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Application of himalayan teasel root total saponins in preparation of miscarriage prevention medicines

A technology of total saponins and medicines, which is applied in the application field of interrupted total saponins in the preparation of tocolytic medicines, and can solve the problems of limitations and side effects, and the inability to safely and effectively prevent spontaneous abortion and the like.

Active Publication Date: 2015-01-21
罗颂平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0027] At present, for the treatment of spontaneous abortion, Western medicine mostly uses expectant therapy, hormone therapy and immunotherapy, but these methods have various limitations and side effects, and cannot prevent and treat spontaneous abortion safely and effectively

Method used

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  • Application of himalayan teasel root total saponins in preparation of miscarriage prevention medicines
  • Application of himalayan teasel root total saponins in preparation of miscarriage prevention medicines
  • Application of himalayan teasel root total saponins in preparation of miscarriage prevention medicines

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0070] 2.1 Preparation of experimental drugs

[0071] 2.1.1 Preparation of Dipsacus total extract and Dipsacus total saponins

[0072] 3.5 kg of Dipsacus were dried, chopped, processed into granules by a pulverizer, and extracted three times by reflux of 6 times 75% ethanol (2 hours, 1.5hr and 1.5hr respectively). After filtration, the three filtrates were combined, concentrated under reduced pressure by a rotary evaporator to remove ethanol, and concentrated to about 1500 mL alcohol-free Dipsacus ethanol extract. Concentration conditions under reduced pressure: the concentration temperature range is 55°C-60°C, the concentration speed is 70 rpm / min, and the vacuum degree is less than 0.1 Mpa.

[0073] Dipsacaceae alcohol extract was applied to HP-20 macroporous resin column (Diaion HP-20, Mitsubishi Chemical Co., Ltd., Japan, 100 mm in diameter, 1 m in height), first eluted with double distilled water until nearly colorless, and then 8L 95% Ethanol was used for elution, and ...

Embodiment 1

[0238] Example 1: Preparation of Dipsacus total saponins

[0239] 3.5kg of Dipsacus were dried, chopped, processed into granules by a pulverizer, and refluxed and extracted with 6 times (weight / volume ratio) 75% ethanol three times (2 hours, 1.5hr and 1.5hr respectively). After filtration, the three filtrates were combined, concentrated under reduced pressure by a rotary evaporator to remove ethanol, and concentrated to about 1500 mL alcohol-free Dipsacus ethanol extract. Concentration conditions under reduced pressure: the concentration temperature range is 55°C-60°C, the concentration speed is 70 rpm (revolutions per minute), and the vacuum degree is less than 0.1 Mpa.

[0240] Dipsacaceae alcohol extract was applied to HP-20 macroporous resin column (Diaion HP-20, Mitsubishi Chemical Co., Ltd., Japan, 100 mm in diameter, 1 m in height), first eluted with double distilled water until nearly colorless, and then 8L 95% Ethanol was used for elution, and 95% ethanol eluate wa...

Embodiment 2

[0242] Embodiment two: the preparation of the total saponins of Radix Dipsaceae

[0243] 3.5kg of Dipsacus were dried, chopped, processed into granules by a pulverizer, and extracted three times by 5 times (weight / volume ratio) 75% ethanol reflux (2 hours, 1.5hr and 1.5hr respectively). After filtration, the three filtrates were combined, concentrated under reduced pressure by a rotary evaporator to remove ethanol, and concentrated to about 1500 mL alcohol-free Dipsacus ethanol extract. Concentration conditions under reduced pressure: the concentration temperature range is 55°C, the concentration speed is 70 rpm (revolutions per minute), and the vacuum degree is less than 0.1 Mpa.

[0244] Dipsacaceae alcohol extract was applied to HP-20 macroporous resin column (Diaion HP-20, Mitsubishi Chemical Co., Ltd., Japan, 100 mm in diameter, 1 m in height), first eluted with double distilled water until nearly colorless, and then 8L 95% Ethanol was used for elution, and 95% ethanol e...

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Abstract

The invention discloses application of himalayan teasel root total saponins in preparation of miscarriage prevention medicines. By adopting the himalayan teasel root total saponins, expression of estrogen and progestrone receptors in the uterus and ovary of an animal model can be promoted, vaginal bleeding of the animal model is obviously reduced, the live-birth number is obviously improved, the abortion number is reduced, and the abortion rate is lowered; animal pregnancy is protected from multiple levels and multiple factors, and the miscarriage prevention effect is very obvious.

Description

technical field [0001] The present invention relates to the use of the effective fraction of Dipsacus, in particular the application of total saponins of Dipsacus in the preparation of anti-fetal drugs. Background technique [0002] Dipsacus, derived from the dried root of Dipsacus asper Wall. Ex Henry, a plant of the Dipsacaceae family, first recorded in "Shen Nong's Herbal Classic", has the functions of nourishing the liver and kidney, strengthening bones and bones, continuing fractures, stopping metrorrhagia, and preventing miscarriage It is widely used in various clinical departments to treat soreness of the waist and knees, rheumatic arthralgia, fall injury, metrorrhagia, fetal leakage, fetal restlessness and other diseases. The chemical composition of Dipsacus mainly contains triterpenoid saponins, iridoids, alkaloids, volatile oils and other components. Modern pharmacological studies have found that it has the functions of antibacterial and anti-inflammatory, immune ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P15/06A61P15/02A61P7/04A61P15/08A61P5/00
CPCA61K36/185A61K2236/33A61K2236/55
Inventor 罗颂平郜洁缪江霞
Owner 罗颂平
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