-15 parts of soybean oil, 5-10 parts of palm oil, 5-20parts of brown sugar, 0.5-0.8 part of bacillus subtilis, 0.2-0.3 part of saccharomyces cerevisia, 0.2-0.3 part of enterococcus faecalis and 0.1-0.2 part of rhodop seudanonas palustris. The feed for sows at the pregnancy period can provide sufficient satiety, so that the sows can be quiet and the abortion rate is reduced; normal intestinal peristalsis of the sows can be guaranteed, the problem of constipation of the sows can be solved, the health of the sows can be promoted, and rate of the healthy piglets is increased; the epigaster of the sows is developed in functions, the dietary fiber ration can promote the microbial fermentation action of the epigaster, can maintain the normal region of enteric microorganisms of the sows, can guarantee the establishment of enteric microorganisms of new-born piggies, and can promote health of intestinal tracts of suckling pigs; the utilization rate of nutrient substances is increased, massive volatile fatty acids are generated, sow inflammation problem and hoof problems can be solved, the childbirth is shortened, and the using period of the sows is prolonged.

The invention discloses a method for improving the test-tube baby clinical outcome by selecting an embryo with good development potential. The method comprises five steps that the transplanting embryo with good development potential is selected mainly according to IL-8 in an embryo culture solution before the transplanting; concretely, a liquid phase chip high-flux protein analysis technology is used for detecting the content of IL-8 in a sample; an IL-8 positive embryo in the culture solution is selected to be combined with a morphology evaluation method to perform transplantation; the IL-8 positive embryo in the culture solution before the transplantation is used for being combined with the morphological high-quality embryo to perform transplantation; the pregnancy rate can be improved by more than 8 percent, and can reach 60.76 percent; compared with the existing transplantation method for selecting the embryo singly by a morphology method, the method provided by the invention has the advantages that the pregnancy rate can be improved by more than 8 percent to 12 percent. When the method is combined with the existing morphology method for selecting high-quality embryo; or the high-quality embryo and the ordinary embryo are transplanted to an in vitro fertilization person, the embryo planting rate can also be improved; the baby live birth number is increased; the patient clinic pregnancy rate is improved; the abortion rate is reduced.

The invention relates to a feed for pigs, in particular to an antibiotic-free compound feed for French sows at a gestation period. The feed comprises the following components in parts by weight: 200-250 parts of corn, 450-500 parts of barley, 100-150 parts of soybean meal, 100-150 parts of rice bran, 10-15 parts of soybean oil, 15-20 parts of stone powder, 15-20 parts of calcium hydrogen phosphate, 5-10 parts of a premix of vitamins and trace elements, 4-5 parts of salt, 0.1-0.5 part of bacillus subtilis, 0.1-0.5 part of a compound enzyme preparation,1-5 parts of lactic acid and 1-3 parts of amino acids. The compound feed disclosed by the invention is good in application effects.

The invention belongs to the field of technologies for preparing medicines, and discloses an estrus promoting powder medicine and a method for preparing the same. The estrus promoting powder medicine comprises, by weight, 6 g of herba epimedii, 6 g of (alcohol-quenched) actinolite, 4 g of radix angelicae sinensis, 6 g of herba leonuri, 5 g of semen cuscutae and 6 g of herba agrimoniae. The herba epimedii, the (alcohol-quenched) actinolite, the radix angelicae sinensis, the herba leonuri, the semen cuscutae and the herba agrimoniae are mixed with one another to obtain the estrus promoting powder medicine. The estrus promoting powder medicine and the method have the advantages that the herba epimedii, the (alcohol-quenched) actinolite, the radix angelicae sinensis, the herba leonuri, the semen cuscutae and the herba agrimoniae are smashed and sieved and are uniformly mixed with one another to obtain estrus promoting powder, good estrus promoting effects can be realized by the estrus promoting powder, the estrus promoting powder is short in action effect time, reproductive development of parent bodies and young bodies can be effectively maintained, the abortion probability can be lowered, and the farrowing rate can be increased.

The invention discloses an embryo-reduction device, which comprises a puncture needle body and a signal-radiation plate, wherein the puncture needle body is in a hollow structure; the point of the puncture needle body is provided with a motor; one end of the motor is fixed with an output shaft; the tip of the output shaft is provided with rotary vanes; the other end of the motor is fixedly provided with a screw rod which is in screw match with a screw rod pusher; the screw rod pusher is fixed on the inner wall of the puncture needle body through a bracket; the screw rod pusher is provided with an expansion signal receiver; the motor is provided with a switch signal receiver; the signal-radiation plate is provided with a switch signal radiator matched with the switch signal receiver and an expansion signal radiator matched with the expansion signal receiver. The invention is suitable for the embryo pregnant for more than 8 weeks, does not need medicine injection, and has small operation range, short operation time and small residual slough.

The invention relates to the technical field of the raising of water buffalos and particularly relates to a water buffalo feed as well as a preparation and application of a water buffalo feed. A basic ration of the water buffalo feed contains the following raw materials: fermented alfalfa, grassiness, fermented manioc waste, broadleaf paspalum, bean pulp and bran. After being fermented, the alfalfa and the manioc waste in the basic ration are capable of softening fibers in the feed and producing enough alcohol fragrance, so that the content of cyanide is decreased, the palatability of the fed is improved, and the basic nutritional requirements of water buffalos in a gestation period can be met. A feed additive contains the following raw materials: a black bean extract, emulsified calcium, calcium citrate, table salt, yeast chromium, malt juice and a soybean extract. According to the water buffalo feed, the estrus rate of unfertilized female water buffalos can be increased, the pregnancy rate can be increased, the fluency rate can be decreased, meanwhile, the daily food intake can be increased, and the nutritional supply of the female water buffalos in the gestation period can be guaranteed.

Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of a CD200 protein or a nucleic acid encoding a CD200 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune disease, and allergies. Methods and compositions for preventing immune suppression are also disclosed. The methods involve administering an effective amount of an agent that inhibits CD200. Such methods are useful in treating cancer.

The invention provides a protocol leading to improved embryo implantation rates and / or decreased miscarriage rates in which hCG, or a bio-analogue, is administered during the follicular phase.

The invention belongs to the technical field of biomedicine, and discloses cells for targeted treatment of habitual abortion and immune infertility and a preparation method of the cells. The preparation method of the cells for the targeted treatment of the habitual abortion and the immune infertility includes the following steps: aseptically drawing about 20 ml of venous blood of a patient husbandor blood relative or unrelated voluntary healthy individual, and performing heparin anticoagulation; under sterile conditions, adding an equal volume of human lymphocyte separation solution to a centrifuge tube, slowly adding the anticoagulant whole blood to the upper layer of the human lymphocyte separation solution, and performing centrifugation at 4 DEG C and 800-1200 rpm in a slow rise and fall manner; and drawing a separated buffy coat by using a pipette, performing washing by using normal saline, performing resuspension, performing centrifugation at 800-1200 rpm, repeating the operationfor 3 times, removing residual serum, red blood cells and the like, preparing a cell suspension with a density of (2-4)x10<7> / ml, and performing temporary storage at 4 DEG C. The cells improve the conception rate, reduce the miscarriage rate, and make the pregnancy success rate reach 70-80% or more.

The invention discloses a threonine chelate of selenium-threonine and the preparation method comprises the following steps: mixing the selenium dioxide with threonine aqueous solution according to a mole ratio of (0.9-1.1):4 to react at 60-100 DEG C and with a pH value of 4-8 for 0.5-6h under protection of inert gas and obtaining a reaction product; vacuum concentrating or extracting the reaction products with an organic solvent, drying and crushing to obtain the finished product selenium-threonine. The selenium-threonine of the invention can be used as the animal feed additive so that the aim to effectively promote the growth of the animal, strengthen the resistance of the animal and improve the utilization efficiency of animal feed can be realized.

The invention discloses a traditional Chinese medicine composition for preventing and treating miscarriage of goats. The traditional Chinese medicine composition comprises, by weight, 35-55 grams of radix astragali, 20-35 grams of radix angelicae sinensis, 20-35 grams of parched radix paeoniae alba, 25-40 grams of radix codonopsis, 20-45 grams of rhizoma atractylodis macrocephalae, 20-40 grams of radix glycyrrhizae preparata, 20-40 grams of vinegar-processed folium artemisiae argyi, 20-40 grams of semen cuscutae, 30-50 grams of herba taxilli, 20-40 grams of radix dipsaci, 20-40 grams of radix scutellariae and 30-55 grams of colla corii asini. The traditional Chinese medicine composition for preventing and treating miscarriage of the goats has the advantages that effects of reinforcing qi, nourishing blood, strengthening kidneys for fetus soothing, enhancing disease-resistant mechanisms of the ewes and improving the diathesis of the ewes can be realized from an angle of differentiation of traditional Chinese medicine, and accordingly the purposes of nourishing the qi and the blood, stabilizing uteruses and preventing miscarriage can be achieved; a prevention and treatment combined method is implemented, and accordingly the miscarriage rate of the goats can be reduced by 85% at least.

The present invention provides a specific clinical nutritional formula for females after abortion. The nutritional formula comprises the following components in parts by weight: 15-30 parts of proteins, 0.1-1 part of fat, 30-55 parts of carbohydrates, 5-10 parts of dietary fibers, 0.15-0.5 part of macroelement, 0.05-0.1 part of trace element, 0.005-0.03 part of fat-soluble vitamin, 0.05-0.5 part of water-soluble vitamin, 0.01-0.05 part of dietary essence, 0.1-1 part of medicinally and edibly homologous ingredient, 0.5-2.0 parts of natural plant compounds and 0.01-2 parts of new resource food.The present invention also provides a preparation method of the two nutritional formulas. The specific clinical nutritional formula can provide full and sufficient nutritional supports for the femalesafter abortion, enables the females to rapidly restore physical fitness, at the same time can relieve post-abortion anxiety, enhances immunity, benefits qi and nourishes blood, and regulates uterus to avoid re-abortion.

The invention provides a protocol leading to improved embryo implantation rates and / or decreased miscarriage rates in which hCG or LH, or a bio-analogue thereof, is administered during the follicular phase.

The present invention mainly relates to the technical field of breeding and discloses a feed additive used for pregnant ewes in a late period. The feed additive is prepared from the following raw materials: egg shells, walnuts, green papayas, folium ginkgo, camphor tree leaves, flos sophorae immaturus, semen pruni, herb of virgate lespedeza, sea buckthorn seed oil, fructooligosaccharides, compound proteins, compound minerals, compound vitamins and grape wine yeasts. The feed additive is rich in raw materials and balanced in nutrition, protects gastrointestinal functions of the ewes, is easy to digest and absorb, reduces sickness rate of the ewes by 4.7%, promotes the growth and development of fetuses, decreases miscarriage rate by 3.2%, significantly improves the breeding efficiency, and increases economic incomes of farmers by 9.8%. The eggshells, walnuts and green papayas are subjected to primary fermentation with the grape wine yeasts, fragrance components are increased, palatability is improved, the feed additive is balanced in nutrition, promotes digestion and absorption of the ewes, improves feed utilization and disease resistance of the ewes, speeds up the secretion of milk, is conducive to fetal growth, and increases the survival rate of lambs by 3.6%.

The invention discloses application of himalayan teasel root total saponins in preparation of miscarriage prevention medicines. By adopting the himalayan teasel root total saponins, expression of estrogen and progestrone receptors in the uterus and ovary of an animal model can be promoted, vaginal bleeding of the animal model is obviously reduced, the live-birth number is obviously improved, the abortion number is reduced, and the abortion rate is lowered; animal pregnancy is protected from multiple levels and multiple factors, and the miscarriage prevention effect is very obvious.

The invention discloses an application of parasitic loranthus total polysaccharides in preparation of an antiabortifacient. The parasitic loranthus total polysaccharides can promote pregnancy deciduas, and expression of estrogen and progestrone receptor of an ovary of an animal model, and can improve serum E2 and P level; secretion within the gestation period is adjusted; colporrhagia of the animal model is reduced; the abortion frequency is lowered; the abortion rate is lowered; gestation of rats is protected from multiple levels and factors; the miscarriage prevention effect is significant; and the curative effect is more excellent than those of parasitic loranthus total extracts.

The invention discloses a threonine chelate of selenium-threonine and the preparation method comprises the following steps: mixing the selenium dioxide with threonine aqueous solution according to a mole ratio of (0.9-1.1):4 to react at 60-100 DEG C and with a pH value of 4-8 for 0.5-6h under protection of inert gas and obtaining a reaction product; vacuum concentrating or extracting the reaction products with an organic solvent, drying and crushing to obtain the finished product selenium-threonine. The selenium-threonine of the invention can be used as the animal feed additive so that the aim to effectively promote the growth of the animal, strengthen the resistance of the animal and improve the utilization efficiency of animal feed can be realized.

The invention relates to the stock keeping feed additive field, in particular to meat breeding sheep pre-mixing feed. The invention solves the problems existing in the meat breeding sheep feeding that the feed modulation technology is lack, the nutrition is extremely unbalanced, and the feed conversion rate is low, the invention is dispensed of MnSO4H2O, FeSO47H2O, CuSO45H2O, KI, ZnO, Na2SeO35H2O, CoCl26H2O, MgO, NaHCO3, Na2SO4, Vitamin A, Vitamin D, Vitamin E, stone powder, Ca(HPO4)2, methionine, lysine, bone powder, carbamade and wheat of poor quality, and is added according to 3 percent ofconcentrated feed daily grain. The invention refers to the domestic and foreign meat sheep feeding standards, integrates the meat sheep raising characteristics, nutrition requirements and metabolism theory, and performs an optimum composition to the nutrients such as mineral substance, vitamins and amino acids, the adopted raw materials conform to the feed additive using standards issued by the country, to ensure that the nutrition of the daily grain concentrated feed is balanced, to contain adequate protein, vitamins, trace elements and other mineral substances, the feed conversion rate is enhanced, the feed is secure, and the invention can completely satisfy the nutrition requirements of the meat breeding sheep.